Gene Information gene info

  1. Home

GENE：UBE3A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE3A
FullNmae ubiquitin protein ligase E3A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12496
EnsembleID ENSG00000114062
Uniprot Q05086

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE3A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UBE3A GO:0000209,GO:0000502,GO:0001541,GO:0003713,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006508,GO:0006511,GO:0007420,GO:0030521,GO:0031398,GO:0032570,GO:0035037,GO:0042752,GO:0043161,GO:0045944,GO:0046872,GO:0048167,GO:0048511,GO:0050847,GO:0051865,GO:0060736,GO:0061630,GO:0061630,GO:0061630,GO:0070936,GO:0098978,GO:1904262,GO:1905528,GO:2000058,GO:2000058

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE3A hsa:7337 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
UBE3A hsa:7337 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
UBE3A hsa:7337 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR UBE3A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 UBE3A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 UBE3A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 UBE3A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 UBE3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 UBE3A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 UBE3A 20215506 21572407 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000285DCB UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 UBE3A 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2E1 UBE3A 25361965 interaction type N/A PTMCode2
UBE3A UBE2E1 25361965 interaction type N/A PTMCode2
UBE2L3 UBE3A 25361965 interaction type N/A PTMCode2
UBE3A UBE2L3 25361965 interaction type N/A PTMCode2
TP53 UBE3A 25361965 interaction type N/A PTMCode2
UBE3A TP53 25361965 interaction type N/A PTMCode2
SCRIB UBE3A 25361965 interaction type N/A PTMCode2
UBE3A SCRIB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KLHL38 UBE3A 25348397 N/A physical interaction ComPPI
KRT6B UBE3A 25348397 N/A physical interaction ComPPI
TCF19 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSPA8 UBE3A 25348397 N/A physical interaction ComPPI
KRT5 UBE3A 25348397 N/A physical interaction ComPPI
ARHGEF15 UBE3A 25348397 N/A physical interaction ComPPI
ANXA1 UBE3A 25348397 N/A physical interaction ComPPI
RARA UBE3A 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,biochemical,two hybrid ComPPI,HPRD,IntAct
PSMC3 UBE3A 25348397 N/A physical interaction ComPPI
POLE4 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAGEA1 UBE3A 25348397 N/A physical interaction ComPPI
WBP2 UBE3A 25348397 N/A physical interaction ComPPI
MAGEA8 UBE3A 25348397 N/A physical interaction ComPPI
CDKN1B UBE3A 25348397 N/A physical interaction ComPPI
MEOX2 UBE3A 25348397 N/A physical interaction ComPPI
PSMD14 UBE3A 25348397 N/A physical interaction ComPPI
ACTB UBE3A 25348397 N/A physical interaction ComPPI
YWHAG UBE3A 25348397 N/A physical interaction ComPPI
CALM1 UBE3A 25348397 N/A physical interaction ComPPI
LSM1 UBE3A 25348397 N/A physical interaction ComPPI
AHSP UBE3A 25348397 N/A physical interaction ComPPI
DR1 UBE3A 25348397 N/A physical interaction ComPPI
UBE2D1 UBE3A 10066826 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MCM6 UBE3A 24234451 25348397 29426014 colocalization confocal microscopy ComPPI,IntAct
CELA2B UBE3A 25348397 N/A physical interaction ComPPI
HBA1 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AB1 UBE3A 25348397 N/A physical interaction ComPPI
SCAMP1 UBE3A 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
HPCAL4 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FAM167A UBE3A 25348397 N/A physical interaction ComPPI
ARHGDIB UBE3A 25348397 N/A physical interaction ComPPI
LCK UBE3A 25348397 N/A physical interaction ComPPI
RPH3A UBE3A 25348397 N/A physical interaction ComPPI
AR UBE3A 14525934 25348397 9891052 N/A experimental interaction detection,physical interaction,biochemical,two hybrid ComPPI,HPRD
NCOA3 UBE3A 25348397 N/A physical interaction ComPPI
EIF4G1 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLK UBE3A 10449731 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UBE2D2 UBE3A 25348397 N/A physical interaction ComPPI
UBE2L3 UBE3A 10558980 14525934 24234451 25348397 8576257 N/A experimental interaction detection,fluorescence polarization spectroscopy,x-ray crystallography,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKACA UBE3A 25348397 N/A physical interaction ComPPI
SPINK1 UBE3A 25348397 N/A physical interaction ComPPI
GSK3B UBE3A 25348397 N/A physical interaction ComPPI
PDIA3 UBE3A 25348397 N/A physical interaction ComPPI
YWHAZ UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDIA6 UBE3A 25348397 N/A physical interaction ComPPI
UBB UBE3A 25348397 N/A physical interaction,physical interaction,comigration in sds page ComPPI
UBC UBE3A 23439649 25348397 27898060 9575161 N/A physical interaction,comigration in sds page ComPPI,OmniPath
RPS27A UBE3A 25348397 N/A physical interaction,comigration in sds page ComPPI
UBA52 UBE3A 25348397 N/A physical interaction,comigration in sds page ComPPI
P3H1 UBE3A 25348397 N/A physical interaction ComPPI
NTRK1 UBE3A 25348397 N/A physical interaction ComPPI
PHKG1 UBE3A 25348397 N/A physical interaction ComPPI
PHKG2 UBE3A 25348397 N/A physical interaction ComPPI
PLAUR UBE3A 25348397 N/A physical interaction ComPPI
CALR UBE3A 25348397 N/A physical interaction ComPPI
KRT7 UBE3A 25348397 N/A physical interaction ComPPI
HSPA5 UBE3A 25348397 N/A physical interaction ComPPI
E2F1 UBE3A 25348397 N/A physical interaction ComPPI
PRDX1 UBE3A 25348397 N/A physical interaction ComPPI
PSAP UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PARVA UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XRCC6 UBE3A 25348397 N/A physical interaction ComPPI
NELFCD UBE3A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DBNL UBE3A 25348397 N/A physical interaction ComPPI
CFTR UBE3A 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK6 UBE3A 24234451 25348397 26972000 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3C UBE3A 24234451 25348397 29426014 colocalization confocal microscopy ComPPI,IntAct
TSC2 UBE3A 25348397 N/A physical interaction ComPPI
PHKA2 UBE3A 25348397 N/A physical interaction ComPPI
EID1 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UNC45A UBE3A 25348397 N/A physical interaction ComPPI
UBQLN2 UBE3A 10983987 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RAD23A UBE3A 25348397 N/A physical interaction ComPPI
IPO11 UBE3A 25348397 N/A physical interaction ComPPI
SUMO3 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DLG1 UBE3A 25348397 N/A physical interaction ComPPI
MDM2 UBE3A 25348397 N/A physical interaction ComPPI
YWHAE UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA2 UBE3A 25348397 N/A physical interaction ComPPI
HSPA4 UBE3A 25348397 N/A physical interaction ComPPI
RNF2 UBE3A 25348397 N/A physical interaction ComPPI
CEBPZ UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYCBP2 UBE3A 25348397 N/A physical interaction ComPPI
CTNNB1 UBE3A 25348397 N/A physical interaction ComPPI
COPS6 UBE3A 25348397 N/A physical interaction ComPPI
ACTR3 UBE3A 25348397 N/A physical interaction ComPPI
BAK1 UBE3A 24234451 25348397 27898060 9881696 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
HIF1AN UBE3A 25348397 N/A physical interaction ComPPI
JADE1 UBE3A 14525934 16713569 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
RAD23B UBE3A 25348397 N/A physical interaction ComPPI
NR3C1 UBE3A 25348397 N/A physical interaction,biochemical ComPPI
LPP UBE3A 25348397 N/A physical interaction ComPPI
PSMD4 UBE3A 24234451 25348397 29426014 physical association molecular sieving,physical interaction ComPPI,IntAct
ARPC1B UBE3A 25348397 N/A physical interaction ComPPI
UBE2D3 UBE3A 14525934 25348397 9990509 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SRSF9 UBE3A 25348397 N/A physical interaction ComPPI
BPY2 UBE3A 12207887 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
BARD1 UBE3A 25348397 N/A physical interaction ComPPI
SEM1 UBE3A 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARNTL UBE3A 24728990 25348397 25660546 27898060 N/A physical interaction ComPPI,OmniPath
LSM5 UBE3A 25348397 N/A physical interaction ComPPI
UBE2L6 UBE3A 10558980 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
GOLGA3 UBE3A 25348397 N/A physical interaction ComPPI
UBQLN1 UBE3A 25348397 N/A physical interaction ComPPI
TNPO3 UBE3A 25348397 N/A physical interaction ComPPI
PSMC1 UBE3A 25348397 N/A physical interaction ComPPI
ESR1 UBE3A 16314411 22865929 25348397 27898060 9891052 N/A physical interaction,biochemical ComPPI,OmniPath
ESR2 UBE3A 17962381 25348397 25408199 27898060 N/A physical interaction ComPPI,OmniPath
BRCA1 UBE3A 25348397 N/A physical interaction ComPPI
LRSAM1 UBE3A 25348397 N/A physical interaction ComPPI
UBE2E1 UBE3A 14525934 25348397 8576257 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PGR UBE3A 14525934 25348397 9891052 N/A two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
METTL1 UBE3A 25348397 N/A physical interaction ComPPI
PML UBE3A 25348397 N/A physical interaction ComPPI
SMARCC2 UBE3A 25348397 N/A physical interaction ComPPI
ARNTL2 UBE3A 25348397 N/A physical interaction ComPPI
KRT1 UBE3A 25348397 N/A physical interaction ComPPI
TALDO1 UBE3A 25348397 N/A physical interaction ComPPI
ASPM UBE3A 21633703 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SOD1 UBE3A 25348397 N/A physical interaction ComPPI
COPS7B UBE3A 25348397 N/A physical interaction ComPPI
UBE2V1 UBE3A 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
SENP3 UBE3A 25348397 N/A physical interaction ComPPI
MNT UBE3A 25348397 26506232 27898060 N/A physical interaction ComPPI,OmniPath
AFTPH UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FAF2 UBE3A 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CEBPA UBE3A 23598402 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HSF1 UBE3A 25348397 N/A physical interaction ComPPI
SF3B3 UBE3A 25348397 N/A physical interaction ComPPI
GTF3C1 UBE3A 25348397 N/A physical interaction ComPPI
NPLOC4 UBE3A 25348397 N/A physical interaction ComPPI
UFD1 UBE3A 25348397 N/A physical interaction ComPPI
SCRIB UBE3A 11027293 16482544 24234451 25348397 27898060 ubiquitination reaction pull down,physical interaction ComPPI,IntAct,OmniPath
NDUFA13 UBE3A 21765936 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UCHL5 UBE3A 25348397 N/A physical interaction ComPPI
GFAP UBE3A 25348397 N/A physical interaction ComPPI
MCM7 UBE3A 14525934 25348397 9852095 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MYH9 UBE3A 25348397 N/A physical interaction ComPPI
SHBG UBE3A 14525934 15862967 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
ACTA2 UBE3A 25348397 N/A physical interaction ComPPI
ACTA1 UBE3A 25348397 N/A physical interaction ComPPI
ADRM1 UBE3A 25348397 N/A physical interaction ComPPI
RPS15A UBE3A 25348397 N/A physical interaction ComPPI
TRPV5 UBE3A 25348397 N/A physical interaction ComPPI
DDX39B UBE3A 25348397 N/A physical interaction ComPPI
ARC UBE3A 25348397 N/A physical interaction ComPPI
PHKB UBE3A 25348397 N/A physical interaction ComPPI
C11ORF49 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FUZ UBE3A 25348397 N/A physical interaction ComPPI
EAPP UBE3A 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
UBXN1 UBE3A 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXNL1 UBE3A 25348397 N/A physical interaction ComPPI
SACS UBE3A 25348397 N/A physical interaction ComPPI
WDCP UBE3A 25348397 N/A physical interaction ComPPI
ATG9A UBE3A 25348397 N/A physical interaction ComPPI
SRPRB UBE3A 25348397 N/A physical interaction ComPPI
NEURL4 UBE3A 24234451 25348397 29426014 association molecular sieving,physical interaction ComPPI,IntAct
NSUN2 UBE3A 25348397 N/A physical interaction ComPPI
ASAP3 UBE3A 25348397 N/A physical interaction ComPPI
KDELR1 UBE3A 25348397 N/A physical interaction ComPPI
KRT9 UBE3A 25348397 N/A physical interaction ComPPI
HERC2 UBE3A 21493713 22645313 24234451 25348397 25476789 27898060 29426014 colocalization physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
TTC3 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APP UBE3A 25348397 N/A physical interaction ComPPI
TP53 UBE3A 12620801 14525934 16493710 24234451 25348397 26789255 9143503 9369221 association,physical association experimental interaction detection,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
UBE3A ANXA2P2 25348397 N/A physical interaction ComPPI
UBE3A PSMD3 25348397 N/A physical interaction ComPPI
UBE3A NOMO2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A PDE1B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A PRAG1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A RMI1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A TRIM65 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A TBC1D14 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE3A HERC2P3 25348397 N/A physical interaction ComPPI
UBE3A USP14 25348397 N/A physical interaction ComPPI
UBE3A PTPN3 25348397 N/A physical interaction ComPPI
UBE3A BTF3L4 25348397 N/A physical interaction ComPPI
UBE3A SEM1 25348397 N/A physical interaction ComPPI
UBE3A MDM1 25348397 N/A physical interaction ComPPI
UBE3A ACTBL2 25348397 N/A physical interaction ComPPI
UBE3A ZNF746 25348397 N/A physical interaction ComPPI
UBE3A MAP7D2 25348397 N/A physical interaction ComPPI
UBE3A SERHL2 25348397 N/A physical interaction ComPPI
TAT UBE3A 24234451 25348397 25910212 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
YOD1 UBE3A 25348397 N/A physical interaction ComPPI
UBE3A UBE2G1 10558980 14525934 N/A experimental interaction detection HPRD
UBE2G2 UBE3A 10558980 14525934 N/A experimental interaction detection HPRD
UBE3A UBE3A 10558980 12620801 14525934 24234451 association experimental interaction detection,pull down HPRD,IntAct
PRKACA UBE3A 26255772 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS000075A2F5 UBE3A 11562346 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return