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GENE：RAF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAF1
FullNmae Raf-1 proto-oncogene, serine/threonine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9829
EnsembleID ENSG00000132155
Uniprot P04049

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAF1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAF1 apoptosis 40227502 Overexpression of RAF1 increased cell viability and decreased apoptosis in PC9 and PC9/AR cells, while knockdown of RAF1 had the opposite effects. retulator signature
RAF1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RAF1 GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005741,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006468,GO:0006915,GO:0007165,GO:0007190,GO:0008285,GO:0008286,GO:0008625,GO:0019899,GO:0030154,GO:0030878,GO:0031143,GO:0031333,GO:0033138,GO:0035019,GO:0035023,GO:0035773,GO:0035994,GO:0042060,GO:0042802,GO:0042981,GO:0043066,GO:0043154,GO:0043410,GO:0044342,GO:0045104,GO:0045595,GO:0045944,GO:0046872,GO:0048009,GO:0048011,GO:0048538,GO:0060324,GO:0060333,GO:0071550,GO:0106310,GO:1902042,GO:2000145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RAF1 hsa:5894 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
RAF1 hsa:5894 path:hsa01522 Endocrine resistance - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04210 Apoptosis - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04218 Cellular senescence - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04360 Axon guidance - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04510 Focal adhesion - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04540 Gap junction - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04720 Long-term potentiation - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04730 Long-term depression - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04916 Melanogenesis - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04929 GnRH secretion - Homo sapiens (human)
RAF1 hsa:5894 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05010 Alzheimer disease - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05034 Alcoholism - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05132 Salmonella infection - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05152 Tuberculosis - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05160 Hepatitis C - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05161 Hepatitis B - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05164 Influenza A - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05200 Pathways in cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05210 Colorectal cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05213 Endometrial cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05214 Glioma - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05215 Prostate cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05218 Melanoma - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05219 Bladder cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05224 Breast cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05226 Gastric cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
RAF1 hsa:5894 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RAF1 YWHAB 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 26192618 7510700 8551221 9069260 9763606 9846483 interaction type N/A ACSN
RAF1 HRAS 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 26192618 7510700 8551221 9069260 9763606 9846483 interaction type N/A ACSN
GRB2 RAF1 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26192618 26552706 7510700 8551221 8929532 9069260 9510155 interaction type N/A ACSN
RAF1 RASGRP1 10567412 10807788 11532940 12419216 12566895 12782630 14764585 15184873 15516985 15567848 16227978 16488589 17496910 19289794 19565474 19615955 21102635 24027568 26192618 9069260 interaction type N/A ACSN
PAK3 RAF1 10461188 10559936 10613909 10712905 11340065 11413130 11950587 26192618 9069260 9823899 interaction type N/A ACSN
RAF1 BAD 11532940 12107820 12566895 14764585 15516985 15849194 19289794 19565474 23180781 24027568 26192618 8929532 9069260 interaction type,phosphorylation reaction protein kinase assay ACSN,InnateDB
BCL2 RAF1 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 15849194 17446862 19289794 19565474 22039431 23064052 23180781 23377657 23430059 23850759 24027568 26192618 8929532 9069260 9872359 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
FOS RAF1 11274345 12738796 15067049 16393692 16394015 18039929 19667062 21385848 22634314 23430059 26192618 9064320 interaction type N/A ACSN
JUN RAF1 11274345 12738796 17439715 18039929 26192618 26587781 8545107 interaction type N/A ACSN
ATF2 RAF1 11274345 12738796 18039929 20506250 26192618 interaction type N/A ACSN
RAF1 XIAP 16964381 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,gst pull down,protein kinase assay InnateDB
SHOC2 RAF1 10783161 23180781 physical association anti tag coimmunoprecipitation InnateDB
HRAS RAF1 10545207 10783161 10882715 10922060 11733498 12379659 12391160 12620389 14654780 14724584 15031288 15688026 16041367 16301319 18988627 21071413 23180781 23331499 7730360 8035810 8332187 8332195 8530446 8911690 9020159 9099670 9150145 9154803 9261098 stimulation,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB,SignaLink,SignaLink
RAF1 SHOC2 10783161 16301319 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 BRAF 16803888 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 PPP1CC 12374792 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 PHB 10523633 16041367 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
RAF1 YWHAQ 14688280 16041367 23180781 physical association anti tag coimmunoprecipitation,surface plasmon resonance InnateDB
RAF1 RB1 10523633 15485920 23180781 physical association anti tag coimmunoprecipitation,gst pull down,in-gel kinase assay InnateDB
RAF1 RAF1 15925322 23180781 phosphorylation reaction in-gel kinase assay InnateDB
RAF1 CASP9 15674327 23180781 cleavage reaction protease assay InnateDB
RAF1 KSR2 12975377 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 SPRY4 12717443 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down InnateDB
RAF1 SPRY2 12717443 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 CAMK2A 12954639 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
RAF1 TSC22D3 12391160 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 AKT1 12087097 23180781 physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
RAF1 PAK1 11733498 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
RAF1 MAP3K5 11427728 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 PRKCE 11350735 23180781 physical association anti tag coimmunoprecipitation InnateDB
ARRB2 RAF1 11226259 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 AGTR1 11226259 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 PEBP1 11585904 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 KRAS 10783161 23180781 physical association two hybrid InnateDB
RAF1 RRAS2 10783161 23180781 physical association two hybrid InnateDB
MAPK1 RAF1 11409918 15664191 15849194 18988627 23180781 23331499 9922370 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay,protein kinase assay InnateDB,SignaLink,SignaLink
RAF1 YWHAG 15664191 23180781 physical association gst pull down InnateDB
RAF1 PIN1 15664191 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
GRB10 RAF1 10585452 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
RAF1 RIPK2 10559258 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2RB RAF1 1639773 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 MAP3K1 10969079 23180781 physical association anti tag coimmunoprecipitation InnateDB
NRAS RAF1 10882715 18988627 21071413 23331499 9488663 9525741 stimulation N/A SignaLink,SignaLink
MAPK3 RAF1 18988627 23331499 9446616 9922370 stimulation N/A SignaLink,SignaLink
RAF1 MAP2K1 10757792 11242034 11604401 15485920 16093354 18988627 21071413 23331499 7731720 8157000 8394352 8621729 stimulation N/A SignaLink,SignaLink
PAK1 RAF1 11948406 23331499 stimulation N/A SignaLink,SignaLink
KRAS RAF1 10882715 16293107 21071413 23331499 stimulation N/A SignaLink,SignaLink
RAF1 MAP2K2 16293107 18988627 23331499 8157000 8393135 9671314 9808624 stimulation N/A SignaLink,SignaLink
PRKACA RAF1 10576742 11971957 11997508 23331499 9091312 9710607 9922370 stimulation N/A SignaLink
PRKCA RAF1 23331499 8321321 9922370 stimulation N/A SignaLink
PEBP1 RAF1 10490027 10757792 17097642 23331499 stimulation N/A SignaLink
PAK2 RAF1 10712905 16837009 23331499 stimulation N/A SignaLink
KSR1 RAF1 11478855 15520859 23331499 stimulation N/A SignaLink
KSR2 RAF1 12975377 23331499 stimulation N/A SignaLink
CNKSR2 RAF1 14597674 23331499 stimulation N/A SignaLink
WDR83 RAF1 15118098 23331499 stimulation N/A SignaLink
PPP2R2A RAF1 15664191 23331499 stimulation N/A SignaLink
CNKSR1 RAF1 15845549 23331499 stimulation N/A SignaLink
LTK RAF1 23331499 8084603 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ARRB2 RAF1 20005715 interaction type N/A PSP
BIRC2 RAF1 20005715 interaction type N/A PSP,SignaLink
CNKSR1 RAF1 20005715 interaction type N/A PSP,SignaLink
COPS3 RAF1 20005715 interaction type N/A PSP
GNG4 RAF1 20005715 interaction type N/A PSP
GRB10 RAF1 10585452 18988627 20005715 21071413 9553107 interaction type N/A PSP,SignaLink
KRT18 RAF1 20005715 interaction type N/A PSP
KRT8 RAF1 20005715 interaction type N/A PSP
MAPK8IP3 RAF1 20005715 interaction type N/A PSP
RSU1 RAF1 20005715 interaction type N/A PSP
SPRY2 RAF1 20005715 interaction type N/A PSP,SignaLink
SPRY4 RAF1 12717443 18988627 20005715 interaction type N/A PSP,SignaLink
YWHAB RAF1 20005715 interaction type N/A PSP
YWHAE RAF1 20005715 interaction type N/A PSP
YWHAG RAF1 20005715 interaction type N/A PSP
YWHAH RAF1 10620507 20005715 21071413 8702721 interaction type N/A PSP,SignaLink
YWHAQ RAF1 20005715 interaction type N/A PSP
YWHAZ RAF1 20005715 interaction type N/A PSP
ARRB2 RAF1 20005715 N/A N/A SignaLink
MAPK8IP3 RAF1 10523642 11044439 18988627 20005715 20005715 N/A N/A SignaLink
YWHAB RAF1 10620507 10848612 12620389 18988627 20005715 20005715 21071413 7644510 7644510 8702721 8702721 N/A N/A SignaLink
YWHAQ RAF1 10620507 20005715 20005715 21071413 N/A N/A SignaLink
YWHAZ RAF1 10620507 12360521 18988627 20005715 20005715 21071413 7628630 7628630 7628630 7939632 9153224 9261098 N/A N/A SignaLink
GNG4 RAF1 18988627 20005715 20005715 21071413 7782277 7782277 N/A N/A SignaLink
KRT18 RAF1 15314064 18988627 20005715 20005715 N/A N/A SignaLink
KRT8 RAF1 15314064 18988627 20005715 20005715 N/A N/A SignaLink
RSU1 RAF1 18988627 20005715 20005715 8816460 N/A N/A SignaLink
YWHAE RAF1 15459208 18988627 20005715 20005715 21071413 7644510 7644510 8702721 8702721 N/A N/A SignaLink
YWHAG RAF1 10433554 10620507 18988627 20005715 20005715 21071413 8702721 N/A N/A SignaLink
COPS3 RAF1 12620389 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR RAF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RAF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RAF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000040EE1D RAF1 21350001 23760062 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007D64A RAF1 21350001 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000021D7C8 RAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED RAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000072E4C RAF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 RAF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000032D69B RAF1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000053B1E8 RAF1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 RAF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000028BB8 RAF1 25416803 26452132 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000028D811 RAF1 25416803 27448964 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS00001F0C23 RAF1 25416803 27982429 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
LATS1 RAF1 22135298 phosphorylation N/A PhosphoSite
RAF1 RAF1 22135298 phosphorylation N/A PhosphoSite
RAF1 KLF10 22135298 phosphorylation N/A PhosphoSite
RAF1 BAD 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RAF1 MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RAF1 EEF1A2 22135298 phosphorylation N/A PhosphoSite
RAF1 MYC 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RAF1 PPP1R12A 22135298 phosphorylation N/A PhosphoSite
PRKACA RAF1 22135298 phosphorylation N/A PhosphoSite
MAPK3 RAF1 22135298 phosphorylation N/A PhosphoSite
SRC RAF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
KSR1 RAF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K1 RAF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PAK1 RAF1 22135298 phosphorylation N/A PhosphoSite
PRKCA RAF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDC37 RAF1 25361965 interaction type N/A PTMCode2
RAF1 CDC37 25361965 interaction type N/A PTMCode2
RAF1 HRAS 25361965 interaction type N/A PTMCode2
HRAS RAF1 25361965 interaction type N/A PTMCode2
RAF1 RRAS2 25361965 interaction type N/A PTMCode2
RRAS2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PEBP4 25361965 interaction type N/A PTMCode2
PEBP4 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PEBP1 25361965 interaction type N/A PTMCode2
PEBP1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 CSF1R 25361965 interaction type N/A PTMCode2
CSF1R RAF1 25361965 interaction type N/A PTMCode2
RAF1 RHEB 25361965 interaction type N/A PTMCode2
RHEB RAF1 25361965 interaction type N/A PTMCode2
RAF1 YWHAE 25361965 interaction type N/A PTMCode2
YWHAE RAF1 25361965 interaction type N/A PTMCode2
RAF1 KSR1 25361965 interaction type N/A PTMCode2
RAF1 AKT1 25361965 interaction type N/A PTMCode2
AKT1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PRKCA 25361965 interaction type N/A PTMCode2
RAF1 BRAF 25361965 interaction type N/A PTMCode2
BRAF RAF1 25361965 interaction type N/A PTMCode2
RAF1 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB RAF1 25361965 interaction type N/A PTMCode2
RAF1 PHB 25361965 interaction type N/A PTMCode2
PHB RAF1 25361965 interaction type N/A PTMCode2
RAF1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PRKCE 25361965 interaction type N/A PTMCode2
PRKCE RAF1 25361965 interaction type N/A PTMCode2
RAF1 YWHAG 25361965 interaction type N/A PTMCode2
YWHAG RAF1 25361965 interaction type N/A PTMCode2
BAD RAF1 25361965 interaction type N/A PTMCode2
RAF1 MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 RAF1 25361965 interaction type N/A PTMCode2
RAF1 ADCY5 25361965 interaction type N/A PTMCode2
ADCY5 RAF1 25361965 interaction type N/A PTMCode2
RAF1 CFLAR 25361965 interaction type N/A PTMCode2
CFLAR RAF1 25361965 interaction type N/A PTMCode2
RAF1 ZHX2 25361965 interaction type N/A PTMCode2
ZHX2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PPP2R1A 25361965 interaction type N/A PTMCode2
PPP2R1A RAF1 25361965 interaction type N/A PTMCode2
RAF1 HSP90AB1 25361965 interaction type N/A PTMCode2
HSP90AB1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PRKCD 25361965 interaction type N/A PTMCode2
PRKCD RAF1 25361965 interaction type N/A PTMCode2
RAF1 HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 RSU1 25361965 interaction type N/A PTMCode2
RSU1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 JAK1 25361965 interaction type N/A PTMCode2
JAK1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 SPRY4 25361965 interaction type N/A PTMCode2
SPRY4 RAF1 25361965 interaction type N/A PTMCode2
RAF1 RAP1A 25361965 interaction type N/A PTMCode2
RAP1A RAF1 25361965 interaction type N/A PTMCode2
RAF1 SRC 25361965 interaction type N/A PTMCode2
RAF1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 RAF1 25361965 interaction type N/A PTMCode2
RAF1 ETS2 25361965 interaction type N/A PTMCode2
ETS2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 CNKSR1 25361965 interaction type N/A PTMCode2
CNKSR1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 FYN 25361965 interaction type N/A PTMCode2
FYN RAF1 25361965 interaction type N/A PTMCode2
RAF1 SHOC2 25361965 interaction type N/A PTMCode2
SHOC2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 TSC22D3 25361965 interaction type N/A PTMCode2
TSC22D3 RAF1 25361965 interaction type N/A PTMCode2
RAF1 SPRY2 25361965 interaction type N/A PTMCode2
SPRY2 RAF1 25361965 interaction type N/A PTMCode2
MYC RAF1 25361965 interaction type N/A PTMCode2
RAF1 PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ RAF1 25361965 interaction type N/A PTMCode2
RAF1 CNKSR2 25361965 interaction type N/A PTMCode2
CNKSR2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 RAF1 25361965 interaction type N/A PTMCode2
RAF1 PAFAH1B1 25361965 interaction type N/A PTMCode2
PAFAH1B1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 GRB10 25361965 interaction type N/A PTMCode2
GRB10 RAF1 25361965 interaction type N/A PTMCode2
RAF1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 RAF1 25361965 interaction type N/A PTMCode2
MAPK1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 MAPK1 25361965 interaction type N/A PTMCode2
HSPA8 RAF1 25361965 interaction type N/A PTMCode2
RAF1 HSPA8 25361965 interaction type N/A PTMCode2
RRAS RAF1 25361965 interaction type N/A PTMCode2
RAF1 RRAS 25361965 interaction type N/A PTMCode2
YWHAH RAF1 25361965 interaction type N/A PTMCode2
RAF1 YWHAH 25361965 interaction type N/A PTMCode2
YWHAQ RAF1 25361965 interaction type N/A PTMCode2
RAF1 YWHAQ 25361965 interaction type N/A PTMCode2
BAG1 RAF1 25361965 interaction type N/A PTMCode2
RAF1 BAG1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 RAF1 14525934 15664191 20179103 20179161 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
KRT18 RAF1 14525934 15314064 24234451 25348397 phosphorylation reaction,physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
DYNLL1 RAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KRT19 RAF1 15314064 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
OIP5 RAF1 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HSPA8 RAF1 14525934 16093354 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SPRY2 RAF1 12717443 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SH3KBP1 RAF1 25348397 N/A physical interaction ComPPI
PACSIN3 RAF1 25348397 N/A physical interaction ComPPI
DYNLL2 RAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PAK2 RAF1 14525934 16837009 24234451 25348397 phosphorylation reaction experimental interaction detection,nuclear magnetic resonance,protein kinase assay,in vitro ComPPI,HPRD,IntAct
CIAO2B RAF1 25348397 N/A physical interaction ComPPI
PPP1CC RAF1 12374792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KRAS RAF1 14525934 24234451 25348397 25852190 9446616 association anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
PPP2R1A RAF1 25348397 N/A physical interaction ComPPI
AGTR1 RAF1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
EMD RAF1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP RAF1 25348397 N/A physical interaction ComPPI
NUDCD3 RAF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
YWHAG RAF1 10433554 11697890 14525934 17353931 24234451 25348397 25852190 8702721 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
CALM1 RAF1 25348397 N/A physical interaction ComPPI
XIAP RAF1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
WDR83 RAF1 25348397 N/A physical interaction ComPPI
HSP90AB1 RAF1 16330544 17979178 22939624 24234451 25348397 association,physical association anti bait coimmunoprecipitation,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
HIPK4 RAF1 25348397 N/A physical interaction ComPPI
BCL2L1 RAF1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
BAD RAF1 14525934 23397142 24234451 25241761 25348397 8929531 8929532 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
GPRASP2 RAF1 25348397 N/A physical interaction ComPPI
PAK1 RAF1 17097642 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay,in vitro,in vivo ComPPI,IntAct
ERBIN RAF1 25348397 N/A in vivo ComPPI
VAV1 RAF1 14525934 25348397 8900182 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK1 RAF1 14525934 15664191 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HRAS RAF1 12620389 14525934 15688026 16301319 18073111 18273062 19063885 19222999 19696784 20080631 20133694 20178605 22169110 24234451 24929361 25348397 25684575 7730360 8035810 8332187 8332195 8530446 8670882 8911690 9099670 9144171 9154803 9261098 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
MAPK8 RAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCA RAF1 14525934 25348397 8321321 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC RAF1 10205168 14525934 17097642 25348397 7517401 8876196 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB10 RAF1 10585452 14525934 25348397 9553107 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CRKL RAF1 23397142 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
LCK RAF1 14525934 25348397 8939988 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RRAS RAF1 25348397 N/A physical interaction ComPPI
ARAF RAF1 20130576 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCD RAF1 11171046 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK3 RAF1 14525934 25348397 9446616 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RB1 RAF1 10486249 14525934 21139044 24234451 25348397 9819434 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
AR RAF1 14525934 25348397 8349631 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TSC22D3 RAF1 12391160 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
COPS5 RAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCE RAF1 11350735 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBE2D2 RAF1 25348397 N/A physical interaction ComPPI
PRKACA RAF1 10576742 11971957 11997508 14525934 25348397 9091312 9710607 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKG1 RAF1 12237340 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAB RAF1 11697890 12620389 14525934 19595761 24234451 24255178 25348397 25852190 7644510 7882972 7935795 8085158 8702721 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
ACOX1 RAF1 25348397 N/A physical interaction ComPPI
YWHAZ RAF1 10887173 11697890 12360521 14525934 14688280 16306228 17979178 19049963 20052757 20679480 24234451 25348397 25852190 7628630 7935795 7939632 8085158 8601312 9153224 9261098 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,peptide array,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,lex-a dimerization assay,biochemical,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PRKAR1A RAF1 25348397 N/A physical interaction ComPPI
PDGFRB RAF1 14525934 23397142 24234451 2475255 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
ERAS RAF1 25348397 N/A physical interaction ComPPI
RRAS2 RAF1 10064593 11788587 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
IRS4 RAF1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRAS RAF1 10498616 14525934 20080631 24234451 25348397 N/A experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro ComPPI,HPRD,IntAct
RASD2 RAF1 25348397 N/A physical interaction ComPPI
PRKAA1 RAF1 11971957 14525934 25348397 9091312 9710607 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSP90AA1 RAF1 14525934 16093354 24234451 25036637 25348397 8408024 physical association experimental interaction detection,physical interaction,in vivo,luminescence based mammalian interactome mapping ComPPI,HPRD,IntAct
JAK1 RAF1 14525934 25348397 9446616 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BAG1 RAF1 24234451 25348397 8692945 physical association two hybrid,coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
ILK RAF1 23455922 24234451 25348397 25852190 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
STIP1 RAF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSPA5 RAF1 18064632 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,cosedimentation,pull down,physical interaction ComPPI,IntAct
PHB RAF1 10523633 14525934 24234451 24568222 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RBL2 RAF1 14525934 25348397 9819434 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 RAF1 11427728 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K1 RAF1 11604401 14525934 16093354 17724343 17979178 19197339 23934108 24234451 24746704 25155755 25348397 26496610 7731720 8157000 8394352 8621729 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,biochemical,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MYC RAF1 14525934 17314511 24234451 25348397 9315742 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
PEBP1 RAF1 14525934 17097642 21831839 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,peptide array,pull down,surface plasmon resonance,physical interaction,in vitro ComPPI,HPRD,IntAct
PEBP4 RAF1 19197339 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MAPK8IP3 RAF1 10523642 11044439 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KSR2 RAF1 12975377 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPP2CB RAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EEF1A1 RAF1 17332776 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CACYBP RAF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MAP2K2 RAF1 11909642 14525934 21988832 24234451 24746704 25348397 8157000 8393135 9671314 9808624 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCZ RAF1 10620507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK6 RAF1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
VDAC1 RAF1 12079506 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PPP2R5C RAF1 16239230 24234451 25348397 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,phosphatase assay ComPPI,IntAct
PPP2CA RAF1 16239230 24234451 25348397 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,physical interaction,phosphatase assay ComPPI,IntAct
PKM RAF1 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RANBP9 RAF1 25348397 N/A physical interaction ComPPI
RAP1A RAF1 10454553 14525934 24234451 25348397 7791872 8756332 9115221 9867809 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RAP2A RAF1 14525934 25348397 9523700 N/A two hybrid,two hybrid ComPPI,HPRD
CNKSR2 RAF1 25348397 N/A physical interaction ComPPI
PHKA2 RAF1 25348397 N/A physical interaction ComPPI
XPO1 RAF1 25348397 N/A physical interaction ComPPI
YWHAQ RAF1 11697890 17353931 24234451 25348397 25852190 7760835 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,biochemical ComPPI,IntAct
RBBP8 RAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK7 RAF1 10531364 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HUWE1 RAF1 25348397 N/A physical interaction ComPPI
NEDD4L RAF1 25348397 N/A physical interaction ComPPI
ARRB2 RAF1 11226259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
YY1 RAF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGFR RAF1 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SCNN1B RAF1 25348397 N/A physical interaction ComPPI
YWHAH RAF1 11697890 14525934 17979178 24234451 25348397 25852190 26496610 8702721 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
SFN RAF1 11697890 15778465 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,biochemical,tandem affinity purification ComPPI,IntAct
YWHAE RAF1 11697890 14525934 15459208 24234451 25348397 25852190 7644510 8702721 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
IL2RB RAF1 14525934 1639773 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
JAK2 RAF1 10205168 11134016 14525934 25348397 8876196 9689060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCAPG2 RAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 HSPA4 14525934 16093354 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAF1 CDC25A 10373531 14525934 24234451 25348397 7644510 9230211 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD,IntAct
RAF1 STK3 14525934 15618521 24234451 24929361 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RAF1 ADCY6 14525934 15470083 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAF1 GNB2 14525934 25348397 7782277 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAF1 KRT8 14525934 15314064 24234451 25348397 association experimental interaction detection,in vivo ComPPI,HPRD,IntAct
RAF1 KSR1 14525934 15520859 24234451 24929361 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RAF1 MAP3K1 10969079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAF1 FYN 14525934 25348397 7517401 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAF1 NR3C1 11005817 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAF1 INSR 11409918 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAF1 BCL2 14525934 25348397 8910675 8929532 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAF1 AKT1 10576742 14525934 19058874 19197339 24234451 25241761 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RAF1 BRAF 11325826 14525934 16803888 20130576 20141835 22169110 22510884 23680146 23934108 24234451 25155755 25348397 26466569 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,solid phase assay ComPPI,HPRD,IntAct
RAF1 NRAS 14525934 18641128 20080631 21478863 24234451 25348397 9488663 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
RAF1 RSU1 14525934 25348397 8816460 N/A experimental interaction detection,in vitro ComPPI,HPRD
RAF1 PAK3 10205168 11733498 14525934 25348397 9234708 9823899 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAF1 RHEB 14525934 16803888 19222999 24234451 25348397 9001246 N/A two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RAF1 EFEMP1 12620389 24234451 25348397 physical association two hybrid ComPPI,IntAct
RAF1 SHOC2 10783161 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAF1 RFXANK 10329666 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
RAF1 DMPK 10869570 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAF1 STK26 11306563 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RAF1 COPS3 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
RAF1 INTS10 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
RAF1 SPRY4 12717443 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAF1 PEX5L 14525934 15302887 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAF1 TIMM50 12620389 14525934 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RAF1 PBK 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
RAF1 CNKSR1 25348397 N/A physical interaction ComPPI
RAF1 CCT3 12620389 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RAF1 LRPAP1 25348397 N/A physical interaction ComPPI
RAF1 HSP90AA2P 25348397 N/A physical interaction ComPPI
RAF1 PRPF6 25348397 N/A physical interaction ComPPI
RAF1 LTK 25348397 N/A physical interaction ComPPI
RAF1 BIRC2 25348397 N/A physical interaction ComPPI
RAF1 BIRC3 25348397 N/A physical interaction ComPPI
RAF1 STUB1 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
RAF1 EEF1A1P5 25348397 N/A physical interaction ComPPI
RAF1 SGK1 25348397 N/A physical interaction ComPPI
RAF1 NEDD4 25348397 N/A physical interaction ComPPI
RAF1 BRAP 25348397 N/A physical interaction ComPPI
RAF1 LATS1 25348397 N/A physical interaction ComPPI
RAF1 HSPD1 25348397 N/A physical interaction ComPPI
RAF1 BCL6 25348397 N/A physical interaction ComPPI
RAF1 BIRC7 25348397 N/A physical interaction ComPPI
RAF1 MMS19 25348397 N/A physical interaction ComPPI
RAF1 PPP2R2B 25348397 N/A physical interaction ComPPI
RAF1 CDK20 25348397 N/A physical interaction ComPPI
RAF1 TBXA2R 14525934 16413928 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RAF1 CDC37 17979178 24189400 24234451 25036637 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
RAF1 TMEM70 25348397 N/A physical interaction ComPPI
RAF1 NPLOC4 25348397 N/A physical interaction ComPPI
RAF1 DCAF8 25348397 N/A physical interaction ComPPI
RAF1 PURA 25348397 N/A physical interaction ComPPI
RAF1 FYCO1 25348397 N/A physical interaction ComPPI
RAF1 MYBPC1 25348397 N/A physical interaction ComPPI
RAF1 COPS7A 25348397 N/A physical interaction ComPPI
RAF1 MOV10 25348397 N/A physical interaction ComPPI
RAF1 NXF1 25348397 N/A physical interaction ComPPI
RAF1 CCT8 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 DNAJA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 LOX 25348397 N/A physical interaction ComPPI
RAF1 CASZ1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAF1 MRC2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAF1 PDLIM2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAF1 HERC2 25348397 N/A physical interaction ComPPI
RAF1 HERC2P3 25348397 N/A physical interaction ComPPI
RAF1 PCDH7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 MAD2L1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 EEF1E1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 SS18L2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 NUP133 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 RPGRIP1L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 NUP107 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 MSH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 LAS1L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 AMER1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 NUP160 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 EIF3D 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 SPATA7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 NPHP4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 IQCB1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAF1 RMDN3 25348397 N/A physical interaction ComPPI
RAF1 TRIM25 25348397 N/A physical interaction ComPPI
RAF1 CDC25B 25348397 N/A experimental interaction detection,physical interaction,biochemical ComPPI
RAF1 PAQR3 17724343 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 RALGDS 19075231 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RAF1 CPS1 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
RAF1 RCAN1 25348397 N/A pull down ComPPI
RAF1 NFATC3 24234451 24330068 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
RAF1 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RAF1 BAG2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RAF1 PSMD2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RAF1 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NUDT14 RAF1 12620389 14525934 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
CFLAR RAF1 10837247 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo ComPPI,HPRD,IntAct
GNG4 RAF1 14525934 25348397 7782277 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FKBPL RAF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CALU RAF1 24234451 25348397 25852190 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAF1 RAF1 11971957 14525934 16093354 17979178 20130576 22169110 22510884 24234451 8349614 9091312 9710607 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,tandem affinity purification HPRD,IntAct
NUDCD1 RAF1 24234451 29021621 association anti tag coimmunoprecipitation IntAct
RAF1 AGTR1 11226259 27898060 8753867 N/A N/A OmniPath
SRC RAF1 10205168 10998357 11134016 11259591 11274179 11971957 12551923 12801936 16189514 17097642 17428866 27898060 7517401 7692235 8876196 9091312 9689060 stimulant N/A OmniPath
PRKACA RAF1 10576742 10862777 11971957 11997508 18669648 18691976 18767875 19007248 19651622 20068231 20166139 20230923 27898060 7935389 9001246 9091312 9710607 9922370 inhibition,stimulant N/A OmniPath
LCK RAF1 27898060 7935389 8939988 stimulant N/A OmniPath
PRKCA RAF1 12551925 1437148 27898060 7935389 8288587 8321321 9447975 992237 inhibition,stimulant N/A OmniPath
PTPN1 RAF1 27898060 7604263 N/A N/A OmniPath
PRKCB RAF1 27898060 8288587 stimulant N/A OmniPath
RAF1 PRKCE 11350735 27898060 N/A N/A OmniPath
YWHAG RAF1 10433554 10620507 11697890 15664191 16041367 16093354 17353931 25852190 27898060 8702721 N/A N/A OmniPath
RAF1 ARRB2 11226259 27898060 N/A N/A OmniPath
CDC25A RAF1 10373531 27898060 7644510 7744247 9230211 inhibition N/A OmniPath
RAF1 RB1 10486249 10523633 15485920 19058874 21139044 27898060 9819434 inhibition N/A OmniPath
RIPK2 RAF1 10559258 27898060 N/A N/A OmniPath
HRAS RAF1 10369681 10545207 10783161 10882715 10922060 11435472 11733498 12173045 12379659 12391160 12620389 14654780 14724584 15031288 15235600 15664191 15688026 16041367 16301319 16405865 16803888 17984326 18073111 18273062 19063885 19222999 19696784 20080631 20133694 20178605 21779497 24470255 25684575 27898060 7523381 7730360 7862125 7969158 8035810 8332187 8332195 8530446 8628317 8670882 8911690 9020159 9099670 9144171 9150145 9154803 9261098 9523700 stimulant N/A OmniPath
RAF1 MYC 17314511 27898060 9315742 N/A N/A OmniPath
RAF1 MAP2K1 10359597 10409742 10757792 10958680 11435472 11604401 11684694 1326789 14636584 15485920 15866172 16093354 17053865 17192257 17724343 17979178 18337766 18556463 18691976 19058874 19197339 20212043 20956560 21336309 23934108 24746704 26496610 27898060 7731720 8131746 8157000 8394352 8621729 9311917 9677429 stimulant N/A OmniPath
MAP3K1 RAF1 10969079 27898060 N/A N/A OmniPath
RAF1 CASP9 15674327 27898060 N/A N/A OmniPath
RAF1 BCL2 12488548 15849194 27898060 8910675 8929532 N/A N/A OmniPath
RAF1 PIN1 15664191 27898060 N/A N/A OmniPath
RAF1 KSR2 12975377 27898060 N/A N/A OmniPath
KSR2 RAF1 12975377 27898060 stimulant N/A OmniPath
RAF1 BRAF 11325826 16803888 18332145 20130576 20141835 20212043 22169110 22510884 23153539 23680146 23934108 25155755 26466569 27898060 N/A N/A OmniPath
BRAF RAF1 11325826 16803888 18332145 20130576 20141835 20212043 22169110 22510884 23153539 23680146 23934108 25155755 26466569 27898060 N/A N/A OmniPath
RAF1 MAP2K2 11909642 16293107 16364241 17116858 18039929 18669648 19058874 19369195 21988832 27898060 8157000 8393135 9671314 9808624 stimulant N/A OmniPath
RAF1 BAD 10826997 12107820 12175651 12444011 12767520 15849194 16931767 17535812 19030972 19667065 21540285 23397142 25241761 27898060 8929531 8929532 inhibition,stimulant N/A OmniPath
BAD RAF1 10826997 12107820 12175651 12444011 12767520 15849194 16931767 19030972 19667065 21540285 23397142 25241761 27898060 8929531 8929532 N/A N/A OmniPath
RAF1 PEBP1 10490027 10757792 11585904 12551925 14654844 17097642 27898060 N/A N/A OmniPath
PEBP1 RAF1 10490027 10757792 11585904 12551925 14654844 17097642 27898060 inhibition,stimulant N/A OmniPath
RAF1 AKT1 10576742 12087097 16854453 19058874 19197339 25241761 27898060 N/A N/A OmniPath
AKT1 RAF1 10576741 10576742 10618391 11971957 11997508 12048182 12087097 16854453 18669648 18691976 18767875 19058874 19197339 20068231 20230923 22798428 25241761 27898060 inhibition N/A OmniPath
RAF1 XIAP 16964381 19011619 25241761 27898060 stimulant N/A OmniPath
XIAP RAF1 16964381 19011619 25241761 27898060 N/A N/A OmniPath
RAF1 MAP3K5 11427728 27898060 inhibition N/A OmniPath
MAP3K5 RAF1 11427728 27898060 N/A N/A OmniPath
RAF1 STK4 22898666 27898060 inhibition N/A OmniPath
PRKCG RAF1 17053865 27898060 8288587 stimulant N/A OmniPath
RHEB RAF1 15150271 15854902 16803888 19222999 27898060 9001246 stimulant N/A OmniPath
RAF1 MAPK3 11409918 18039929 19058874 27898060 9446616 stimulant N/A OmniPath
MAPK3 RAF1 11409918 15664191 16407412 19058874 27898060 9446616 9922370 inhibition,stimulant N/A OmniPath
PRMT5 RAF1 21917714 27898060 N/A N/A OmniPath
HSP90AA1 RAF1 15618521 16093354 16330544 16504566 17409432 17699868 18266962 19011619 20039095 20159553 22939624 23118896 24462205 25036637 27898060 8408024 8962087 stimulant N/A OmniPath
RAF1 STK3 15618521 17889669 20086174 20212043 27898060 inhibition N/A OmniPath
PPP1CB RAF1 27898060 7604263 N/A N/A OmniPath
RAF1 GRB10 10585452 27898060 9553107 N/A N/A OmniPath
GRB10 RAF1 10585452 27898060 9553107 N/A N/A OmniPath
NRAS RAF1 10882715 18641128 20080631 21478863 21779497 27898060 7811320 8636091 8876196 9001246 9488663 9525741 9867809 stimulant N/A OmniPath
PPP5C RAF1 16892053 25036637 27898060 inhibition N/A OmniPath
PPP1CA RAF1 16630891 27898060 7604263 stimulant N/A OmniPath
BAG2 RAF1 12502846 14978028 25036637 27898060 8692945 stimulant N/A OmniPath
RAF1 MAPK1 10958680 11409918 15664191 15849194 16093354 18039929 18669648 18691976 18767875 19058874 19651622 20068231 27898060 stimulant N/A OmniPath
MAPK1 RAF1 10801873 10958680 11409918 15664191 15849194 16093354 17081983 18669648 18691976 18767875 19058874 19651622 19690332 20068231 21917714 27898060 8349614 9922370 inhibition,stimulant N/A OmniPath
PAK1 RAF1 10205168 10801448 11134016 11733498 11948406 12551923 15849194 17097642 18465753 18775988 21917714 27898060 9234708 9823899 stimulant N/A OmniPath
PPP2R5D RAF1 16239230 27898060 stimulant N/A OmniPath
RRAS RAF1 10848612 19805522 27898060 7730360 8035810 8530446 8911690 9099670 stimulant N/A OmniPath
PPP2CA RAF1 16239230 27898060 7604263 stimulant N/A OmniPath
AKT2 RAF1 10576742 27898060 inhibition N/A OmniPath
PAK2 RAF1 10712905 16837009 1683701 27898060 stimulant N/A OmniPath
GSK3B RAF1 10576742 11447113 11971957 12801936 15258589 16093354 27898060 8321321 N/A N/A OmniPath
RAF1 CAMK2A 12954639 27898060 N/A N/A OmniPath
JAK2 RAF1 10205168 11134016 27898060 8876196 9689060 stimulant N/A OmniPath
YWHAQ RAF1 10620507 10757792 11697890 14688280 15618521 16041367 16093354 17353931 20679480 25852190 27898060 7479742 7760835 8601312 8663231 N/A N/A OmniPath
RAF1 RRAS2 10064593 10557073 10783161 11788587 12620389 27898060 N/A N/A OmniPath
KSR1 RAF1 11134016 11376654 11478855 11971957 12719581 15520859 1552086 15664191 27898060 7477354 9094715 9823899 stimulant N/A OmniPath
LTK RAF1 27898060 8084603 stimulant N/A OmniPath
IL2RB RAF1 1639773 27898060 N/A N/A OmniPath
RAF1 SPRY4 12717443 27898060 N/A N/A OmniPath
SPRY4 RAF1 12717443 27898060 inhibition N/A OmniPath
SPRY2 RAF1 12717443 27898060 N/A N/A OmniPath
RAF1 SPRY2 12717443 27898060 N/A N/A OmniPath
RAF1 PPP1CC 12374792 27898060 N/A N/A OmniPath
PPP1CC RAF1 12374792 27898060 7604263 N/A N/A OmniPath
RAF1 SHOC2 10783161 16301319 25022756 27898060 N/A N/A OmniPath
SHOC2 RAF1 10783161 16301319 25022756 27898060 N/A N/A OmniPath
PAK3 RAF1 10205168 11733498 27898060 9234708 9823899 stimulant N/A OmniPath
KRAS RAF1 10783161 10882715 10958680 16041367 16093354 16293107 1629311 19029954 20080631 23153539 25852190 27898060 9446616 stimulant N/A OmniPath
RAF1 KRAS 10783161 10882715 10958680 16041367 16093354 1629311 19029954 20080631 23153539 25852190 27898060 9446616 N/A N/A OmniPath
YWHAH RAF1 10620507 11697890 11969417 12801936 16041367 16093354 17979178 20679480 25852190 26496610 27898060 8601312 8702721 inhibition N/A OmniPath
PRKAA1 RAF1 11971957 19007248 19651622 20068231 20166139 27898060 9091312 9710607 inhibition,stimulant N/A OmniPath
RAF1 MAP4K1 27898060 7624324 stimulant N/A OmniPath
WDR83 RAF1 15118098 27898060 stimulant N/A OmniPath
PKN1 RAF1 11733498 15849194 27898060 stimulant N/A OmniPath
RAF1 PHB 10523633 16041367 24568222 27898060 N/A N/A OmniPath
PHB RAF1 10523633 16041367 24568222 27898060 N/A N/A OmniPath
RAF1 TSC22D3 12391160 19380724 27898060 N/A N/A OmniPath
TSC22D3 RAF1 12391160 19380724 27898060 inhibition N/A OmniPath
CERK RAF1 27898060 7477354 stimulant N/A OmniPath
CNKSR1 RAF1 15075335 15845549 27898060 9115393 stimulant N/A OmniPath
PPP2R2A RAF1 16239230 27898060 stimulant N/A OmniPath
CNKSR2 RAF1 14597674 27898060 stimulant N/A OmniPath
PPP2CB RAF1 21988832 27898060 7604263 N/A N/A OmniPath
RAF1 KLF10 23994618 27898060 N/A N/A OmniPath

Visualization










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