GENE：TLR8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TLR8 |
| FullNmae | toll like receptor 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:15632 |
| EnsembleID | ENSG00000101916 |
| Uniprot | Q9NR97 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TLR8 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TLR8 | autophagy | 26115100 | RNA interference for ATG13, TFEB, TLR8, or BECN1 inhibits this HIV-induced autophagy. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TLR8 | GO:0000139,GO:0001932,GO:0002224,GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005789,GO:0005886,GO:0006954,GO:0007249,GO:0007249,GO:0009615,GO:0009897,GO:0010008,GO:0016064,GO:0032695,GO:0032727,GO:0032728,GO:0032729,GO:0032731,GO:0032755,GO:0032755,GO:0032757,GO:0034158,GO:0036020,GO:0038023,GO:0038187,GO:0045087,GO:0045089,GO:0051607,GO:0051607,GO:0051607,GO:0051607,GO:0071260 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TLR8 | hsa:51311 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| TLR8 | hsa:51311 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| TLR8 | hsa:51311 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYD88 | TLR8 | 16482509 23180781 | physical association | two hybrid | InnateDB |
| TLR8 | BTK | 12724322 17932028 23180781 | physical association | anti tag coimmunoprecipitation,two hybrid | InnateDB |
| TLR7 | TLR8 | 17040905 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | TLR9 | 17040905 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | CEBPD | 20829351 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | CEBPB | 20829351 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | STAT1 | 20829351 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | CD14 | 21078886 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TP53 | TLR8 | 21483755 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TLR8 | UNC93B1 | 22164301 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TP53 | TLR8 | 15843459 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TLR8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BTK | TLR8 | 12724322 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| SIGLEC10 | TLR8 | 24234451 25187624 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| MYD88 | TLR8 | 14525934 16482509 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| SIGLEC5 | TLR8 | 24234451 25187624 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| TLR8 | UNC93B1 | 22164301 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct |
| TLR8 | SIGLEC9 | 24234451 25187624 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| TLR8 | TLR8 | 23155421 24234451 | physical association | tox-r dimerization assay | IntAct |
| MYD88 | TLR8 | 16482509 27898060 | N/A | N/A | OmniPath |
| TLR8 | MYD88 | 16482509 19775907 27898060 | stimulant | N/A | OmniPath |
| BTK | TLR8 | 12724322 17932028 27898060 | N/A | N/A | OmniPath |
| TLR8 | TLR9 | 17040905 27898060 | N/A | N/A | OmniPath |
| CD14 | TLR8 | 21078886 27898060 | N/A | N/A | OmniPath |
| TLR8 | TLR7 | 17040905 27898060 | inhibition | N/A | OmniPath |
| UNC93B1 | TLR8 | 22164301 27898060 | N/A | N/A | OmniPath |