GENE：SOX17
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SOX17 |
| FullNmae | SRY-box transcription factor 17 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18122 |
| EnsembleID | ENSG00000164736 |
| Uniprot | Q9H6I2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SOX17 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SOX17 | GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001525,GO:0001525,GO:0001570,GO:0001570,GO:0001656,GO:0001706,GO:0001714,GO:0001828,GO:0001947,GO:0003142,GO:0003143,GO:0003151,GO:0003308,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0007283,GO:0007493,GO:0007507,GO:0008013,GO:0009653,GO:0010467,GO:0010628,GO:0016055,GO:0021903,GO:0023019,GO:0030308,GO:0031648,GO:0035050,GO:0042074,GO:0045732,GO:0045893,GO:0045944,GO:0045944,GO:0045995,GO:0048617,GO:0048866,GO:0050821,GO:0060214,GO:0060913,GO:0060914,GO:0060956,GO:0061009,GO:0061010,GO:0061031,GO:0061629,GO:0072091,GO:0072189,GO:0090090,GO:1903226,GO:1990830,GO:2000035,GO:2000043,GO:2000738 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SOX17 | hsa:64321 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | SOX17 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | SOX17 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SOX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SOX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SOX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SOX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SOX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SOX17 | 24449834 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001067D1 | SOX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B7450 | SOX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004C5774 | SOX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | SOX17 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024B619 | SOX17 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042E8CC | SOX17 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | SOX17 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | SOX17 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008DA94 | SOX17 | 19536157 25416803 26277621 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS000016C318 | SOX17 | 25416803 26277621 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HOMER3 | SOX17 | 25348397 | N/A | physical interaction | ComPPI |
| CTNNB1 | SOX17 | 14525934 15163629 17875931 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,IntAct |
| SOX17 | RPL38 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SOX17 | EEFSEC | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SOX17 | APBA3 | 24234451 25348397 26948053 | physical association | two hybrid | ComPPI,IntAct |
| EBNA1BP2 | SOX17 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| POU5F1 | SOX17 | 19736317 24234451 | association | chromatin immunoprecipitation assay | IntAct |
| SOX17 | EZH2 | 24234451 27728805 | association | chromatin immunoprecipitation assay | IntAct |
| SOX17 | CTNNB1 | 10549281 15163629 17875931 27898060 | inhibition | N/A | OmniPath |
| SOX17 | TCF7L2 | 17875931 27898060 | inhibition | N/A | OmniPath |