GENE：RAG2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RAG2 |
| FullNmae | recombination activating 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9832 |
| EnsembleID | ENSG00000175097 |
| Uniprot | P55895 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RAG2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RAG2 | GO:0002313,GO:0002326,GO:0002331,GO:0002358,GO:0002360,GO:0003682,GO:0005546,GO:0005547,GO:0005654,GO:0006325,GO:0008270,GO:0030183,GO:0033077,GO:0033085,GO:0033151,GO:0033151,GO:0035064,GO:0035091,GO:0035265,GO:0042742,GO:0043325,GO:0043565,GO:0046622,GO:0061630,GO:0080025,GO:0097519,GO:1904155 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RAG2 | hsa:5897 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| RAG2 | hsa:5897 | path:hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | RAG2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | RAG2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOS | RAG2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HMGA1 | RAG2 | 15713121 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LEF1 | RAG2 | 12244173 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | RAG2 | 12044781 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PAX5 | RAG2 | 11094072 12044781 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | RAG2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKDC | RAG2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| SKP2 | RAG2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAG2 | SKP2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAG2 | KPNA1 | 25361965 | interaction type | N/A | PTMCode2 |
| KPNA1 | RAG2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAG1 | RAG2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAG2 | RAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAG1 | RAG2 | 12861017 14525934 25348397 9036966 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| RAG2 | SKP2 | 25348397 | N/A | physical interaction | ComPPI |
| RAG2 | DCAF1 | 25348397 | N/A | physical interaction | ComPPI |
| RAG2 | DDB1 | 25348397 | N/A | physical interaction | ComPPI |
| RAG2 | IPO5 | 12861017 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| RAG2 | MTOR | 22790199 27898060 | stimulant | N/A | OmniPath |
| PRKDC | RAG2 | 17562296 27898060 | N/A | N/A | OmniPath |