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GENE：SOS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SOS1
FullNmae SOS Ras/Rac guanine nucleotide exchange factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11187
EnsembleID ENSG00000115904
Uniprot Q07889

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SOS1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOS1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOS1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SOS1 GO:0001782,GO:0001942,GO:0002931,GO:0003209,GO:0003344,GO:0005085,GO:0005085,GO:0005085,GO:0005096,GO:0005154,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0006357,GO:0007165,GO:0007173,GO:0007265,GO:0007265,GO:0007296,GO:0007411,GO:0008286,GO:0008543,GO:0017124,GO:0019221,GO:0033081,GO:0035264,GO:0038095,GO:0042127,GO:0042129,GO:0043025,GO:0043547,GO:0045742,GO:0046982,GO:0048009,GO:0048011,GO:0048514,GO:0050853,GO:0050900,GO:0051057,GO:0060021,GO:0061029,GO:0061384,GO:0140693,GO:1904693,GO:1905360,GO:2000973

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SOS1 hsa:6654 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
SOS1 hsa:6654 path:hsa01522 Endocrine resistance - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04510 Focal adhesion - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04540 Gap junction - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04714 Thermogenesis - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
SOS1 hsa:6654 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05034 Alcoholism - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05160 Hepatitis C - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05161 Hepatitis B - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05210 Colorectal cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05213 Endometrial cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05214 Glioma - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05215 Prostate cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05224 Breast cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05226 Gastric cancer - Homo sapiens (human)
SOS1 hsa:6654 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITSN1 SOS1 12970366 23180781 physical association gst pull down InnateDB
SOS1 GRB2 18778683 19323566 20005866 23180781 8647802 9199344 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry InnateDB
SPRY2 SOS1 16339969 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOS1 SPRY3 16339969 23180781 physical association anti tag coimmunoprecipitation InnateDB
GRAP SOS1 16293107 23180781 23331499 8647802 stimulation,physical association pull down InnateDB,SignaLink
PLCG1 SOS1 10026222 10811803 11390650 12471105 17474147 19592646 20484116 23180781 24243840 29145629 8702662 8995445 physical association peptide array,inferred by curator InnateDB,Reactome
CD79B SOS1 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGHD SOS1 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
CD79A SOS1 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGKC SOS1 11071869 11449366 11909947 12456653 19372136 21822214 24243840 29145629 9341187 9697839 9705962 enzymatic reaction,physical association inferred by curator Reactome
SYK SOS1 10026222 11071869 11449366 11909947 12456653 12573241 15184383 19372136 19592646 21659545 21822214 24243840 29145629 7518558 8629002 8630736 8702662 8986718 8995445 9341187 9697839 9705962 enzymatic reaction,physical association inferred by curator Reactome
IGHM SOS1 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
SOS1 SH3KBP1 11071869 12456653 21822214 22262777 29145629 9697839 physical association inferred by curator Reactome
SOS1 BLNK 11071869 12456653 21822214 22262777 29145629 9697839 physical association inferred by curator Reactome
LYN SOS1 24243840 29145629 8400282 9209406 enzymatic reaction,physical association inferred by curator Reactome
SOS1 IRS2 29145629 7739560 8316835 8400282 8530377 8621421 8810325 8816480 9003010 9209406 9832424 9852124 physical association inferred by curator Reactome
IRS1 SOS1 29145629 7739560 8316835 8530377 8621421 8810325 8816480 9003010 9832424 9852124 physical association inferred by curator Reactome
FYN SOS1 12700044 24243840 2809592 29145629 enzymatic reaction,physical association inferred by curator Reactome
NCAM1 SOS1 12700044 2809592 29145629 physical association inferred by curator Reactome
SOS1 SOS1 11560935 1465135 21779497 26467481 29145629 8294403 8493579 9690470 physical association,up-regulates activity,guanine nucleotide exchange factor inferred by curator Reactome,Signor
NCK1 SOS1 24243840 29145629 physical association inferred by curator Reactome
PIK3R1 SOS1 10068651 16456001 21653832 29145629 physical association inferred by curator Reactome
BTK SOS1 12573241 15184383 15365099 21659545 24243840 29145629 7518558 8629002 8630736 8986718 enzymatic reaction,physical association inferred by curator Reactome
VAV1 SOS1 10395673 11007481 11278486 11340169 11804587 12573241 12670394 17540168 24243840 29145629 7518558 8629002 8630736 8673706 8986718 9099726 physical association inferred by curator Reactome
PLCG2 SOS1 10026222 10811803 11390650 12471105 19592646 20484116 24243840 29145629 8702662 8995445 physical association inferred by curator Reactome
HRAS SOS1 10722704 11157491 11429702 12147692 1371879 1377053 15118125 15284455 1569084 16024644 16129412 16483568 1721591 18381441 18757403 19103595 19946327 20179196 21160078 21666749 21711248 24243840 24588013 25467007 29145629 7731718 7970720 8388543 8493579 8530489 8530511 8622888 9038378 9070211 9690470 9739761 9857065 enzymatic reaction inferred by curator Reactome
NRAS SOS1 10722704 11157491 11429702 12147692 1371879 1377053 15118125 15284455 1569084 16024644 16129412 16483568 1721591 18381441 18757403 19103595 19946327 20179196 21160078 21666749 21711248 24243840 24588013 25467007 29145629 7731718 7970720 8388543 8493579 8530489 8530511 8622888 9038378 9070211 9690470 9739761 9857065 enzymatic reaction inferred by curator Reactome
KRAS SOS1 10722704 11157491 11429702 12147692 1371879 1377053 15118125 15284455 1569084 16024644 16129412 16483568 1721591 18381441 18757403 19103595 19946327 20179196 21160078 21666749 21711248 24243840 24588013 25467007 29145629 7731718 7970720 8388543 8493579 8530489 8530511 8622888 9038378 9070211 9690470 9739761 9857065 enzymatic reaction inferred by curator Reactome
MAPK3 SOS1 23331499 29145629 7739560 8816480 9922370 enzymatic reaction,stimulation inferred by curator Reactome,SignaLink
MAPK1 SOS1 23331499 8816480 9922370 stimulation N/A SignaLink
SOS1 HRAS 10913276 23331499 9690470 stimulation N/A SignaLink
SOS1 NRAS 11560935 23331499 stimulation N/A SignaLink
SOS1 KRAS 16293107 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AHR SOS1 20950586 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR SOS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 SOS1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 SOS1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SOS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SOS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A SOS1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
YBX1 SOS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SOS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SOS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC SOS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA SOS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 SOS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A SOS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 SOS1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000183BED SOS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D5FFC SOS1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 SOS1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA SOS1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000024DFCE SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F SOS1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 SOS1 25416803 25469565 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 SOS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPS6KA1 SOS1 22135298 phosphorylation N/A PhosphoSite
HRAS SOS1 25361965 interaction type N/A PTMCode2
SOS1 HRAS 25361965 interaction type N/A PTMCode2
NCK1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 NCK1 25361965 interaction type N/A PTMCode2
NCK2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 NCK2 25361965 interaction type N/A PTMCode2
EPS8 SOS1 25361965 interaction type N/A PTMCode2
SOS1 EPS8 25361965 interaction type N/A PTMCode2
RIT2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 RIT2 25361965 interaction type N/A PTMCode2
SH3PXD2A SOS1 25361965 interaction type N/A PTMCode2
SOS1 SH3PXD2A 25361965 interaction type N/A PTMCode2
SOS1 MAPK1 25361965 interaction type N/A PTMCode2
ABI1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 ABI1 25361965 interaction type N/A PTMCode2
EPS8L1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 EPS8L1 25361965 interaction type N/A PTMCode2
FGFR1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 FGFR1 25361965 interaction type N/A PTMCode2
MET SOS1 25361965 interaction type N/A PTMCode2
SOS1 MET 25361965 interaction type N/A PTMCode2
FYN SOS1 25361965 interaction type N/A PTMCode2
SOS1 FYN 25361965 interaction type N/A PTMCode2
EPS8L2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 EPS8L2 25361965 interaction type N/A PTMCode2
HCK SOS1 25361965 interaction type N/A PTMCode2
SOS1 HCK 25361965 interaction type N/A PTMCode2
SHC2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 SHC2 25361965 interaction type N/A PTMCode2
GAB1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 GAB1 25361965 interaction type N/A PTMCode2
SRC SOS1 25361965 interaction type N/A PTMCode2
SOS1 SRC 25361965 interaction type N/A PTMCode2
SOS1 SHC1 25361965 interaction type N/A PTMCode2
SHC1 SOS1 25361965 interaction type N/A PTMCode2
EGFR SOS1 25361965 interaction type N/A PTMCode2
SOS1 EGFR 25361965 interaction type N/A PTMCode2
RRAS SOS1 25361965 interaction type N/A PTMCode2
SOS1 RRAS 25361965 interaction type N/A PTMCode2
ABL1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 ABL1 25361965 interaction type N/A PTMCode2
GRB2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 GRB2 25361965 interaction type N/A PTMCode2
ERBB3 SOS1 25361965 interaction type N/A PTMCode2
SOS1 ERBB3 25361965 interaction type N/A PTMCode2
CRK SOS1 25361965 interaction type N/A PTMCode2
SOS1 CRK 25361965 interaction type N/A PTMCode2
RANBP9 SOS1 25361965 interaction type N/A PTMCode2
SOS1 RANBP9 25361965 interaction type N/A PTMCode2
CRKL SOS1 25361965 interaction type N/A PTMCode2
SOS1 CRKL 25361965 interaction type N/A PTMCode2
ERBB2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 ERBB2 25361965 interaction type N/A PTMCode2
FRS2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 FRS2 25361965 interaction type N/A PTMCode2
GRAP SOS1 25361965 interaction type N/A PTMCode2
SOS1 GRAP 25361965 interaction type N/A PTMCode2
PIK3R1 SOS1 25361965 interaction type N/A PTMCode2
SOS1 PIK3R1 25361965 interaction type N/A PTMCode2
RET SOS1 25361965 interaction type N/A PTMCode2
SOS1 RET 25361965 interaction type N/A PTMCode2
PIK3R2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 PIK3R2 25361965 interaction type N/A PTMCode2
BCR SOS1 25361965 interaction type N/A PTMCode2
SOS1 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 SOS1 10026169 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3R2 SOS1 14525934 25348397 9651378 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UBASH3A SOS1 25348397 N/A two hybrid ComPPI
SH3KBP1 SOS1 11071869 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PACSIN3 SOS1 14525934 14679214 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
LAT SOS1 25348397 N/A physical interaction ComPPI
GRAP SOS1 14525934 25348397 8647802 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN6 SOS1 14525934 25348397 8632004 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAC1 SOS1 25348397 N/A physical interaction ComPPI
CRK SOS1 14525934 17474147 19380743 24234451 25241761 25348397 8810325 association,physical association experimental interaction detection,peptide array,physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
PACSIN1 SOS1 11352907 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ERBB2 SOS1 11173924 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NF2 SOS1 25348397 N/A physical interaction ComPPI
CBL SOS1 25348397 N/A physical interaction ComPPI
MAPK1 SOS1 14525934 25348397 8816480 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HRAS SOS1 11560935 12628188 14525934 15507210 17084389 18454158 19141281 20133692 24234451 25348397 9447984 9690470 physical association experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,enzymatic study,in vivo,gdp/gtp exchange assay ComPPI,HPRD,IntAct
CD2AP SOS1 14525934 14679214 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
PIK3R1 SOS1 17474147 24234451 25241761 25348397 physical association peptide array,physical interaction,proximity ligation assay ComPPI,IntAct
PTPN11 SOS1 14525934 25348397 9344843 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SRC SOS1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CRKL SOS1 14525934 23397142 24234451 25348397 9162067 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
LCK SOS1 25348397 N/A physical interaction ComPPI
SHC1 SOS1 14525934 19380743 24234451 25348397 7520523 8631299 9544989 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
SOS1 RRAS 11560935 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOS1 ZAP70 14525934 25348397 7629168 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SOS1 NCK1 10026169 10206341 14525934 17474147 24234451 25348397 7862111 8810325 physical association experimental interaction detection,peptide array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 ITSN1 10716926 14525934 15824104 20936779 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 ABI1 10499589 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 ABI3 11956071 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SOS1 FRS2 14525934 25348397 9182757 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOS1 SNX9 14525934 14679214 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 RIT2 12099688 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SOS1 SNX18 14525934 14679214 24234451 25348397 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
SOS1 BIN1 14525934 25348397 9182529 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SOS1 GRB2 12577067 14525934 14679214 16520382 16906159 17474147 19323566 21706016 21988832 24234451 25348397 7527391 7629138 7642581 7773779 8479541 8493579 8810325 8816480 9447984 9569023 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,peptide array,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SOS1 ATP6V1E1 11560919 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SOS1 EPS8L1 14525934 14565974 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SOS1 EPS8L2 25348397 N/A physical interaction,in vitro ComPPI
SOS1 CSF1R 14525934 25348397 7520523 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOS1 CAV1 14525934 15976327 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOS1 CD19 10706702 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOS1 ESR1 14525934 15173068 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SOS1 EPS8 10499589 14525934 16520382 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SOS1 RANBP9 12147692 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SOS1 LAT2 25348397 N/A in vitro ComPPI
SOS1 EGFR 14525934 24234451 25348397 26005835 9447973 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SOS1 FGFR1 24234451 25241761 25348397 physical association physical interaction,in vivo,proximity ligation assay ComPPI,IntAct
SOS1 FYN 14525934 17474147 24234451 25348397 9856337 physical association experimental interaction detection,peptide array,physical interaction,in vitro ComPPI,HPRD,IntAct
SOS1 HCK 12029088 14525934 17141806 23397142 24234451 25348397 physical association classical fluorescence spectroscopy,experimental interaction detection,pull down,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SOS1 BCR 25348397 N/A physical interaction ComPPI
SOS1 ABL1 25348397 N/A physical interaction ComPPI
SOS1 MUC1 11278868 14525934 25348397 7664271 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SOS1 ANXA2P2 25348397 N/A physical interaction ComPPI
SOS1 ANXA2 25348397 N/A physical interaction ComPPI
SOS1 PLCG1 10913276 14525934 17474147 24234451 25348397 9020117 physical association experimental interaction detection,fluorescence technology,peptide array,pull down,physical interaction ComPPI,HPRD,IntAct
SOS1 MET 25348397 N/A physical interaction ComPPI
SOS1 HDLBP 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SOS1 SPTAN1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SOS1 ITSN2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SOS1 SH3BP5 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOS1 TNIK 25348397 N/A physical interaction ComPPI
SOS1 SORBS1 25348397 N/A physical interaction ComPPI
SOS1 TNFRSF1A 25348397 N/A physical interaction ComPPI
SOS1 LRRK1 25348397 N/A physical interaction ComPPI
SOS1 NTRK1 25348397 N/A physical interaction ComPPI
SOS1 NEB 12482578 24234451 25348397 N/A circular dichroism,classical fluorescence spectroscopy,nuclear magnetic resonance ComPPI,IntAct
SOS1 SH3PXD2A 19464300 24234451 25348397 27898060 N/A peptide array,pull down ComPPI,IntAct,OmniPath
SOS1 RET 19914172 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SOS1 NOSTRIN 22751148 24234451 25348397 N/A pull down ComPPI,IntAct
GAB1 SOS1 11707404 14525934 23397142 24234451 25348397 physical association experimental interaction detection,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SRRM1 SOS1 25348397 N/A physical interaction ComPPI
ERBB3 SOS1 11173924 14525934 N/A experimental interaction detection HPRD
SOS1 SOS1 14525934 14656442 N/A experimental interaction detection HPRD
H1-5 SOS1 24234451 30021884 physical association cross-linking study IntAct
SOS1 CNOT9 17023541 27898060 N/A N/A OmniPath
PLCG1 SOS1 10913276 10940929 17474147 27898060 9020117 stimulant N/A OmniPath
SOS1 PLCG1 10913276 10940929 17474147 27898060 9020117 N/A N/A OmniPath
SOS1 HRAS 11560935 12628188 15507210 17084389 18454158 19141281 20133692 23132018 27898060 9447984 9690470 stimulant N/A OmniPath
RPS6KA1 SOS1 22827337 27898060 N/A N/A OmniPath
GRB2 SOS1 10025673 10207103 10319320 10477741 10570290 10716926 11960376 11964172 11997436 12577067 14679214 15746962 16520382 16893902 16906159 17474147 18778683 19323566 19380743 20005866 21706016 21988832 23334917 23452850 27898060 7510700 7514169 7527391 7629138 7629168 7642581 7664271 7773779 8112292 8188688 8479540 8479541 8493579 8647802 8695800 8810325 8816480 8943292 9009162 9199344 9344843 9383403 9447984 9716598 9872323 stimulant N/A OmniPath
MAPK3 SOS1 27898060 7478566 8816480 9922370 inhibition,stimulant N/A OmniPath
ABL1 SOS1 15039778 20841568 27898060 stimulant N/A OmniPath
SHC1 SOS1 10025673 10570290 10675333 10783152 19380743 27898060 7520523 8114695 8631299 8950973 9344843 9544989 stimulant N/A OmniPath
SOS1 NRAS 11560935 21779497 27898060 7923364 8493579 9690470 stimulant N/A OmniPath
MAPK1 SOS1 10197981 12509440 27898060 8816480 992237 inhibition,stimulant N/A OmniPath
SOS1 ITSN1 10716926 12970366 15824104 18539136 20936779 27898060 N/A N/A OmniPath
ITSN1 SOS1 10716926 12970366 15824104 18539136 20936779 27898060 N/A N/A OmniPath
SPRY1 SOS1 11585837 27898060 inhibition N/A OmniPath
SOS1 SPRY2 11585837 16339969 27898060 N/A N/A OmniPath
SOS1 SPRY3 16339969 27898060 N/A N/A OmniPath
SOS1 KRAS 16293107 25624485 27898060 stimulant N/A OmniPath
GRAP SOS1 16293107 27898060 8647802 stimulant N/A OmniPath

Visualization










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