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GENE：SERPINA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SERPINA1
FullNmae serpin family A member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8941
EnsembleID ENSG00000197249
Uniprot P01009

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SERPINA1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SERPINA1 GO:0002020,GO:0004867,GO:0004867,GO:0004867,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0006953,GO:0007596,GO:0010951,GO:0030134,GO:0031093,GO:0033116,GO:0042802,GO:0043231,GO:0062023,GO:0070062,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SERPINA1 hsa:5265 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMM SERPINA1 15494398 23180781 protein cleavage,physical association comigration in sds page InnateDB
SERPINA1 HNF4A 14988562 23180781 physical association anti tag coimmunoprecipitation InnateDB
SERPINA1 HNF1A 14988562 23180781 physical association anti tag coimmunoprecipitation InnateDB
LGALS3 SERPINA1 18263896 23180781 physical association pull down InnateDB
SERPINA1 ADAMTS4 16099106 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
PITX3 SERPINA1 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SERPINA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 SERPINA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SERPINA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SERPINA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SERPINA1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000060AABB SERPINA1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F24A9 SERPINA1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001EE123 SERPINA1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037E170 SERPINA1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005F1B8C SERPINA1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 SERPINA1 25348397 N/A physical interaction ComPPI
CA8 SERPINA1 25348397 N/A physical interaction ComPPI
VCP SERPINA1 25348397 N/A physical interaction ComPPI
DERL2 SERPINA1 14525934 16449194 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FBXO2 SERPINA1 25348397 N/A physical interaction ComPPI
SMAD4 SERPINA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTSG SERPINA1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP7 SERPINA1 14525934 25348397 27898060 7980522 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CTRB1 SERPINA1 14525934 25348397 27898060 6983488 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CELA1 SERPINA1 1079736 14525934 25348397 27898060 6153632 6191979 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
ELANE SERPINA1 10867014 14525934 16321984 24234451 25348397 27898060 N/A experimental interaction detection,physical interaction,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD,IntAct,OmniPath
KLK3 SERPINA1 11317942 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRSS2 SERPINA1 14525934 25348397 2610933 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SDC2 SERPINA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CANX SERPINA1 17380188 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA5 SERPINA1 25348397 N/A physical interaction ComPPI
SERPINA1 PRTN3 12114510 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SERPINA1 PRSS1 11057674 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SERPINA1 MMP26 12119297 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SERPINA1 PRSS3 11057674 12860985 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SERPINA1 ADAMTS4 14525934 16099106 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SERPINA1 KLK5 12890555 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SERPINA1 LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SERPINA1 DERL3 14525934 16449193 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SERPINA1 RAP2A 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPINA1 DERL1 25348397 N/A physical interaction ComPPI
SERPINA1 OS9 18264092 19914915 21172656 24899641 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SERPINA1 ERLEC1 18264092 19917667 23356641 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SERPINA1 VKORC1 25348397 N/A physical interaction ComPPI
SERPINA1 SSR1 17380188 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SERPINA1 FN1 25348397 N/A physical interaction ComPPI
SERPINA1 ATP5F1C 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPINA1 GSDMB 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPINA1 ECHS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPINA1 RCHY1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERPINA1 LAMTOR5 25348397 N/A physical interaction ComPPI
SERPINA1 GDPD1 25348397 N/A physical interaction ComPPI
SERPINA1 ZNF558 25348397 N/A physical interaction ComPPI
SERPINA1 ICE2 25348397 N/A physical interaction ComPPI
SERPINA1 ALDH2 25348397 N/A physical interaction ComPPI
SERPINA1 SYVN1 25348397 N/A physical interaction ComPPI
SERPINA1 SQSTM1 25348397 N/A physical interaction ComPPI
SERPINA1 DDX31 25348397 N/A physical interaction ComPPI
SERPINA1 SNX27 25348397 N/A physical interaction ComPPI
SERPINA1 GOT1L1 25348397 N/A physical interaction ComPPI
SERPINA1 UPF3A 25348397 N/A physical interaction ComPPI
SERPINA1 SRP54 25348397 N/A physical interaction ComPPI
SERPINA1 CFTR 25348397 N/A physical interaction ComPPI
SERPINA1 TCF3 25348397 N/A two hybrid ComPPI
SERPINA1 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SERPINA1 PPP1CA 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
MAPK6 SERPINA1 25348397 N/A physical interaction ComPPI
PLK2 SERPINA1 25348397 N/A physical interaction ComPPI
DDX19B SERPINA1 25348397 N/A physical interaction ComPPI
MIS12 SERPINA1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SERPINA1 SERPINA1 11057674 14525934 18923394 21909074 22405009 24234451 2785270 6332197 6966283 6976274 6982267 6983488 physical association cross-linking study,experimental interaction detection,x-ray crystallography,comigration in non denaturing gel electrophoresis HPRD,IntAct
MMP11 SERPINA1 14525934 7523394 N/A experimental interaction detection HPRD
SERPINA1 UGGT1 27898060 9148970 N/A N/A OmniPath
SERPINA1 LRP1 15131125 27898060 8626456 stimulant N/A OmniPath

Visualization










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