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GENE：SNCA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SNCA
FullNmae synuclein alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11138
EnsembleID ENSG00000145335
Uniprot P37840

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SNCA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNCA ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNCA cuproptosis 40221422 RT-qPCR confirmed increased SNCA expression during cuproptosis. retulator signature
SNCA cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
SNCA cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.22 database.
SNCA autophagy 37626481 Moreover, SNCA overexpression reversed SNHG1 silencing-induced cell autophagy in MPP+-induced human neuroblastoma cells upon RES pre-incubation. retulator signature
SNCA autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SNCA GO:0000122,GO:0000149,GO:0000287,GO:0000976,GO:0001774,GO:0001921,GO:0001956,GO:0003779,GO:0004860,GO:0005507,GO:0005509,GO:0005515,GO:0005543,GO:0005576,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005829,GO:0005886,GO:0005938,GO:0006469,GO:0006631,GO:0006638,GO:0006644,GO:0006919,GO:0007006,GO:0007268,GO:0008198,GO:0008270,GO:0008289,GO:0008289,GO:0008344,GO:0009410,GO:0010040,GO:0010517,GO:0010642,GO:0014048,GO:0014059,GO:0015629,GO:0016020,GO:0016079,GO:0016082,GO:0016234,GO:0016491,GO:0019894,GO:0022898,GO:0030424,GO:0030426,GO:0030544,GO:0030672,GO:0031092,GO:0031115,GO:0031623,GO:0031648,GO:0032026,GO:0032410,GO:0032496,GO:0032769,GO:0032991,GO:0033138,GO:0034341,GO:0034599,GO:0035493,GO:0035543,GO:0040012,GO:0042393,GO:0042416,GO:0042775,GO:0042802,GO:0042802,GO:0043014,GO:0043025,GO:0043027,GO:0043030,GO:0043065,GO:0043066,GO:0043154,GO:0043524,GO:0043679,GO:0045807,GO:0045920,GO:0045921,GO:0048156,GO:0048169,GO:0048471,GO:0048488,GO:0048488,GO:0048489,GO:0050729,GO:0050808,GO:0050812,GO:0051179,GO:0051219,GO:0051262,GO:0051281,GO:0051402,GO:0051583,GO:0051585,GO:0051612,GO:0051621,GO:0051622,GO:0060079,GO:0060090,GO:0060291,GO:0060732,GO:0070495,GO:0070555,GO:0070840,GO:0071280,GO:0071872,GO:0071902,GO:0097435,GO:0098794,GO:0099512,GO:1902957,GO:1903136,GO:1903136,GO:1903284,GO:1903285,GO:1903421,GO:1903426,GO:1904377,GO:1904715,GO:1905606,GO:1990000

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SNCA hsa:6622 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SNCA hsa:6622 path:hsa05012 Parkinson disease - Homo sapiens (human)
SNCA hsa:6622 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIN1 SNCA 16365047 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
SNCA SNCAIP 16365047 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
SNCA UBE2D2 15064394 18070888 23180781 ubiquitination reaction enzymatic study InnateDB
SNCA SIAH2 15064394 18070888 23180781 ubiquitination reaction enzymatic study InnateDB
SNCA SIAH1 18070888 23180781 ubiquitination reaction enzymatic study InnateDB
MAPK1 SNCA 12121974 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 SNCA 12121974 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNCA MAPK8 12121974 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNCA ELK1 11279280 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SNCA FYN 20005715 interaction type N/A PSP
SNCA LYN 20005715 interaction type N/A PSP
SNCA CSNK2A2 20005715 interaction type N/A PSP
SNCA GRK2 20005715 interaction type N/A PSP
SNCA MAPK3 20005715 interaction type N/A PSP,SignaLink
SNCA MAPK1 20005715 interaction type N/A PSP
SNCA GRK5 20005715 interaction type N/A PSP
SNCA GRK6 20005715 interaction type N/A PSP
SNCA SYK 20005715 interaction type N/A PSP
SNCA MAPK8 20005715 interaction type N/A PSP,SignaLink
SNCA CSNK1D 20005715 interaction type N/A PSP
SNCA CSNK2A1 20005715 interaction type N/A PSP
SNCA PRKCE 20005715 interaction type N/A PSP
SNCA PLD1 20005715 interaction type N/A PSP
SNCA PTK2B 20005715 interaction type N/A PSP
SNCA GRK1 20005715 interaction type N/A PSP
SNCA GRK2 20005715 20005715 N/A N/A SignaLink
SNCA CSNK1D 20005715 20005715 N/A N/A SignaLink
SNCA CSNK2A1 20005715 20005715 N/A N/A SignaLink
SNCA FYN 11162638 20005715 20005715 21071413 N/A N/A SignaLink
SNCA GRK5 10852916 20005715 20005715 21071413 N/A N/A SignaLink
SNCA GRK6 10852916 20005715 20005715 21071413 N/A N/A SignaLink
SNCA MAPK1 20005715 20005715 N/A N/A SignaLink
SNCA PTK2B 20005715 20005715 N/A N/A SignaLink
SNCA SYK 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SNCA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 SNCA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SNCA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 SNCA 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SNCA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000027352D SNCA 25416803 25541488 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B SNCA 25416803 25541488 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2A SNCA 22135298 phosphorylation N/A PhosphoSite
CSNK2A1 SNCA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SYK SNCA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SRC SNCA 22135298 phosphorylation N/A PhosphoSite
PTK2B SNCA 22135298 phosphorylation N/A PhosphoSite
ABL1 SNCA 22135298 phosphorylation N/A PhosphoSite
GSK3B SNCA 22135298 phosphorylation N/A PhosphoSite
PLK2 SNCA 22135298 phosphorylation N/A PhosphoSite
GRK5 SNCA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
DYRK1A SNCA 22135298 phosphorylation N/A PhosphoSite
PLK1 SNCA 22135298 phosphorylation N/A PhosphoSite
GRK2 SNCA 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 SNCA 22135298 phosphorylation N/A PhosphoSite
FYN SNCA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK3 SNCA 22135298 phosphorylation N/A PhosphoSite
SNCA MAPT 25361965 interaction type N/A PTMCode2
MAPT SNCA 25361965 interaction type N/A PTMCode2
SNCA PLD1 25361965 interaction type N/A PTMCode2
PLD1 SNCA 25361965 interaction type N/A PTMCode2
SNCA TOR1A 25361965 interaction type N/A PTMCode2
TOR1A SNCA 25361965 interaction type N/A PTMCode2
SNCA FYN 25361965 interaction type N/A PTMCode2
SNCA FGR 25361965 interaction type N/A PTMCode2
FGR SNCA 25361965 interaction type N/A PTMCode2
SNCA SYK 25361965 interaction type N/A PTMCode2
SNCA TH 25361965 interaction type N/A PTMCode2
TH SNCA 25361965 interaction type N/A PTMCode2
SNCA GRK5 25361965 interaction type N/A PTMCode2
KLK6 SNCA 25361965 interaction type N/A PTMCode2
SNCA KLK6 25361965 interaction type N/A PTMCode2
MAPK1 SNCA 25361965 interaction type N/A PTMCode2
SNCA MAPK1 25361965 interaction type N/A PTMCode2
SNCA CSNK2A1 25361965 interaction type N/A PTMCode2
SNCAIP SNCA 25361965 interaction type N/A PTMCode2
SNCA SNCAIP 25361965 interaction type N/A PTMCode2
CYCS SNCA 25361965 interaction type N/A PTMCode2
SNCA CYCS 25361965 interaction type N/A PTMCode2
CSNK2A2 SNCA 25361965 interaction type N/A PTMCode2
SNCA CSNK2A2 25361965 interaction type N/A PTMCode2
BAD SNCA 25361965 interaction type N/A PTMCode2
SNCA BAD 25361965 interaction type N/A PTMCode2
COL25A1 SNCA 25361965 interaction type N/A PTMCode2
SNCA COL25A1 25361965 interaction type N/A PTMCode2
ELK1 SNCA 25361965 interaction type N/A PTMCode2
SNCA ELK1 25361965 interaction type N/A PTMCode2
YWHAH SNCA 25361965 interaction type N/A PTMCode2
SNCA YWHAH 25361965 interaction type N/A PTMCode2
SIAH2 SNCA 25361965 interaction type N/A PTMCode2
SNCA SIAH2 25361965 interaction type N/A PTMCode2
APP SNCA 25361965 interaction type N/A PTMCode2
SNCA APP 25361965 interaction type N/A PTMCode2
RPS27A SNCA 25361965 interaction type N/A PTMCode2
SNCA RPS27A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 SNCA 25348397 N/A physical interaction ComPPI
PDE4DIP SNCA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF3G SNCA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SAP30BP SNCA 25348397 N/A physical interaction ComPPI
DYNLL1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 SNCA 17893145 21832061 22776201 22843682 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDC42EP2 SNCA 25348397 N/A physical interaction ComPPI
FXR2 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CRYAB SNCA 15236975 20197038 21905118 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VIM SNCA 16678164 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
PSMC3 SNCA 25348397 N/A physical interaction ComPPI
RAB3A SNCA 15207266 15854772 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TUBB SNCA 25348397 N/A physical interaction ComPPI
TRAF6 SNCA 25348397 N/A physical interaction ComPPI
MCM5 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTB SNCA 25348397 N/A physical interaction ComPPI
CALM1 SNCA 25348397 N/A physical interaction ComPPI
LAMTOR4 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3B SNCA 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CYCS SNCA 10506125 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CTNND1 SNCA 25348397 N/A physical interaction ComPPI
BCL2L1 SNCA 11742726 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BAD SNCA 10407019 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CSNK1D SNCA 10617630 10852916 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RABAC1 SNCA 21798244 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,phage display,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
HSPB8 SNCA 25348397 N/A physical interaction ComPPI
MAPK1 SNCA 11279280 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SYK SNCA 11162638 11744621 12096713 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTK2B SNCA 11162638 11744621 12096713 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SIAH2 SNCA 25348397 N/A physical interaction ComPPI
MAPK8 SNCA 25348397 N/A physical interaction ComPPI
LYN SNCA 11162638 11744621 12096713 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC SNCA 25348397 N/A physical interaction ComPPI
HCLS1 SNCA 25348397 N/A physical interaction ComPPI
FBXW7 SNCA 25348397 N/A physical interaction ComPPI
RAB8A SNCA 24234451 24983211 25348397 27898060 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
PRKCD SNCA 25348397 N/A physical interaction ComPPI
MAPK3 SNCA 25348397 N/A physical interaction ComPPI
USP7 SNCA 25348397 N/A physical interaction ComPPI
PRKCE SNCA 10407019 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DOCK7 SNCA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIAH1 SNCA 25348397 N/A physical interaction ComPPI
GSK3B SNCA 21985244 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HERC5 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAB SNCA 10407019 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GAPDH SNCA 15673432 21900206 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
TUBG1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYN1 SNCA 22163275 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
RRAS2 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSD SNCA 25348397 N/A physical interaction ComPPI
TUBA1B SNCA 25348397 N/A physical interaction ComPPI
UBC SNCA 25348397 N/A physical interaction ComPPI
HSP90AA1 SNCA 25348397 N/A physical interaction ComPPI
P3H1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SERPINB13 SNCA 25348397 N/A physical interaction ComPPI
CAV1 SNCA 25348397 N/A physical interaction ComPPI
HAX1 SNCA 25348397 N/A physical interaction ComPPI
HSPA1A SNCA 19875982 21985244 24234451 25348397 physical association fluorescence technology,fluorescent resonance energy transfer,nuclear magnetic resonance,pull down,physical interaction,comigration in non denaturing gel electrophoresis ComPPI,IntAct
HSPA1B SNCA 25348397 N/A physical interaction,comigration in non denaturing gel electrophoresis ComPPI
PRDX1 SNCA 25348397 N/A physical interaction ComPPI
GBA SNCA 21653695 23266198 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSAP SNCA 25348397 N/A physical interaction ComPPI
PLK1 SNCA 25348397 N/A physical interaction ComPPI
PELP1 SNCA 25348397 N/A physical interaction ComPPI
MAPT SNCA 10464279 15904919 17408955 21127069 21985244 25348397 27898060 N/A pull down,physical interaction,in vitro,in vivo ComPPI,OmniPath
CSNK2A1 SNCA 10617630 10852916 14525934 19576176 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
EEF1A1 SNCA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ELK1 SNCA 11279280 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VDAC1 SNCA 18614564 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SQSTM1 SNCA 11447312 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MAPK8IP1 SNCA 11790792 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
NOS1AP SNCA 25348397 N/A physical interaction ComPPI
RAB5A SNCA 25348397 N/A physical interaction ComPPI
GRK1 SNCA 25348397 N/A physical interaction ComPPI
GRK6 SNCA 10852916 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRK5 SNCA 10617630 10852916 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
YWHAQ SNCA 25348397 N/A physical interaction ComPPI
CBX4 SNCA 25348397 N/A physical interaction ComPPI
ENC1 SNCA 25348397 N/A physical interaction ComPPI
ARRB1 SNCA 25348397 N/A physical interaction ComPPI
GRK2 SNCA 10617630 10852916 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CLTC SNCA 25348397 N/A physical interaction ComPPI
PRSS1 SNCA 25348397 N/A physical interaction ComPPI
VDAC2 SNCA 18614564 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
NEDD4L SNCA 25348397 N/A physical interaction ComPPI
SRI SNCA 25348397 N/A physical interaction ComPPI
TGM1 SNCA 25348397 N/A physical interaction ComPPI
CSNK2A2 SNCA 10617630 10852916 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AP1B1 SNCA 25348397 N/A physical interaction ComPPI
SPTBN1 SNCA 18614564 22771809 24234451 25348397 27898060 association pull down,physical interaction ComPPI,IntAct,OmniPath
KLC1 SNCA 25348397 N/A physical interaction ComPPI
EGFR SNCA 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
TUBA1A SNCA 11687285 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SEPTIN2 SNCA 25348397 N/A physical interaction ComPPI
YWHAH SNCA 14525934 16096643 24234451 24895406 25348397 27898060 colocalization experimental interaction detection,fluorescence polarization spectroscopy,in vivo,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
YWHAE SNCA 10407019 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HTT SNCA 22119730 24234451 25348397 27898060 colocalization,physical association comigration in non denaturing gel electrophoresis,fluorescence microscopy,bimolecular fluorescence complementation ComPPI,IntAct,OmniPath
FKBP4 SNCA 25348397 N/A physical interaction ComPPI
H3C15 SNCA 16959795 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HSPA4 SNCA 14711827 17010992 17012257 21358815 21832061 21985244 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MEF2D SNCA 25348397 N/A physical interaction ComPPI
MTREX SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPB1 SNCA 25348397 N/A physical interaction ComPPI
USP8 SNCA 25348397 N/A physical interaction ComPPI
MAP1LC3A SNCA 25348397 N/A physical interaction ComPPI
SNCAIP SNCA 10319874 11331421 12044636 14525934 19762560 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,cross-linking study,experimental interaction detection,fluorescence correlation spectroscopy,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
PLK3 SNCA 25348397 N/A physical interaction ComPPI
TH SNCA 11943812 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UQCRC2 SNCA 25348397 N/A physical interaction ComPPI
LAMP2 SNCA 25348397 N/A physical interaction ComPPI
FYN SNCA 11162638 11744621 12096713 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PAK3 SNCA 25348397 N/A physical interaction ComPPI
PRKN SNCA 11588587 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SSB SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDIA2 SNCA 25348397 N/A physical interaction ComPPI
NEDD4 SNCA 25348397 N/A physical interaction ComPPI
FXR1 SNCA 25348397 N/A physical interaction ComPPI
FMR1 SNCA 25348397 N/A physical interaction ComPPI
NUFIP1 SNCA 25348397 N/A physical interaction ComPPI
TAF7 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MT-CO1 SNCA 25348397 N/A physical interaction ComPPI
BAX SNCA 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
DYNC1H1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGS1 SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA KLK6 12928483 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SNCA MT-CO3 12059041 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,in vitro ComPPI,IntAct,OmniPath
SNCA SLC6A3 11292651 12672538 14525934 22163275 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
SNCA MAP1B 10764738 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SNCA SNCB 11683992 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SNCA TOR1A 11438481 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SNCA SEPTIN4 25348397 N/A physical interaction ComPPI
SNCA PLD1 11821392 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SNCA APP 14525934 18769546 21832049 24234451 25241761 25348397 27898060 7568089 9163350 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
SNCA CDC42EP3 25348397 N/A physical interaction ComPPI
SNCA CDC42SE1 25348397 N/A physical interaction ComPPI
SNCA ARHGAP15 25348397 N/A physical interaction ComPPI
SNCA ADAP2 25348397 N/A physical interaction ComPPI
SNCA DMTN 25348397 N/A physical interaction ComPPI
SNCA GABARAPL1 25348397 N/A physical interaction ComPPI
SNCA KIAA1191 25348397 N/A physical interaction ComPPI
SNCA RNF10 25348397 N/A physical interaction ComPPI
SNCA IARS1 25348397 N/A physical interaction ComPPI
SNCA NDUFB6 25348397 N/A physical interaction ComPPI
SNCA LRRK2 23183827 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
SNCA HERPUD1 25348397 N/A physical interaction ComPPI
SNCA APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNCA CDK4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNCA A1BG 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNCA EEF1A1P5 25348397 N/A physical interaction ComPPI
SNCA SDF4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNCA USP9X 25348397 N/A physical interaction ComPPI
SNCA STUB1 25348397 N/A physical interaction ComPPI
SNCA BAG5 25348397 N/A physical interaction ComPPI
SNCA TPPP 17027006 24234451 25348397 colocalization physical interaction,imaging technique ComPPI,IntAct
SNCA PINK1 25348397 N/A physical interaction ComPPI
SNCA SLC6A4 16882008 19429025 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SNCA PLCB2 25348397 N/A physical interaction ComPPI
SNCA SLC6A2 17156375 18331289 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SNCA HSPB6 25348397 N/A physical interaction ComPPI
SNCA HSPB2 25348397 N/A physical interaction ComPPI
SNCA ACTA1 25348397 N/A physical interaction ComPPI
SNCA ENSA 17893145 18973346 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SNCA ANXA6 25348397 N/A physical interaction ComPPI
SNCA BDH2 25348397 N/A physical interaction ComPPI
SNCA HSD17B4 25348397 N/A physical interaction ComPPI
SNCA PFDN2 25348397 N/A physical interaction ComPPI
SNCA USP47 25348397 N/A physical interaction ComPPI
SNCA COA8 25348397 N/A physical interaction ComPPI
SNCA ARPP19 25348397 N/A physical interaction ComPPI
SNCA RALGDS 25348397 N/A physical interaction ComPPI
SNCA DNAJB1 25348397 N/A physical interaction ComPPI
SNCA PARK7 15502874 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA AKT1 21474915 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SNCA CSNK1A1 25348397 N/A physical interaction ComPPI
SNCA DYRK1A 25348397 N/A physical interaction ComPPI
SNCA HSP90AA2P 25348397 N/A physical interaction ComPPI
SNCA TUBB1 25348397 N/A physical interaction ComPPI
SNCA CHMP5 25348397 N/A physical interaction ComPPI
SNCA DGUOK 25348397 N/A physical interaction ComPPI
SNCA DNAAF2 25348397 N/A physical interaction ComPPI
SNCA FSD1 25348397 N/A physical interaction ComPPI
SNCA COL7A1 25348397 N/A physical interaction ComPPI
SNCA DHCR24 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA HSPA1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA ILF3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA NCBP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA POLR2H 25348397 N/A physical interaction ComPPI
SNCA RREB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA SRSF4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA AKAP17A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA EFTUD2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA LCMT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA PATJ 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA CGRRF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA PRDX3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA NCBP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA SNRNP200 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA VIRMA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA PRPF19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA SGSM3 25348397 N/A physical interaction ComPPI
SNCA SRRT 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SNCA PPIL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA SMU1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA ZCCHC8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA CEP295 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA CMBL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNCA NDFIP1 25348397 N/A physical interaction ComPPI
SNCA MAN2C1 25348397 N/A physical interaction ComPPI
SNCA TMPRSS12 25348397 N/A physical interaction ComPPI
SNCA HK1 25348397 N/A physical interaction ComPPI
SNCA PREP 25348397 N/A physical interaction ComPPI
SNCA ATG5 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SNCA WDFY3 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PLK2 SNCA 25348397 N/A physical interaction ComPPI
SRRM1 SNCA 25348397 N/A physical interaction ComPPI
HPRT1 SNCA 25348397 N/A physical interaction ComPPI
SNCA CALM2 12358748 14525934 N/A experimental interaction detection HPRD
SNCA UBB 11603807 14525934 N/A experimental interaction detection HPRD
FGR SNCA 11162638 11744621 12096713 14525934 N/A experimental interaction detection HPRD
COL25A1 SNCA 14525934 15522881 N/A experimental interaction detection HPRD
SNCA SNCA 15502874 16330551 16764865 18614564 19745811 19875982 21443877 22119730 23927048 24234451 24374342 24895406 24983211 25643172 25732184 colocalization,association,physical association biophysical,circular dichroism,classical fluorescence spectroscopy,transmission electron microscopy,cosedimentation,cross-linking study,dynamic light scattering,electron microscopy,fluorescence technology,molecular sieving,nuclear magnetic resonance,pull down,comigration in non denaturing gel electrophoresis,electron tomography,confocal microscopy,comigration in sds page,bimolecular fluorescence complementation,proximity ligation assay,atomic force microscopy,detection by mass spectrometry IntAct
ADRB2 SNCA 24234451 28298427 physical association ubiquitin reconstruction IntAct
CHRM5 SNCA 24234451 28298427 physical association ubiquitin reconstruction IntAct
SNCA DNAJC5 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
SNCA KCNJ11 20858756 27898060 N/A N/A OmniPath
LYN SNCA 11162638 11744621 12096713 27898060 stimulant N/A OmniPath
FYN SNCA 11078745 11162638 11744621 12096713 12893833 15033366 27898060 stimulant N/A OmniPath
CSNK1A1 SNCA 10617630 16959772 27898060 stimulant N/A OmniPath
PLK1 SNCA 10617630 10852916 11813001 12505616 14579119 14645218 15834418 15944382 16847063 16957079 16959772 17296554 17652097 18178617 18238775 18343814 18562315 19004816 19889641 20064389 20356833 21400129 21562258 21849493 21865317 22079575 22315227 22344688 25394490 25637461 27898060 stimulant N/A OmniPath
PLK2 SNCA 19004816 19889641 21849493 22988096 27898060 stimulant N/A OmniPath
SNCA PIN1 16365047 27898060 N/A N/A OmniPath
PIN1 SNCA 16365047 27898060 N/A N/A OmniPath
PLK3 SNCA 19889641 21849493 27898060 stimulant N/A OmniPath
MAPK3 SNCA 12121974 27898060 N/A N/A OmniPath
CSNK1D SNCA 10617630 10852916 16618118 25241761 27898060 N/A N/A OmniPath
MAPK1 SNCA 11279280 12121974 27898060 N/A N/A OmniPath
SNCA MAPK1 11279280 12121974 27898060 stimulant N/A OmniPath
CSNK2A1 SNCA 10617630 10852916 12096713 12893833 15033366 19576176 27898060 stimulant N/A OmniPath
PPP2CA SNCA 21562258 27898060 inhibition N/A OmniPath
PRKN SNCA 11588587 12666095 16714300 18195004 19651786 20418918 25861987 27898060 inhibition,stimulant N/A OmniPath
MAPK8 SNCA 12121974 27898060 N/A N/A OmniPath
ELK1 SNCA 11279280 27898060 N/A N/A OmniPath
FGR SNCA 11162638 11744621 12096713 27898060 stimulant N/A OmniPath
GRK2 SNCA 10617630 10852916 27898060 inhibition N/A OmniPath
SYK SNCA 10617630 11078745 11162638 11744621 11813001 12096713 27898060 inhibition,stimulant N/A OmniPath
DYRK1A SNCA 16959772 27898060 stimulant N/A OmniPath
PTK2B SNCA 11162638 11744621 11821392 12096713 12893833 24412932 27898060 N/A N/A OmniPath
GRK5 SNCA 10617630 10852916 16957079 27898060 inhibition,stimulant N/A OmniPath
CSNK2A2 SNCA 10617630 10852916 27898060 N/A N/A OmniPath
LRRK2 SNCA 19576176 23183827 27898060 stimulant N/A OmniPath
PPP2CB SNCA 21562258 27898060 inhibition N/A OmniPath

Visualization










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