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GENE：SSTR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SSTR2
FullNmae somatostatin receptor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11331
EnsembleID ENSG00000180616
Uniprot P30874

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SSTR2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SSTR2 GO:0004994,GO:0005515,GO:0005829,GO:0005886,GO:0007187,GO:0007193,GO:0007218,GO:0007283,GO:0008285,GO:0021549,GO:0030165,GO:0030432,GO:0030900,GO:0038170,GO:0042594,GO:0042923,GO:0043005,GO:0071385,GO:0071392

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SSTR2 hsa:6752 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
SSTR2 hsa:6752 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
SSTR2 hsa:6752 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
SSTR2 hsa:6752 path:hsa04971 Gastric acid secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIK3R1 SSTR2 20005715 interaction type N/A PSP,SignaLink
SHANK2 SSTR2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
E2F4 SSTR2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SSTR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SSTR2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SSTR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SSTR2 14695784 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000451A1 SSTR2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 SSTR2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 SSTR2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00006DE17B SSTR2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B2B5C SSTR2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC SSTR2 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003003B4 SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 SSTR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 SSTR2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B59A2 SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000F31F4 SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000486E0B SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000020579D SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E226A SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000913AC SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000047A67D SSTR2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GRK3 SSTR2 22135298 phosphorylation N/A PhosphoSite
GNAI1 SSTR2 25361965 interaction type N/A PTMCode2
SSTR2 GNAI1 25361965 interaction type N/A PTMCode2
SSTR2 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 SSTR2 25361965 interaction type N/A PTMCode2
SHANK1 SSTR2 25361965 interaction type N/A PTMCode2
SSTR2 SHANK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNA14 SSTR2 11264236 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PTPN6 SSTR2 11920268 14525934 25348397 27898060 9305905 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PIK3R1 SSTR2 14525934 16917505 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
SSTR2 CORT 25348397 N/A physical interaction,in vivo ComPPI
SSTR2 SST 1346068 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SSTR2 SHANK1 10551867 11087996 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SSTR2 GNAI1 14525934 25348397 7914078 N/A experimental interaction detection,in vivo ComPPI,HPRD
SSTR2 ELAVL1 25348397 N/A physical interaction ComPPI
SSTR2 APP 25348397 N/A physical interaction ComPPI
SSTR2 SSTR3 22651821 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,fluorescence microscopy ComPPI,IntAct,OmniPath
SSTR2 SHANK2 10373412 11087996 14525934 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
SSTR2 GNAI3 1374909 27898060 stimulant N/A OmniPath
CORT SSTR2 10598788 15333679 27898060 9125122 9650799 stimulant N/A OmniPath
SSTR2 SH3KBP1 27898060 9305905 stimulant N/A OmniPath
SSTR2 GNAO1 1374909 27898060 stimulant N/A OmniPath
SST SSTR2 1346068 27898060 8702767 stimulant N/A OmniPath
GRK3 SSTR2 21343287 22538189 23418396 24565897 24637622 25012983 27898060 N/A N/A OmniPath

Visualization










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