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GENE：TRPV4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRPV4
FullNmae transient receptor potential cation channel subfamily V member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18083
EnsembleID ENSG00000111199
Uniprot Q9HBA0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRPV4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TRPV4 GO:0000122,GO:0001666,GO:0002024,GO:0003779,GO:0005034,GO:0005080,GO:0005261,GO:0005262,GO:0005262,GO:0005262,GO:0005515,GO:0005516,GO:0005524,GO:0005783,GO:0005881,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0005929,GO:0005929,GO:0006816,GO:0006816,GO:0006874,GO:0006884,GO:0007015,GO:0007015,GO:0007043,GO:0007204,GO:0007231,GO:0007231,GO:0007231,GO:0008017,GO:0008289,GO:0009612,GO:0009986,GO:0010759,GO:0010977,GO:0015275,GO:0016020,GO:0016324,GO:0019901,GO:0030027,GO:0030036,GO:0030103,GO:0030175,GO:0030426,GO:0030864,GO:0031117,GO:0032587,GO:0032755,GO:0032868,GO:0034605,GO:0042169,GO:0042538,GO:0042593,GO:0042802,GO:0043014,GO:0043117,GO:0043622,GO:0045989,GO:0046330,GO:0046785,GO:0046872,GO:0047484,GO:0048487,GO:0050729,GO:0050891,GO:0051015,GO:0060351,GO:0070374,GO:0070509,GO:0070588,GO:0070588,GO:0071470,GO:0071476,GO:0071476,GO:0071477,GO:0071639,GO:0071642,GO:0071651,GO:0097497,GO:0098703,GO:1902656,GO:1903444,GO:1903715,GO:2000340

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRPV4 hsa:59341 path:hsa04218 Cellular senescence - Homo sapiens (human)
TRPV4 hsa:59341 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
TRPV4 hsa:59341 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRPV4 RXRA 20926124 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRPV4 VDR 20926124 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TRPV4 LCK 20005715 interaction type N/A PSP
TRPV4 FYN 20005715 interaction type N/A PSP
TRPV4 LYN 20005715 interaction type N/A PSP
TRPV4 SRC 20005715 interaction type N/A PSP
TRPV4 SRC 12538589 18988627 20005715 N/A N/A SignaLink
TRPV4 FYN 12538589 18988627 20005715 20005715 N/A N/A SignaLink
TRPV4 LCK 12538589 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CEBPA TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TRPV4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 TRPV4 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD TRPV4 22135298 phosphorylation N/A PhosphoSite
PRKACA TRPV4 22135298 phosphorylation N/A PhosphoSite
TRPV4 ITCH 25361965 interaction type N/A PTMCode2
ITCH TRPV4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 TRPV4 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PACSIN3 TRPV4 14525934 16627472 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
RAN TRPV4 24234451 24855949 25348397 physical association pull down ComPPI,IntAct
PACSIN1 TRPV4 14525934 16627472 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TRPV4 LYN 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRPV4 SRC 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRPV4 MAP7 14517216 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TRPV4 PACSIN2 14525934 16627472 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TRPV4 ITCH 14525934 17110928 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRPV4 OS9 14525934 17932042 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TRPV4 FYN 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRPV4 HCK 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRPV4 LCK 12538589 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRPV4 KRIT1 25348397 N/A physical interaction ComPPI
TRPV4 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRPV4 AKAP5 25348397 N/A physical interaction ComPPI
TRPV4 CANX 16293632 24234451 25348397 27898060 colocalization confocal microscopy ComPPI,IntAct,OmniPath
TRPV4 HIF1AN 21251231 24234451 25348397 hydroxylation reaction enzymatic study ComPPI,IntAct
TRPV4 CALM2 12724311 14525934 N/A experimental interaction detection HPRD
TRPV4 TRPV4 14525934 16293632 24234451 26146187 physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer HPRD,IntAct
AQP4 TRPV4 21262839 27898060 N/A N/A OmniPath
ACTB TRPV4 19027987 27898060 N/A N/A OmniPath
AQP5 TRPV4 16571723 27898060 N/A N/A OmniPath
ITPR3 TRPV4 18378772 18826956 27898060 stimulant N/A OmniPath
OS9 TRPV4 17932042 27898060 inhibition N/A OmniPath
SRC TRPV4 12538589 19033444 27898060 stimulant N/A OmniPath
PKD2 TRPV4 18695040 20682256 22518003 23977387 25114176 27898060 stimulant N/A OmniPath
TRPV4 PKD2 18695040 20682256 22518003 23977387 25114176 27898060 stimulant N/A OmniPath
YES1 TRPV4 12538589 27898060 stimulant N/A OmniPath
PRKACA TRPV4 25972993 26289129 27898060 stimulant N/A OmniPath
LCK TRPV4 12538589 27898060 stimulant N/A OmniPath
LYN TRPV4 12538589 18234883 19661060 27898060 stimulant N/A OmniPath
AKAP5 TRPV4 24778429 25005230 27898060 stimulant N/A OmniPath
FYN TRPV4 12538589 27898060 stimulant N/A OmniPath
TRPC1 TRPV4 20093626 20705915 21871867 25114176 27898060 stimulant N/A OmniPath
TRPV4 TRPC1 20093626 20705915 21871867 25114176 27898060 stimulant N/A OmniPath
HCK TRPV4 12538589 27898060 stimulant N/A OmniPath
PACSIN3 TRPV4 16627472 18174177 27898060 stimulant N/A OmniPath
ITCH TRPV4 17110928 20650893 27898060 inhibition,stimulant N/A OmniPath
MAP7 TRPV4 14517216 27898060 stimulant N/A OmniPath
PRKCD TRPV4 19661060 27898060 N/A N/A OmniPath

Visualization










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