Gene Information gene info

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GENE：SPP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPP1
FullNmae secreted phosphoprotein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11255
EnsembleID ENSG00000118785
Uniprot P10451

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPP1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPP1 GO:0001649,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005788,GO:0005794,GO:0006710,GO:0007155,GO:0007155,GO:0007165,GO:0007566,GO:0031214,GO:0033280,GO:0036005,GO:0036094,GO:0042995,GO:0043167,GO:0043167,GO:0045780,GO:0045893,GO:0046697,GO:0048471,GO:0048545,GO:0048685,GO:0050840,GO:0070062,GO:0071394,GO:2000866

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPP1 hsa:6696 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
SPP1 hsa:6696 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SPP1 hsa:6696 path:hsa04510 Focal adhesion - Homo sapiens (human)
SPP1 hsa:6696 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
SPP1 hsa:6696 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
SPP1 hsa:6696 path:hsa04929 GnRH secretion - Homo sapiens (human)
SPP1 hsa:6696 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CEBPA SPP1 14712233 18971253 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MYB SPP1 18459127 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
PRDM14 SPP1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ERG SPP1 21669963 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 SPP1 21669963 trascriptional regulation,stimulation inferred by curator TFlink
FOXD3 SPP1 11891324 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 SPP1 20609221 22422937 trascriptional regulation,stimulation inferred by curator TFlink
HTATIP2 SPP1 18537194 19349353 trascriptional regulation,stimulation inferred by curator TFlink
ING4 SPP1 17848618 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 SPP1 11126367 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 SPP1 11126367 trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 SPP1 11126367 trascriptional regulation,stimulation inferred by curator TFlink
POU5F1 SPP1 11891324 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SPP1 11126367 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SPP1 11126367 trascriptional regulation,stimulation inferred by curator TFlink
TFCP2 SPP1 20404171 21703197 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
LEF1 SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 SPP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000017DBB8 SPP1 19538464 rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000017DBB8 SPP1 19538464 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 SPP1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EFBE3 SPP1 20110513 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000007340 SPP1 25416803 27126955 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ITGA5 SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGA5 25361965 interaction type N/A PTMCode2
MMP7 SPP1 25361965 interaction type N/A PTMCode2
SPP1 MMP7 25361965 interaction type N/A PTMCode2
MMP3 SPP1 25361965 interaction type N/A PTMCode2
SPP1 MMP3 25361965 interaction type N/A PTMCode2
CSNK2A1 SPP1 25361965 interaction type N/A PTMCode2
SPP1 CSNK2A1 25361965 interaction type N/A PTMCode2
ITGAV SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGAV 25361965 interaction type N/A PTMCode2
F2 SPP1 25361965 interaction type N/A PTMCode2
SPP1 F2 25361965 interaction type N/A PTMCode2
ITGB1 SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGB1 25361965 interaction type N/A PTMCode2
ITGA9 SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGA9 25361965 interaction type N/A PTMCode2
CD44 SPP1 25361965 interaction type N/A PTMCode2
SPP1 CD44 25361965 interaction type N/A PTMCode2
IGFBP5 SPP1 25361965 interaction type N/A PTMCode2
SPP1 IGFBP5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GET3 SPP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTA SPP1 14525934 16189514 21988832 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
SGTB SPP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FTH1 SPP1 25348397 N/A physical interaction ComPPI
TUBB SPP1 25348397 N/A physical interaction ComPPI
MEOX2 SPP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MMP3 SPP1 11375993 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 SPP1 25348397 N/A physical interaction ComPPI
CALM1 SPP1 25348397 N/A physical interaction ComPPI
HBA1 SPP1 25348397 N/A physical interaction ComPPI
MRPL23 SPP1 25348397 N/A physical interaction ComPPI
PRKACB SPP1 25348397 N/A physical interaction ComPPI
CD44 SPP1 10657301 12377945 14525934 20146103 20549562 24234451 25348397 colocalization,physical association experimental interaction detection,fluorescence microscopy,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
MMP7 SPP1 11375993 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCA SPP1 14525934 25348397 8663267 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 SPP1 25348397 N/A protease assay,protein cleavage ComPPI
NACA SPP1 25348397 N/A physical interaction ComPPI
COPS5 SPP1 25348397 N/A physical interaction ComPPI
RBBP6 SPP1 25348397 N/A physical interaction ComPPI
ITGB1 SPP1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
ACP5 SPP1 14525934 25348397 27898060 2808373 8195113 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SPP1 ITGAV 10835423 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SPP1 ITGA9 10593924 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SPP1 F2 11375993 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SPP1 CSNK2A1 14525934 25348397 8663267 N/A experimental interaction detection,in vitro ComPPI,HPRD
SPP1 PDLIM7 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPP1 CTNNBL1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPP1 UBQLN4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
SPP1 ABCF3 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SPP1 ITGA5 25348397 N/A in vitro ComPPI
SPP1 IGFBP5 10698186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPP1 BAG6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SPP1 EIF3K 25348397 N/A physical interaction ComPPI
SPP1 C1RL 25348397 N/A physical interaction ComPPI
SPP1 COMMD1 25348397 N/A physical interaction ComPPI
SPP1 NCSTN 25348397 N/A physical interaction ComPPI
SPP1 USP42 25348397 N/A physical interaction ComPPI
SPP1 CISD2 25348397 N/A physical interaction ComPPI
SPP1 USP8 25348397 N/A physical interaction ComPPI
SPP1 AFF4 25348397 N/A physical interaction ComPPI
SPP1 AMOTL2 25348397 N/A physical interaction ComPPI
SPP1 DCX 25348397 N/A physical interaction ComPPI
SPP1 EEF1A1 25348397 N/A physical interaction ComPPI
SPP1 EEF1A1P5 25348397 N/A physical interaction ComPPI
SPP1 CEP162 25348397 N/A physical interaction ComPPI
SPP1 MAP1A 25348397 N/A physical interaction ComPPI
SPP1 MAP1B 25348397 N/A physical interaction ComPPI
SPP1 MARCKS 25348397 N/A physical interaction ComPPI
SPP1 NCKAP1 25348397 N/A physical interaction ComPPI
SPP1 RANBP9 25348397 N/A physical interaction ComPPI
SPP1 SEC24C 25348397 N/A physical interaction ComPPI
SPP1 STAU1 25348397 N/A physical interaction ComPPI
SPP1 DNAJB1 25348397 N/A physical interaction ComPPI
SPP1 STK39 25348397 N/A physical interaction ComPPI
SPP1 GRIPAP1 25348397 N/A physical interaction ComPPI
SPP1 RAPGEF2 25348397 N/A physical interaction ComPPI
SPP1 TPT1 25348397 N/A physical interaction ComPPI
SPP1 TBC1D8 25348397 N/A physical interaction ComPPI
SPP1 CC2D1B 25348397 N/A physical interaction ComPPI
SPP1 CMTM3 25348397 N/A physical interaction ComPPI
SPP1 RPL5 25348397 N/A physical interaction ComPPI
SPP1 RPL13 25348397 N/A physical interaction ComPPI
SPP1 RPL15 25348397 N/A physical interaction ComPPI
SPP1 RPS13 25348397 N/A physical interaction ComPPI
SPP1 RIMS4 25348397 N/A physical interaction ComPPI
SPP1 SNAPIN 25348397 N/A physical interaction ComPPI
SPP1 ATP2A2 25348397 N/A physical interaction ComPPI
SPP1 CACNG4 25348397 N/A physical interaction ComPPI
SPP1 LRRC4 25348397 N/A physical interaction ComPPI
SPP1 ATP5PB 25348397 N/A physical interaction ComPPI
SPP1 CHD1 25348397 N/A physical interaction ComPPI
SPP1 DNTTIP2 25348397 N/A physical interaction ComPPI
SPP1 EPAS1 25348397 N/A physical interaction ComPPI
SPP1 HMGN1 25348397 N/A physical interaction ComPPI
SPP1 SLC39A6 25348397 N/A physical interaction ComPPI
SPP1 ZNF638 25348397 N/A physical interaction ComPPI
SPP1 BRD3 25348397 N/A physical interaction ComPPI
SPP1 CYB5R3 25348397 N/A physical interaction ComPPI
SPP1 DSEL 25348397 N/A physical interaction ComPPI
SPP1 KCNIP1 25348397 N/A physical interaction ComPPI
SPP1 MPPED1 25348397 N/A physical interaction ComPPI
SPP1 PEMT 25348397 N/A physical interaction ComPPI
SPP1 PLD3 25348397 N/A physical interaction ComPPI
SPP1 NACA 25348397 N/A physical interaction ComPPI
SPP1 NACA4P 25348397 N/A physical interaction ComPPI
SPP1 SSB 25348397 N/A physical interaction ComPPI
SPP1 TMEM168 25348397 N/A physical interaction ComPPI
SPP1 TMEM30A 25348397 N/A physical interaction ComPPI
SPP1 ZNF804A 25348397 N/A physical interaction ComPPI
SPP1 PEPD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SPP1 PARP1 25348397 N/A physical interaction ComPPI
SPP1 TRAF3 25348397 N/A physical interaction ComPPI
SPP1 RSC1A1 25348397 N/A physical interaction ComPPI
SPP1 CASP8 25348397 N/A protease assay,protein cleavage ComPPI
SPP1 NCS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPP1 FAM20C 22582013 24234451 25348397 26091039 phosphorylation reaction,colocalization,physical association fluorescence microscopy,protein kinase assay ComPPI,IntAct
PRKG1 SPP1 14525934 25348397 8663267 N/A experimental interaction detection,in vitro ComPPI,HPRD
APOA1 SPP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CSNK2A2 SPP1 14525934 25348397 8663267 N/A experimental interaction detection,in vitro ComPPI,HPRD
TTC1 SPP1 25348397 N/A physical interaction ComPPI
C2ORF50 SPP1 25348397 N/A physical interaction ComPPI
CCR8 SPP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SPP1 DRD2 24234451 28298427 physical association ubiquitin reconstruction IntAct
PTGER4 SPP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SETD1A SPP1 11687631 11742990 11752412 16787775 16921172 19713935 22158900 23453808 27898060 N/A N/A OmniPath
SPP1 ITGA4 19417209 27898060 stimulant N/A OmniPath
SPP1 S1PR1 27898060 9488656 N/A N/A OmniPath

Visualization










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