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GENE：RUNX3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RUNX3
FullNmae RUNX family transcription factor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10473
EnsembleID ENSG00000020633
Uniprot Q13761

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RUNX3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RUNX3 GO:0000122,GO:0000785,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001222,GO:0001503,GO:0002062,GO:0003700,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005829,GO:0006355,GO:0006357,GO:0006468,GO:0016513,GO:0030097,GO:0030182,GO:0043231,GO:0043371,GO:0043378,GO:0045595,GO:0045786,GO:0045893,GO:0048935,GO:0050680,GO:0071559,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RUNX3 hsa:864 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
RUNX3 hsa:864 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SRC RUNX3 20100835 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
RUNX3 FYN 20100835 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUNX3 LCK 20100835 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUNX3 KIR2DL3 15778373 23180781 physical association electrophoretic mobility supershift assay InnateDB
KIR2DL4 RUNX3 15778373 23180781 physical association electrophoretic mobility supershift assay InnateDB
RUNX3 KIR2DL4 22467658 23180781 physical association electrophoretic mobility supershift assay InnateDB
RUNX3 KIR3DL1 22467658 23180781 physical association electrophoretic mobility supershift assay InnateDB
TBX21 RUNX3 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 RUNX3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
EZH2 RUNX3 18430739 20631058 22222375 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RUNX3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RUNX3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RUNX3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RUNX3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CBFB RUNX3 24648201 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 RUNX3 22274925 trascriptional regulation,stimulation inferred by curator TFlink
EHMT2 RUNX3 18850007 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 RUNX3 18430739 18850007 22274925 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 RUNX3 22846564 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00002C0FCB RUNX3 20176475 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS00001C11BC RUNX3 23338485 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004B4B85 RUNX3 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004B4B85 RUNX3 19336521 25416803 26515139 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C0FCB RUNX3 20176475 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr TarBase
URS0000315338 RUNX3 22846564 23874686 25416803 26134263 26375442 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C11BC RUNX3 23338485 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000521626 RUNX3 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 RUNX3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00003BBF48 RUNX3 23549984 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000039E1E1 RUNX3 20371350 23932924 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000600E6 RUNX3 20371350 23912048 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000235862 RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F RUNX3 20371350 25416803 27748919 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00002075FA RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B2B RUNX3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003D5391 RUNX3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000419B5A RUNX3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE RUNX3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 RUNX3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005A8ED RUNX3 25416803 26375442 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000ED600 RUNX3 25416803 26170936 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000033B548 RUNX3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AURKA RUNX3 22135298 phosphorylation N/A PhosphoSite
CDK4 RUNX3 22135298 phosphorylation N/A PhosphoSite
PAK1 RUNX3 22135298 phosphorylation N/A PhosphoSite
AURKB RUNX3 22135298 phosphorylation N/A PhosphoSite
PIM1 RUNX3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 RUNX3 25348397 N/A physical interaction ComPPI
CCND1 RUNX3 24229708 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SMURF2 RUNX3 25348397 N/A physical interaction,in vivo ComPPI
TLE1 RUNX3 24234451 25348397 9751710 physical association beta galactosidase complementation,two hybrid,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
SMAD1 RUNX3 25348397 N/A physical interaction ComPPI
EZH2 RUNX3 25348397 N/A physical interaction ComPPI
NOTCH1 RUNX3 25348397 N/A physical interaction ComPPI
SMAD2 RUNX3 25348397 N/A physical interaction ComPPI
EP300 RUNX3 24229708 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
SMAD3 RUNX3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SMAD5 RUNX3 25348397 N/A physical interaction ComPPI
HDAC4 RUNX3 24229708 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,in vitro,in vivo ComPPI,IntAct
TCF7L2 RUNX3 18772112 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
FANCD2 RUNX3 25348397 N/A physical interaction ComPPI
SUV39H1 RUNX3 25348397 N/A physical interaction ComPPI
MDM2 RUNX3 25348397 N/A physical interaction ComPPI
HDAC2 RUNX3 25348397 N/A in vitro,in vivo ComPPI
PHB2 RUNX3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YAP1 RUNX3 25348397 N/A physical interaction ComPPI
BRD2 RUNX3 24229708 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
CTNNB1 RUNX3 18772112 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
SIRT2 RUNX3 25348397 N/A physical interaction ComPPI
HDAC5 RUNX3 24229708 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
RUNX3 SMURF1 25348397 N/A physical interaction,in vivo ComPPI
RUNX3 CBFB 25348397 N/A physical interaction,in vitro ComPPI
RUNX3 SP110 25348397 N/A physical interaction ComPPI
RUNX3 RBPJ 25348397 N/A physical interaction ComPPI
RUNX3 PML 25348397 N/A physical interaction ComPPI
RUNX3 HDAC1 25348397 N/A physical interaction ComPPI
RUNX3 NANOGP8 25348397 N/A physical interaction ComPPI
RUNX3 NANOG 25348397 N/A physical interaction ComPPI
RUNX3 FANCI 25348397 N/A physical interaction ComPPI
RUNX3 MYCN 25348397 N/A physical interaction ComPPI
RUNX3 TCF7 18772112 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
GRO RUNX3 24234451 9751710 physical association two hybrid IntAct
SRC RUNX3 20100835 27898060 N/A N/A OmniPath
PIM1 RUNX3 18767071 27898060 N/A N/A OmniPath
CDK4 RUNX3 19351720 27898060 inhibition N/A OmniPath
EP300 RUNX3 15138260 24229708 27898060 N/A N/A OmniPath
RUNX3 NOTCH1 19800882 27898060 inhibition N/A OmniPath
RUNX3 CD4 17641686 27898060 stimulant N/A OmniPath

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