GENE：LRIG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LRIG1 |
| FullNmae | leucine rich repeats and immunoglobulin like domains 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17360 |
| EnsembleID | ENSG00000144749 |
| Uniprot | Q96JA1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LRIG1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LRIG1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LRIG1 | GO:0005515,GO:0005615,GO:0005886,GO:0007605,GO:0022405,GO:0031012,GO:0032474,GO:0060384 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FOXA1 | LRIG1 | 23180781 25127374 | physical association | anti tag coimmunoprecipitation | InnateDB |
| LRIG1 | CBL | 15282549 23331499 | stimulation | N/A | SignaLink,SignaLink |
| EGFR | LRIG1 | 15282549 15345710 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| LRIG1 | ERBB3 | 16123311 23331499 | stimulation | N/A | SignaLink,SignaLink |
| LRIG1 | ERBB2 | 16123311 23331499 | stimulation | N/A | SignaLink,SignaLink |
| LRIG1 | ERBB4 | 16123311 23331499 | stimulation | N/A | SignaLink,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LRIG1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | LRIG1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | LRIG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | LRIG1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | LRIG1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | LRIG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | LRIG1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000F31F4 | LRIG1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | LRIG1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000122ED0 | LRIG1 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001C770D | LRIG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | LRIG1 | 22995917 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00003AA845 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006B702 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F0130 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000034979B | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004214BB | LRIG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CBL | LRIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| LRIG1 | CBL | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB3 | LRIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| LRIG1 | ERBB3 | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB2 | LRIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| LRIG1 | ERBB2 | 25361965 | interaction type | N/A | PTMCode2 |
| LRIG1 | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | LRIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| LRIG1 | ERBB4 | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB4 | LRIG1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAB4A | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| VCP | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB2 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| CBL | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB4 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| HGS | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| MET | LRIG1 | 17178829 24828152 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| EGFR | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| USP8 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-E | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| GAL3ST1 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| SCGB2A2 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| SCRIB | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| CNPY4 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-DRA | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| PON2 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRK | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB3 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| LRRC40 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | SCARA3 | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | LRIG3 | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | CNPY3 | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | MTFR1L | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | LRIG2 | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | GML | 25348397 | N/A | physical interaction | ComPPI |
| LRIG1 | TUBB8 | 25348397 | N/A | physical interaction | ComPPI |
| CANT1 | LRIG1 | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | LRIG1 | 15282549 1534571 15345710 18542056 27898060 | stimulant | N/A | OmniPath |
| LRIG1 | EGFR | 15282549 15345710 18542056 27898060 | inhibition | N/A | OmniPath |
| LRIG1 | ERBB2 | 16123311 27898060 | inhibition,stimulant | N/A | OmniPath |
| CBL | LRIG1 | 15282549 27898060 | inhibition | N/A | OmniPath |
| LRIG1 | CBL | 15282549 27898060 | stimulant | N/A | OmniPath |
| LRIG1 | ERBB4 | 15282549 15345710 16123311 27898060 | inhibition,stimulant | N/A | OmniPath |
| LRIG1 | ERBB3 | 16123311 27898060 | inhibition,stimulant | N/A | OmniPath |
| LRIG1 | CBLC | 15282549 27898060 | stimulant | N/A | OmniPath |
| CBLC | LRIG1 | 15282549 27898060 | inhibition | N/A | OmniPath |