GENE：TNFSF8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TNFSF8 |
| FullNmae | TNF superfamily member 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11938 |
| EnsembleID | ENSG00000106952 |
| Uniprot | P32971 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TNFSF8 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TNFSF8 | GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0007165,GO:0007267,GO:0042129,GO:0043374,GO:0045944,GO:0050830 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TNFSF8 | hsa:944 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TNFSF8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | TNFSF8 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | TNFSF8 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TNFSF8 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | TNFSF8 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | TNFSF8 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | TNFSF8 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TNFSF8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003CCBB9 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042B108 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B0D1E | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000016914 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170D8B | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000100748 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A608 | TNFSF8 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL9 | TNFSF8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SEMA4C | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| HBA1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| OCLN | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| ATR | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| F5 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN2 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRS | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| ARRB2 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| TNFSF9 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| EFNB3 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| CDON | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| ULBP1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| ULBP3 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| TNFRSF8 | TNFSF8 | 25348397 | N/A | physical interaction,physical interaction,biochemical,in vitro | ComPPI |
| FGFRL1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| TNFSF8 | RYK | 25348397 | N/A | physical interaction | ComPPI |
| TNFSF8 | ULBP2 | 25348397 | N/A | physical interaction | ComPPI |
| TNFSF8 | TNFRSF8 | 10768840 11754357 27898060 8391931 | stimulant | N/A | OmniPath |