Gene Information gene info

  1. Home

GENE：TLR5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR5
FullNmae toll like receptor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11851
EnsembleID ENSG00000187554
Uniprot O60602

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TLR5 GO:0002224,GO:0004888,GO:0005149,GO:0005515,GO:0005886,GO:0006954,GO:0032757,GO:0034146,GO:0038023,GO:0038187,GO:0045087,GO:0071260

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR5 hsa:7100 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR5 hsa:7100 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TLR5 hsa:7100 path:hsa05131 Shigellosis - Homo sapiens (human)
TLR5 hsa:7100 path:hsa05132 Salmonella infection - Homo sapiens (human)
TLR5 hsa:7100 path:hsa05134 Legionellosis - Homo sapiens (human)
TLR5 hsa:7100 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRAK4 TLR5 17138965 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 TLR5 12794153 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TLR5 16482509 16644730 20855887 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
IRAK1 TLR5 11953430 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR5 PIK3R1 16644730 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR5 MYD88 16644730 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKD1 TLR5 17442957 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TLR5 20855887 23180781 physical association anti tag coimmunoprecipitation InnateDB
TP53 TLR5 21483755 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TLR5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 TLR5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TLR5 19559773 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 TLR5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 TLR5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TLR5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F859B TLR5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 TLR5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 TLR5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 TLR5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D TLR5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F TLR5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001CF056 TLR5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000425000 TLR5 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKD1 TLR5 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SIGLEC7 TLR5 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
MAN1A2 TLR5 25348397 N/A physical interaction ComPPI
TLR4 TLR5 12794153 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MYD88 TLR5 14525934 16482509 17583698 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SIGIRR TLR5 12925853 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTRH2 TLR5 25348397 N/A physical interaction ComPPI
RNF216 TLR5 14525934 15107846 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TLR1 TLR5 12600829 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLR5 DHRS3 25348397 N/A physical interaction ComPPI
TLR5 CNPY3 25348397 N/A physical interaction ComPPI
TLR5 ACOT12 25348397 N/A physical interaction ComPPI
TLR5 SNX14 25348397 N/A physical interaction ComPPI
TLR5 PRXL2A 25348397 N/A physical interaction ComPPI
TLR5 DHRS7 25348397 N/A physical interaction ComPPI
TLR5 DDRGK1 25348397 N/A physical interaction ComPPI
TLR5 TMX2 25348397 N/A physical interaction ComPPI
TLR5 CTDNEP1 25348397 N/A physical interaction ComPPI
TLR5 SIGLEC9 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
SIGLEC5 TLR5 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR5 TLR5 23155421 24234451 physical association tox-r dimerization assay IntAct
TLR5 PRKD1 17442957 27898060 N/A N/A OmniPath
PRKD1 TLR5 17442957 20557879 27898060 stimulant N/A OmniPath
TLR5 TICAM1 20855887 27898060 N/A N/A OmniPath
TLR4 TLR5 12794153 27898060 N/A N/A OmniPath
TLR5 MYD88 16410796 16482509 16644730 17583698 20855887 27898060 stimulant N/A OmniPath
MYD88 TLR5 16482509 16644730 17583698 20855887 27898060 N/A N/A OmniPath
IRAK1 TLR5 11953430 27898060 N/A N/A OmniPath
IRAK4 TLR5 17138965 27898060 N/A N/A OmniPath
ZG16B TLR5 20802527 27898060 N/A N/A OmniPath

Visualization










  Return