GENE：WNT11
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNT11 |
| FullNmae | Wnt family member 11 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12776 |
| EnsembleID | ENSG00000085741 |
| Uniprot | O96014 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNT11 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNT11 | GO:0001649,GO:0001837,GO:0003138,GO:0003139,GO:0003151,GO:0003283,GO:0003402,GO:0005096,GO:0005109,GO:0005109,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0006468,GO:0007165,GO:0007223,GO:0010463,GO:0030182,GO:0030182,GO:0030282,GO:0030295,GO:0030308,GO:0030325,GO:0030336,GO:0031012,GO:0031667,GO:0032915,GO:0034394,GO:0043547,GO:0045165,GO:0045199,GO:0045892,GO:0045893,GO:0048341,GO:0048570,GO:0048706,GO:0048844,GO:0051496,GO:0060028,GO:0060070,GO:0060071,GO:0060197,GO:0060412,GO:0060484,GO:0060675,GO:0060775,GO:0061037,GO:0061053,GO:0061101,GO:0062009,GO:0070830,GO:0071260,GO:0071300,GO:0072089,GO:0072177,GO:0072201,GO:0090037,GO:0090082,GO:0090090,GO:0090272,GO:1904019,GO:1904037,GO:2000647 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WNT11 | hsa:7481 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| WNT11 | hsa:7481 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | WNT11 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | WNT11 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | WNT11 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | WNT11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ERG | WNT11 | 21242973 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KCNH2 | WNT11 | 21242973 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRTAP5-9 | WNT11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | WNT11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-7 | WNT11 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| WNT11 | MDFI | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| WNT11 | KRTAP10-9 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| WNT11 | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT11 | PLA2G10 | 25348397 | N/A | physical interaction | ComPPI |
| WNT11 | WNT16 | 25348397 | N/A | physical interaction | ComPPI |
| WNT11 | WIF1 | 22986341 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| WNT11 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP1-5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP9-3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP1-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP5-7 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP12-3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP5-8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | RASSF10 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | CCNDBP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | KRTAP17-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | FUCA2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| WNT11 | LRP6 | 15578921 27898060 | stimulant | N/A | OmniPath |
| WNT11 | FZD3 | 15578921 16273260 27898060 | stimulant | N/A | OmniPath |
| WNT11 | FZD7 | 10862746 27898060 | stimulant | N/A | OmniPath |
| WNT11 | FZD6 | 16273260 27898060 | stimulant | N/A | OmniPath |
| MUSK | WNT11 | 22309736 23151663 27898060 | stimulant | N/A | OmniPath |
| WNT11 | MUSK | 22309736 23151663 27898060 | stimulant | N/A | OmniPath |