Gene Information gene info

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GENE：PTPN11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN11
FullNmae protein tyrosine phosphatase non-receptor type 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9644
EnsembleID ENSG00000179295
Uniprot Q06124

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN11 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTPN11 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTPN11 GO:0000077,GO:0001784,GO:0001784,GO:0004721,GO:0004725,GO:0004725,GO:0004725,GO:0004725,GO:0004726,GO:0004726,GO:0004726,GO:0004726,GO:0005158,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005829,GO:0006470,GO:0006470,GO:0006641,GO:0007173,GO:0007229,GO:0007409,GO:0007420,GO:0007507,GO:0008543,GO:0009755,GO:0019221,GO:0019901,GO:0021697,GO:0030159,GO:0030220,GO:0030971,GO:0031295,GO:0032331,GO:0032480,GO:0032528,GO:0032728,GO:0032755,GO:0032760,GO:0032991,GO:0033628,GO:0033629,GO:0035264,GO:0035265,GO:0035335,GO:0035335,GO:0035855,GO:0036302,GO:0038127,GO:0042445,GO:0042593,GO:0043254,GO:0045296,GO:0045778,GO:0045931,GO:0046326,GO:0046628,GO:0046676,GO:0046825,GO:0046887,GO:0048008,GO:0048011,GO:0048013,GO:0048609,GO:0048806,GO:0048839,GO:0048873,GO:0050731,GO:0050839,GO:0050839,GO:0051428,GO:0051463,GO:0060020,GO:0060090,GO:0060125,GO:0060325,GO:0060338,GO:0061582,GO:0070374,GO:0070374,GO:0071364,GO:1990782

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPN11 hsa:5781 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04148 Efferocytosis - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04360 Axon guidance - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa04931 Insulin resistance - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
PTPN11 hsa:5781 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPN11 GAB2 10068651 10358138 10391903 10849428 10871282 10982827 11027663 11287610 11334882 11447289 11572860 11782427 11812650 12135708 12138178 12640133 12707331 15240681 15699106 15713798 16212621 19833085 19909365 21636860 23180781 23331499 26192618 9751747 stimulation,association,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink
PTPN11 PDCD1 10358138 11447289 11572860 12138178 12176909 12707331 12773515 12917349 15240681 15699106 15713798 17371980 19833085 22437870 22513334 22952938 23732914 25355530 26192618 26667266 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN11 PTPN6 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26192618 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN11 KLRG1 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
NECTIN2 PTPN11 12913096 19098271 22285893 26192618 26755705 interaction type N/A ACSN
PTPN11 CD226 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN11 CD247 10358138 10849428 10982827 11447289 11572860 12138178 12640133 12707331 15240681 15699106 15713798 16212621 19833085 19909365 26192618 9751747 interaction type N/A ACSN
PTPN11 IL2 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 CXCL8 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 TNF 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 IFNG 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN11 IL10 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
PTPN11 IL13 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26192618 26667266 26755705 27474009 8976179 8986721 9751747 9765283 interaction type N/A ACSN
CDH1 PTPN11 16424155 16461340 17617594 26192618 interaction type N/A ACSN
PTPN11 IL6 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 IL1B 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
FRS2 PTPN11 11447289 17673906 23331499 25772309 26192618 9632781 interaction type,stimulation N/A ACSN,SignaLink
PTPN11 GRB2 10358138 11447289 11572860 11602579 12138178 12707331 15240681 15699106 15713798 19833085 23180781 26192618 8978300 9751747 interaction type,physical association anti tag coimmunoprecipitation,pull down ACSN,InnateDB
FYN PTPN11 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 26192618 27192565 9738502 interaction type N/A ACSN
FCER1G PTPN11 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 26192618 9625766 9751747 interaction type N/A ACSN
HLA-G PTPN11 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 26192618 9625766 9751747 interaction type N/A ACSN
KIR2DL4 PTPN11 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 26192618 9625766 9751747 interaction type N/A ACSN
HLA-B PTPN11 11513144 11994457 26192618 8976179 8986721 9605119 9751747 interaction type N/A ACSN
KIR3DL1 PTPN11 11513144 11994457 26192618 8976179 8986721 9605119 9751747 interaction type N/A ACSN
HLA-E PTPN11 10358164 11015446 11062502 12731048 15120186 15536084 22464172 26192618 2731048 8478617 9485206 9486650 9655483 interaction type N/A ACSN
KLRD1 PTPN11 10358164 11015446 11062502 12731048 15120186 15536084 22464172 26192618 2731048 8478617 9485206 9486650 9655483 interaction type N/A ACSN
HLA-C PTPN11 11513144 21339333 26192618 9605119 interaction type N/A ACSN
KIR2DL1 PTPN11 11513144 12515815 12917349 16606694 18574028 18835194 23180781 26192618 9751747 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
KIR2DL3 PTPN11 11513144 26192618 8574854 9751747 interaction type N/A ACSN
KIR2DL2 PTPN11 11513144 21339333 26192618 9605119 interaction type N/A ACSN
PTPN11 STAT1 10358138 11447289 11572860 12138178 12270932 12707331 15240681 15699106 15713798 18508557 18832710 18988627 19833085 23180781 23331499 26192618 9751747 interaction type,stimulation,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink,SignaLink
PTPN11 JAK1 12270932 23180781 8790359 physical association anti tag coimmunoprecipitation InnateDB
EGFR PTPN11 12270932 23180781 physical association anti tag coimmunoprecipitation InnateDB
TYK2 PTPN11 23180781 9794795 physical association anti tag coimmunoprecipitation InnateDB
AXL PTPN11 15507525 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 MAP3K5 19287004 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IRF8 PTPN11 16914719 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 CD33 10206955 10887109 17008544 17947393 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
PTPN11 SIGLEC5 19596804 23180781 physical association anti tag coimmunoprecipitation InnateDB
GAB1 PTPN11 11027663 11779868 23180781 23331499 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
BTLA PTPN11 12796776 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 IL22RA1 20671117 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 SIGLEC10 11328818 11733002 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
PTPN11 SIGLEC7 17138568 23180781 physical association pull down InnateDB
PTPN11 KIR2DL1 19828694 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 KIR3DL1 15187115 23180781 physical association anti tag coimmunoprecipitation InnateDB
CSF2RB PTPN11 18322230 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 SELE 11602579 23180781 physical association anti tag coimmunoprecipitation InnateDB
LST1 PTPN11 22589543 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN11 PTPN11 10068651 11323411 12270932 17974954 26467481 dephosphorylation reaction,up-regulates activity,down-regulates,down-regulates activity N/A Signor
JAK2 PTPN11 21071413 23331499 8995399 stimulation N/A SignaLink,SignaLink
PTPN11 JAK2 14522994 18988627 21071413 23331499 7559603 8639815 8912646 8995399 interaction type N/A SignaLink,SignaLink
JAK1 PTPN11 12403768 21071413 23331499 8995399 stimulation N/A SignaLink,SignaLink
PTPN11 JAK3 23331499 8766559 stimulation N/A SignaLink
PTPN11 IGF1R 10082579 11779860 23331499 7642582 stimulation N/A SignaLink
SIRPA PTPN11 11779860 23331499 stimulation N/A SignaLink
PTPN11 STAT5A 10617656 12060651 12237455 18508557 23331499 stimulation N/A SignaLink
PTPN11 STAT3 11594781 18508557 23331499 stimulation N/A SignaLink
PDGFRB PTPN11 11266449 23331499 7691811 stimulation N/A SignaLink
GAB2 PTPN11 15170389 23109003 chemical activation reaction N/A SignaLink
PDCD1 PTPN11 11160222 15240681 15358536 23109003 chemical activation reaction N/A SignaLink
CTLA4 PTPN11 11905831 15790353 16107703 23109003 chemical activation reaction N/A SignaLink
PTPN11 PIK3R1 15790353 16107703 17722974 22315502 23109003 8080844 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BCAR1 PTPN11 20005715 interaction type N/A PSP,SignaLink
CAV1 PTPN11 20005715 interaction type N/A PSP
DAB1 PTPN11 20005715 interaction type N/A PSP
FRS2 PTPN11 20005715 interaction type N/A PSP
FRS3 PTPN11 20005715 interaction type N/A PSP
GAB1 PTPN11 20005715 interaction type N/A PSP,SignaLink
GRB2 PTPN11 20005715 interaction type N/A PSP
GRB7 PTPN11 20005715 interaction type N/A PSP,SignaLink
IRS1 PTPN11 20005715 interaction type N/A PSP
IRS2 PTPN11 20005715 interaction type N/A PSP
IRS4 PTPN11 20005715 interaction type N/A PSP
MPZL1 PTPN11 20005715 interaction type N/A PSP,SignaLink
NEDD9 PTPN11 20005715 interaction type N/A PSP
PAG1 PTPN11 20005715 interaction type N/A PSP
PIK3R1 PTPN11 20005715 interaction type N/A PSP
PXN PTPN11 20005715 interaction type N/A PSP,SignaLink
SHC1 PTPN11 20005715 interaction type N/A PSP
SIT1 PTPN11 20005715 interaction type N/A PSP
SOCS3 PTPN11 20005715 interaction type N/A PSP
SPRY2 PTPN11 20005715 interaction type N/A PSP,SignaLink
CAV1 PTPN11 12176037 18988627 20005715 21071413 N/A N/A SignaLink
NEDD9 PTPN11 18988627 20005715 8879209 N/A N/A SignaLink
GRB2 PTPN11 10212213 20005715 21071413 8702859 N/A N/A SignaLink
DAB1 PTPN11 15062102 18988627 20005715 20005715 N/A N/A SignaLink
FRS2 PTPN11 20005715 20005715 N/A N/A SignaLink
IRS4 PTPN11 12774026 18988627 20005715 20005715 N/A N/A SignaLink
PAG1 PTPN11 10790433 18988627 20005715 20005715 N/A N/A SignaLink
SOCS3 PTPN11 12403768 12403768 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 PTPN11 20005715 20005715 21071413 8505282 9756938 N/A N/A SignaLink
IRS2 PTPN11 18988627 20005715 20005715 8910607 N/A N/A SignaLink
PIK3R1 PTPN11 20005715 20005715 N/A N/A SignaLink
SHC1 PTPN11 10650943 18988627 20005715 20005715 N/A N/A SignaLink
FRS3 PTPN11 11432792 18988627 20005715 20005715 N/A N/A SignaLink
SIT1 PTPN11 10209036 11433379 11491537 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 PTPN11 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PTPN11 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PTPN11 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC864 PTPN11 23420868 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000009C45F PTPN11 20700123 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000009C45F PTPN11 20700123 25416803 26918448 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001CC864 PTPN11 23420868 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002C0FCB PTPN11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 PTPN11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PTPN11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB PTPN11 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000012930C PTPN11 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E PTPN11 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 PTPN11 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 PTPN11 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC PTPN11 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCH PTPN11 22135298 phosphorylation N/A PhosphoSite
FYN PTPN11 22135298 phosphorylation N/A PhosphoSite
PRKCA PTPN11 22135298 phosphorylation N/A PhosphoSite
PRKCB PTPN11 22135298 phosphorylation N/A PhosphoSite
ALK PTPN11 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GOLGA2 PTPN11 25348397 N/A physical interaction ComPPI
PIK3R2 PTPN11 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
LGALS3 PTPN11 25348397 N/A physical interaction ComPPI
CDC73 PTPN11 25348397 N/A physical interaction ComPPI
FRS3 PTPN11 11432792 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
SOCS3 PTPN11 12403768 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ROR2 PTPN11 25348397 N/A physical interaction ComPPI
SPRY2 PTPN11 14525934 15031289 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GPX7 PTPN11 25348397 N/A physical interaction ComPPI
ANXA1 PTPN11 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
STAT1 PTPN11 12270932 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RPIA PTPN11 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GTF2A2 PTPN11 25348397 N/A physical interaction ComPPI
TRIM32 PTPN11 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MED21 PTPN11 25348397 N/A physical interaction ComPPI
H2BC4 PTPN11 25348397 N/A physical interaction ComPPI
PTPN6 PTPN11 14525934 25348397 8541543 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SERPINF1 PTPN11 25348397 N/A physical interaction ComPPI
CRK PTPN11 25348397 N/A physical interaction ComPPI
SLN PTPN11 25348397 N/A physical interaction ComPPI
SLC38A1 PTPN11 25348397 N/A physical interaction ComPPI
BEX1 PTPN11 25348397 N/A physical interaction ComPPI
CHRAC1 PTPN11 25348397 N/A physical interaction ComPPI
ERBB2 PTPN11 14525934 16273093 16729043 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TXNIP PTPN11 25348397 N/A physical interaction ComPPI
CBL PTPN11 11157475 14525934 17330819 18519587 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PRLR PTPN11 10991949 14522994 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
IL6ST PTPN11 10946280 12403768 14525934 25348397 9195977 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTK2B PTPN11 10880513 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOCS1 PTPN11 25348397 N/A physical interaction ComPPI
CBLB PTPN11 25348397 N/A physical interaction ComPPI
PAG1 PTPN11 10790433 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PECAM1 PTPN11 10350061 10704309 10801826 24234451 25348397 27898060 9054388 9312087 9774457 association lambda phage display,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
ERBB4 PTPN11 16729043 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
KIT PTPN11 14525934 24234451 24728074 25348397 7523381 9528781 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3R1 PTPN11 14525934 25348397 9918857 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 IFNAR1 14525934 25348397 9029147 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 PDGFRB 12614164 12681492 14525934 23397142 24234451 25348397 7530043 7688466 7691811 8041791 8119896 8183548 8538796 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,affinity technology,enzymatic study,in vitro,in vivo,proximity ligation assay,surface plasmon resonance array ComPPI,HPRD,IntAct
PTPN11 PDGFRA 14525934 25348397 8943348 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 EPHA2 10655584 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 PRKCA 11781100 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 PRKCB 11781100 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 TNFRSF1A 11786908 14525934 24234451 25348397 association experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
PTPN11 TIE1 10949653 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 SHC1 10650943 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 IRS2 14525934 25348397 8910607 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 GHR 10976913 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 LEPR 11018044 11342028 14525934 24234451 25348397 27898060 9600917 association anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
PTPN11 CAV1 12176037 14525934 24234451 25348397 colocalization,physical association coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN11 CDH5 10681592 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PTPN11 STAT5A 10617656 12060651 12237455 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 CRKL 14525934 23397142 24234451 25348397 9344843 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PTPN11 PXN 14665621 23397142 24234451 25348397 association,physical association anti bait coimmunoprecipitation,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
PTPN11 HNRNPU 14525934 25348397 8943344 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 LAIR1 25348397 N/A physical interaction,in vitro ComPPI
PTPN11 DAB1 14525934 15062102 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 SLAMF1 11313386 11806999 14525934 24234451 25348397 association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PTPN11 IRS4 12774026 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 STAT5B 10617656 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN11 MPZL1 10681522 11751924 14525934 24234451 25348397 9792637 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 SIGLEC7 10499918 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 ACTN4 11382784 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PTPN11 SIT1 10209036 11433379 11491537 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,competition binding,in vivo ComPPI,HPRD,IntAct
PTPN11 PILRA 10660620 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 PRKCH 11781100 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 GAB2 10068651 11287610 11812650 14525934 15170389 16253990 19172738 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 SLAMF6 11489943 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 SIGLEC11 11986327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 FRS2 11447289 14525934 24234451 25348397 29997244 9632781 association,physical association bioluminescence resonance energy transfer,coimmunoprecipitation,experimental interaction detection,far western blotting,physical interaction,in vitro,in vivo,luminescence based mammalian interactome mapping ComPPI,HPRD,IntAct
PTPN11 BTLA 12796776 14525934 14652006 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PTPN11 GAB3 11739737 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 INPP5D 14525934 25348397 9110989 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 TREML1 14525934 15128762 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PTPN11 NEDD9 14525934 25348397 8879209 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 LILRB4 25348397 N/A in vitro ComPPI
PTPN11 SIGLEC12 11328818 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PTPN11 GRB2 12531430 12577067 14525934 19380743 21706016 24234451 25348397 7523381 8041791 8702859 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PTPN11 CEACAM1 12108545 14525934 25348397 9867848 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN11 BDKRB2 12177051 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PTPN11 CAT 14525934 15556604 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct,OmniPath
PTPN11 SIRPA 14525934 25348397 8943344 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN11 STAT3 11594781 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 ARHGAP1 14525934 15169898 15588985 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 MS4A2 14525934 25348397 9379041 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 KIR2DL5A 14525934 15187115 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 RET 12959980 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 FLT1 14525934 23397142 24234451 25348397 9600074 physical association two hybrid,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
PTPN11 IFNGR1 10022928 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 CXCR4 11157475 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 KDR 14525934 25348397 9405464 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 FLT4 14525934 15102829 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 SRC 14525934 14687660 20308328 24234451 25348397 dephosphorylation reaction experimental interaction detection,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
PTPN11 AXL 14525934 15507525 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 GRIN2B 10381539 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PTPN11 MPL 14525934 25348397 8541543 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 SOS1 14525934 25348397 9344843 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 NTRK1 14525934 25348397 9282923 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN11 NTRK2 10386953 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 CHUK 11136824 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 PIK3CG 10386953 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 MAPK3 14525934 23397142 24234451 25348397 8197172 physical association experimental interaction detection,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
PTPN11 PILRB 25348397 N/A in vitro,in vivo ComPPI
PTPN11 MAP3K4 14525934 15601262 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 CTLA4 14525934 25348397 8638161 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 CCKBR 14525934 16963136 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 SELE 11602579 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PTPN11 EGFR 11223155 14525934 14560030 16273093 16729043 24234451 25348397 7673163 physical association experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 EPOR 14525934 25348397 8639815 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 FYN 10212213 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN11 CSF3R 14525934 25348397 9824671 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 CSF2RB 14525934 24234451 25348397 9162089 9254654 9973406 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 DDR1 14525934 16337946 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,IntAct
PTPN11 IRS1 14525934 24234451 25348397 7513703 7935386 8505282 9756938 association experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
PTPN11 INSR 14525934 24234451 25348397 7493946 8135823 9593725 association,physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 IL4R 11714803 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN11 JAK1 11036942 12403768 14525934 25348397 8995399 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 JAK2 14525934 25348397 7559603 8912646 8995399 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 BCR 12115002 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN11 LIFR 10800945 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 LCK 10617656 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN11 CD33 10206955 14525934 17947393 24234451 25348397 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
PTPN11 KLRC1 14525934 25348397 9485206 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN11 MET 14525934 18579758 24234451 24728074 25348397 8662733 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,in vivo ComPPI,HPRD,IntAct
PTPN11 SYNCRIP 25348397 N/A physical interaction ComPPI
PTPN11 ROS1 25348397 N/A physical interaction ComPPI
PTPN11 PLCG2 25348397 N/A physical interaction ComPPI
PTPN11 PTK2 25348397 N/A physical interaction ComPPI
PTPN11 BCAR1 25348397 N/A physical interaction ComPPI
PTPN11 MPIG6B 11544253 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PTPN11 CTNNB1 25348397 N/A physical interaction ComPPI
PTPN11 CD84 25348397 N/A physical interaction ComPPI
PTPN11 LY9 25348397 N/A physical interaction ComPPI
PTPN11 FCRL3 25348397 N/A physical interaction ComPPI
PTPN11 CEACAM5 25348397 N/A physical interaction ComPPI
PTPN11 FCGR2B 10382761 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PTPN11 ELAVL1 25348397 N/A physical interaction ComPPI
PTPN11 ERBB3 25348397 N/A physical interaction ComPPI
PTPN11 PAF1 25348397 N/A physical interaction ComPPI
PTPN11 CTR9 25348397 N/A physical interaction ComPPI
PTPN11 RTF1 25348397 N/A physical interaction ComPPI
PTPN11 WDR61 25348397 N/A physical interaction ComPPI
PTPN11 LRRK1 25348397 N/A physical interaction ComPPI
PTPN11 MAP3K5 25348397 N/A physical interaction ComPPI
PTPN11 GSK3B 25348397 N/A physical interaction ComPPI
PTPN11 PPIF 25348397 N/A physical interaction ComPPI
PTPN11 FASN 25348397 N/A physical interaction ComPPI
PTPN11 COP1 25348397 N/A physical interaction ComPPI
PTPN11 CD274 25348397 N/A physical interaction ComPPI
PTPN11 VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PTPN11 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN11 MTPN 25348397 N/A physical interaction ComPPI
PTPN11 EFHD2 25348397 N/A physical interaction ComPPI
PTPN11 MAPK14 25348397 N/A physical interaction ComPPI
PTPN11 OXCT1 25348397 N/A physical interaction ComPPI
PTPN11 OVCA2 25348397 N/A physical interaction ComPPI
PTPN11 FCGR2A 25348397 N/A physical interaction ComPPI
PTPN11 FSD1 25348397 N/A physical interaction ComPPI
PTPN11 LGALS9 25348397 N/A physical interaction ComPPI
PTPN11 TCEAL1 25348397 N/A physical interaction ComPPI
PTPN11 CYP1A1 25348397 N/A physical interaction ComPPI
PTPN11 MAP2K1 25348397 N/A physical interaction ComPPI
PTPN11 STAMBP 25348397 N/A physical interaction ComPPI
PTPN11 LNX1 25348397 N/A physical interaction ComPPI
PTPN11 H2BC11 25348397 N/A physical interaction ComPPI
PTPN11 DNM2 25348397 N/A physical interaction ComPPI
PTPN11 GAREM2 25348397 N/A physical interaction ComPPI
PTPN11 PRPF19 25348397 N/A physical interaction ComPPI
PTPN11 FGFR2 25348397 N/A physical interaction ComPPI
PTPN11 FGFR4 25348397 N/A physical interaction ComPPI
PTPN11 TEK 10521483 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PTPN11 DUSP13 25348397 N/A physical interaction ComPPI
PTPN11 DUSP13 25348397 N/A physical interaction ComPPI
PTPN11 NXT2 25348397 N/A physical interaction ComPPI
PTPN11 GTF2E2 25348397 N/A physical interaction ComPPI
PTPN11 THEMIS 24234451 25348397 25535246 association pull down,physical interaction ComPPI,IntAct
PTPN11 PDCD1 15240681 24234451 25348397 28046066 colocalization,association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
PTPN11 FGB 25348397 N/A physical interaction ComPPI
PTPN11 LUM 25348397 N/A physical interaction ComPPI
PTPN11 TMEM220 25348397 N/A physical interaction ComPPI
PTPN11 NOSIP 25348397 N/A physical interaction ComPPI
PTPN11 AATK 25348397 N/A physical interaction ComPPI
PTPN11 PTK7 25348397 N/A physical interaction ComPPI
PTPN11 EPHA1 25348397 N/A physical interaction ComPPI
PTPN11 TAMALIN 25348397 N/A physical interaction ComPPI
PTPN11 SIGLEC9 25348397 N/A physical interaction ComPPI
PTPN11 TRIM25 25348397 N/A physical interaction ComPPI
PTPN11 BEX2 25348397 N/A physical interaction ComPPI
PTPN11 BLZF1 25348397 N/A physical interaction ComPPI
PTPN11 CTDSP1 25348397 N/A physical interaction ComPPI
PTPN11 DMRTC1 25348397 N/A physical interaction ComPPI
PTPN11 NSUN5 25348397 N/A physical interaction ComPPI
PTPN11 ORMDL3 25348397 N/A physical interaction ComPPI
PTPN11 PLEKHA4 25348397 N/A physical interaction ComPPI
PTPN11 PNCK 25348397 N/A physical interaction ComPPI
PTPN11 POU2AF1 25348397 N/A physical interaction ComPPI
PTPN11 RANGRF 25348397 N/A physical interaction ComPPI
PTPN11 SERF2 25348397 N/A physical interaction ComPPI
PTPN11 SRSF10 25348397 N/A physical interaction ComPPI
PTPN11 TLK1 25348397 N/A physical interaction ComPPI
PTPN11 TRMT2B 25348397 N/A physical interaction ComPPI
PTPN11 HDAC6 25348397 N/A physical interaction ComPPI
PTPN11 PLCG1 14525934 15563458 24234451 25348397 27898060 9020117 physical association experimental interaction detection,pull down ComPPI,HPRD,IntAct,OmniPath
PTPN11 SLC4A1 12070037 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
PTPN11 FLT3 16684964 24234451 25348397 27898060 association coimmunoprecipitation,competition binding ComPPI,IntAct,OmniPath
PTPN11 KIR2DL3 24234451 25348397 8648092 association pull down,surface plasmon resonance ComPPI,IntAct
PTPN11 KIR2DL1 24234451 25348397 9751747 physical association two hybrid,lex-a dimerization assay ComPPI,IntAct
PTPN11 ITGB3 12791772 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
PTPN11 DOK1 15546884 24234451 25348397 27898060 association coimmunoprecipitation ComPPI,IntAct,OmniPath
PTPN11 HOXA10 25348397 N/A genetic ComPPI
PTPN11 SGCG 23414517 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
PTPN11 NEB 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PTPN11 AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PTPN11 CD244 24234451 24642916 25348397 association pull down,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PTPN11 CD300A 11489943 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PTPN11 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
GAB1 PTPN11 10068651 10871282 11134009 11323411 11453982 11940581 12855672 14525934 14665621 14701753 15574420 20308328 24234451 24728074 25348397 9658397 dephosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,far western blotting,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,phosphatase assay,two hybrid ComPPI,HPRD,IntAct
MVP PTPN11 14525934 15133037 15588985 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IGF1R PTPN11 14525934 24234451 25348397 7642582 8895367 association,physical association beta galactosidase complementation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SIGLEC5 PTPN11 25348397 N/A physical interaction ComPPI
LEO1 PTPN11 25348397 N/A physical interaction ComPPI
SNRNP27 PTPN11 25348397 N/A physical interaction ComPPI
PTPN11 ITSN1 24216759 27898060 N/A N/A OmniPath
SRC PTPN11 11684012 12531430 12721296 14687660 20308328 27898060 N/A N/A OmniPath
PTPN11 SRC 14687660 17974954 18482983 20308328 27898060 stimulant N/A OmniPath
PRKACA PTPN11 25802336 27898060 N/A N/A OmniPath
PRKCA PTPN11 11781100 27898060 stimulant N/A OmniPath
PTPN1 PTPN11 21123182 27898060 N/A N/A OmniPath
PRKCB PTPN11 11781100 27898060 N/A N/A OmniPath
FYN PTPN11 10212213 11157475 11684012 12531430 12721296 15710330 17483340 18320059 20855525 27898060 8041791 stimulant N/A OmniPath
EGFR PTPN11 11223155 12270932 12582165 14560030 16273093 16729043 27898060 7673163 8197172 9756944 stimulant N/A OmniPath
PTPN11 EGFR 11223155 12270932 12582165 14560030 16273093 16729043 27898060 7673163 8197172 9756944 inhibition N/A OmniPath
PDGFRB PTPN11 11266449 11684012 12614164 12681492 16094384 17287340 18083107 19534553 19690332 23397142 27898060 7530043 7688466 7691811 8041791 8119896 8183548 8226787 8538796 8622870 stimulant N/A OmniPath
PTPN11 PDGFRB 11266449 12614164 12681492 23397142 27898060 7530043 7545675 7688466 7691811 8041791 8119896 8183548 8538796 inhibition N/A OmniPath
PTPN11 HRAS 26617336 27898060 stimulant N/A OmniPath
PTPN11 JAK3 27898060 8766559 stimulant N/A OmniPath
PTPN11 KDR 19706677 27898060 9405464 inhibition N/A OmniPath
PTPN11 IGF1R 10082579 11779860 27898060 7642582 8895367 stimulant N/A OmniPath
PTPN11 STAT5A 10617656 12060651 12237455 18508557 27898060 inhibition,stimulant N/A OmniPath
PTPN11 IRS1 10660596 11781100 22974441 27898060 7513703 7515062 7935386 8505282 9756938 inhibition N/A OmniPath
PTPN11 MAP3K5 19287004 27898060 stimulant N/A OmniPath
MAP3K5 PTPN11 19287004 27898060 N/A N/A OmniPath
PTPN11 PTK2 10082579 10655584 16920701 21726809 27898060 7589239 8986614 inhibition N/A OmniPath
STAT1 PTPN11 1227093 12270932 18508557 18832710 27898060 N/A N/A OmniPath
PTPN11 STAT1 1227093 12270932 18508557 18832710 27898060 inhibition,stimulant N/A OmniPath
GRB2 PTPN11 10080542 10212213 10747947 11602579 12531430 12577067 19380743 21706016 27898060 7523381 7534299 8041791 8702859 8978300 8995399 9361008 9362449 9632781 9824671 N/A N/A OmniPath
PTPN11 GRB2 10080542 10212213 10747947 11602579 12531430 12577067 19380743 21706016 27898060 7522233 7523381 7534299 8041791 8702859 8978300 8995399 9361008 9362449 9632781 9824671 stimulant N/A OmniPath
PTPN11 GAB1 10068651 10788507 10871282 11027663 11134009 11323411 11453982 11779868 11940581 12582165 12808090 12855672 14701753 14982882 15273746 15574420 20308328 24728074 27898060 8596638 9658397 9804835 inhibition N/A OmniPath
GAB1 PTPN11 10068651 10788507 10871282 11027663 11134009 11323411 11453982 11779868 11940581 12808090 12855672 14701753 14982882 15273746 15574420 20308328 24728074 27898060 8596638 9658397 9804835 stimulant N/A OmniPath
JAK1 PTPN11 11036942 12270932 12403768 27898060 8790359 8995399 stimulant N/A OmniPath
PTPN11 JAK1 11036942 12270932 12403768 27898060 8790359 8995399 inhibition N/A OmniPath
PTPN11 PIK3CA 27898060 7522233 stimulant N/A OmniPath
IRF8 PTPN11 16914719 27898060 N/A N/A OmniPath
PTPN11 TYK2 27898060 9794795 N/A N/A OmniPath
ABL1 PTPN11 20841568 27898060 8195176 N/A N/A OmniPath
PTPN11 PXN 10082579 10655584 14665621 23397142 27898060 8986614 inhibition,stimulant N/A OmniPath
PTPN11 TERT 19737086 27898060 stimulant N/A OmniPath
PTPN11 MAP3K4 15601262 27898060 inhibition N/A OmniPath
PTPN11 HOXA10 19022774 27898060 stimulant N/A OmniPath
PTPN11 STAT3 1159478 11594781 18508557 27898060 stimulant N/A OmniPath
JAK2 PTPN11 14522994 27898060 7559603 8639815 8912646 8995399 stimulant N/A OmniPath
PTPN11 JAK2 14522994 27898060 7559603 8639815 8912646 8995399 inhibition N/A OmniPath
PTPN11 STAT5B 10617656 27898060 inhibition N/A OmniPath
SELE PTPN11 11602579 27898060 N/A N/A OmniPath
PTPN11 SELE 11602579 27898060 N/A N/A OmniPath
SIRPA PTPN11 11779860 11970986 15699129 18450421 27898060 8943344 stimulant N/A OmniPath
PTPN11 SIRPA 11970986 15699129 18450421 27898060 8910355 8943344 inhibition N/A OmniPath
PTPN11 FLT1 23397142 27898060 9600074 N/A N/A OmniPath
CSF2RB PTPN11 18322230 27898060 9162089 9254654 9973406 N/A N/A OmniPath
PTPN11 CSF2RB 18322230 27898060 9162089 9254654 9973406 inhibition,stimulant N/A OmniPath
PTPN11 SPRY1 15031289 16481357 27898060 inhibition N/A OmniPath
SIGLEC5 PTPN11 19596804 27898060 N/A N/A OmniPath
SIGLEC10 PTPN11 11328818 11733002 27898060 N/A N/A OmniPath
CD33 PTPN11 10206955 10887109 17008544 17947393 27898060 N/A N/A OmniPath
PTPN11 FRS2 10650943 11360177 11447289 22974441 27898060 9632781 stimulant N/A OmniPath
FRS2 PTPN11 10650943 11360177 11447289 22974441 27898060 9632781 stimulant N/A OmniPath
PTPN11 SPRY2 15031289 27898060 N/A N/A OmniPath
PTPN11 PAG1 10790433 14967142 27898060 inhibition N/A OmniPath
BTLA PTPN11 12796776 14652006 27898060 N/A N/A OmniPath
SIGLEC7 PTPN11 10499918 17138568 27898060 N/A N/A OmniPath
PTPN11 PTK2B 10880513 27898060 inhibition N/A OmniPath
PTPN11 GAB2 10068651 10391903 10871282 11027663 11287610 11334882 11782427 11812650 12135708 14982882 15170389 15356145 19909739 21636860 27898060 inhibition,stimulant N/A OmniPath
GAB2 PTPN11 10068651 10391903 10871282 11027663 11287610 11334882 11782427 11812650 12135708 14982882 15170389 15356145 19909739 21636860 27898060 stimulant N/A OmniPath
IL22RA1 PTPN11 20671117 27898060 N/A N/A OmniPath
AXL PTPN11 15507525 27898060 N/A N/A OmniPath
PTPN11 CTNNA1 16767162 27898060 inhibition N/A OmniPath
PTPN11 ARHGAP5 15169898 27898060 N/A N/A OmniPath
PRKCH PTPN11 11781100 27898060 N/A N/A OmniPath
PTPN11 MPZL1 10681522 11751924 15588985 27898060 9792637 inhibition N/A OmniPath

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