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GENE：TPI1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPI1
FullNmae triosephosphate isomerase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12009
EnsembleID ENSG00000111669
Uniprot P60174

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPI1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPI1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration

Go Annotation:

GeneSymbol Go id
TPI1 GO:0004807,GO:0004807,GO:0004807,GO:0004807,GO:0005515,GO:0005615,GO:0005634,GO:0005829,GO:0005829,GO:0006094,GO:0006094,GO:0006096,GO:0008929,GO:0019242,GO:0019563,GO:0031625,GO:0042803,GO:0046166,GO:0046166,GO:0061621,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPI1 hsa:7167 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
TPI1 hsa:7167 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
TPI1 hsa:7167 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
TPI1 hsa:7167 path:hsa01100 Metabolic pathways - Homo sapiens (human)
TPI1 hsa:7167 path:hsa01200 Carbon metabolism - Homo sapiens (human)
TPI1 hsa:7167 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EZH2 TPI1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 TPI1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 TPI1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 TPI1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SP1 TPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TPI1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171CD1 TPI1 18362358 rna interference,inhibition experimental interaction detection miRSponge
URS0000171CD1 TPI1 18362358 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003D5391 TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000040EE1D TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001F0C23 TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065D58 TPI1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000209F04 TPI1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075B0F6 TPI1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032BDF4 TPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000096022 TPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 TPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 TPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 TPI1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000821E0 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D1FC TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003B59DF TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C5969 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000105D19 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000003575B TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000054A671 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B0E50 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AAA0 TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045147B TPI1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EXOSC5 TPI1 25348397 N/A physical interaction ComPPI
LDHB TPI1 25348397 N/A physical interaction ComPPI
LDHA TPI1 25348397 N/A physical interaction ComPPI
PCNA TPI1 20849852 24234451 25348397 physical association far western blotting,physical interaction ComPPI,IntAct
CFL1 TPI1 12359716 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
KEAP1 TPI1 25348397 N/A physical interaction ComPPI
MCM2 TPI1 25348397 N/A physical interaction ComPPI
EZH2 TPI1 25348397 N/A physical interaction ComPPI
SP1 TPI1 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
SETDB1 TPI1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DSTN TPI1 25348397 N/A physical interaction ComPPI
LIG4 TPI1 25348397 N/A physical interaction ComPPI
PSMA3 TPI1 25348397 N/A physical interaction ComPPI
U2AF2 TPI1 25348397 N/A physical interaction ComPPI
GAPDH TPI1 25348397 N/A physical interaction ComPPI
YWHAZ TPI1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
CDKN2A TPI1 25348397 N/A two hybrid ComPPI
PDIA6 TPI1 25348397 N/A physical interaction ComPPI
UBA52 TPI1 25348397 N/A physical interaction ComPPI
PGM1 TPI1 25348397 N/A physical interaction ComPPI
NTRK1 TPI1 25348397 N/A physical interaction ComPPI
ENO1 TPI1 25348397 N/A physical interaction ComPPI
STIP1 TPI1 25348397 N/A physical interaction ComPPI
VCL TPI1 25348397 N/A physical interaction ComPPI
CFTR TPI1 25348397 N/A physical interaction ComPPI
MAPK6 TPI1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VDAC1 TPI1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EWSR1 TPI1 25348397 N/A physical interaction ComPPI
AKR1B1 TPI1 25348397 N/A physical interaction ComPPI
YWHAQ TPI1 25348397 N/A physical interaction ComPPI
TPI1 DDX24 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TPI1 LIPT1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TPI1 CCL11 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TPI1 EGFR 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
TPI1 UCHL5 25348397 N/A physical interaction ComPPI
TPI1 HDAC5 25348397 N/A physical interaction ComPPI
TPI1 TERF1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TPI1 POT1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TPI1 CDK2 25348397 N/A physical interaction ComPPI
TPI1 CUL1 25348397 N/A physical interaction ComPPI
TPI1 APP 25348397 N/A physical interaction ComPPI
TPI1 TKT 25348397 N/A physical interaction ComPPI
TPI1 PGK1 25348397 N/A physical interaction ComPPI
TPI1 GPI 25348397 N/A physical interaction ComPPI
TPI1 PRDX6 25348397 N/A physical interaction ComPPI
TPI1 SEC23IP 25348397 N/A physical interaction ComPPI
TPI1 SSU72 25348397 N/A physical interaction ComPPI
TPI1 MPST 25348397 N/A physical interaction ComPPI
TPI1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPI1 TARDBP 25348397 N/A physical interaction ComPPI
TPI1 CUL7 25348397 N/A physical interaction ComPPI
TPI1 OBSL1 25348397 N/A physical interaction ComPPI
TPI1 CCDC8 25348397 N/A physical interaction ComPPI
TPI1 SUZ12 25348397 N/A physical interaction ComPPI
TPI1 RNF2 25348397 N/A physical interaction ComPPI
TPI1 ANP32E 25348397 N/A physical interaction ComPPI
TPI1 CRIP1 25348397 N/A physical interaction ComPPI
TPI1 HNRNPR 25348397 N/A physical interaction ComPPI
TPI1 NDUFV1 25348397 N/A physical interaction ComPPI
TPI1 PGM2 25348397 N/A physical interaction ComPPI
TPI1 PGM2L1 25348397 N/A physical interaction ComPPI
TPI1 ADSL 25348397 N/A physical interaction ComPPI
TPI1 ALDH6A1 25348397 N/A physical interaction ComPPI
TPI1 C11ORF54 25348397 N/A physical interaction ComPPI
TPI1 DHRS11 25348397 N/A physical interaction ComPPI
TPI1 ENO2 25348397 N/A physical interaction ComPPI
TPI1 ENO3 25348397 N/A physical interaction ComPPI
TPI1 GOT1 25348397 N/A physical interaction ComPPI
TPI1 GPD1L 25348397 N/A physical interaction ComPPI
TPI1 LDHAL6A 25348397 N/A physical interaction ComPPI
TPI1 LDHAL6B 25348397 N/A physical interaction ComPPI
TPI1 LDHC 25348397 N/A physical interaction ComPPI
TPI1 NDUFV2 25348397 N/A physical interaction ComPPI
TPI1 NIT2 25348397 N/A physical interaction ComPPI
TPI1 OXCT1 25348397 N/A physical interaction ComPPI
TPI1 PDCD6IP 25348397 N/A physical interaction ComPPI
TPI1 PDXK 25348397 N/A physical interaction ComPPI
TPI1 PGAM1 25348397 N/A physical interaction ComPPI
TPI1 PRDX2 25348397 N/A physical interaction ComPPI
TPI1 SERPINB3 25348397 N/A physical interaction ComPPI
TPI1 SERPINB5 25348397 N/A physical interaction ComPPI
TPI1 SOD2 25348397 N/A physical interaction ComPPI
TPI1 SORD 25348397 N/A physical interaction ComPPI
TPI1 UQCRFS1 25348397 N/A physical interaction ComPPI
TPI1 MED20 25348397 N/A physical interaction ComPPI
TPI1 GOLT1B 25348397 N/A physical interaction ComPPI
TPI1 NANOGP8 25348397 N/A physical interaction ComPPI
TPI1 NANOG 25348397 N/A physical interaction ComPPI
TPI1 HYPK 25348397 N/A physical interaction ComPPI
TPI1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPI1 TRIM25 25348397 N/A physical interaction ComPPI
TPI1 BRCA1 25348397 N/A physical interaction ComPPI
TPI1 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TPI1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
ASS1 TPI1 25348397 N/A physical interaction ComPPI
ATF2 TPI1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNPEP TPI1 25348397 N/A physical interaction ComPPI
RIDA TPI1 25348397 N/A physical interaction ComPPI
ESD TPI1 25348397 N/A physical interaction ComPPI
TPI1 TPI1 14525934 8061610 N/A experimental interaction detection HPRD
SMARCB1 TPI1 24234451 30108113 association proximity-dependent biotin identification IntAct
HTR2C TPI1 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 TPI1 24234451 28298427 physical association ubiquitin reconstruction IntAct
DAG1 TPI1 24234451 association cross-linking study IntAct
CASP1 TPI1 17959595 27898060 inhibition N/A OmniPath

Visualization










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