GENE：NOTCH4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NOTCH4 |
| FullNmae | notch receptor 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7884 |
| EnsembleID | ENSG00000204301 |
| Uniprot | Q99466 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NOTCH4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NOTCH4 | GO:0000122,GO:0000139,GO:0001569,GO:0001709,GO:0001763,GO:0001837,GO:0001944,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0007221,GO:0009986,GO:0030097,GO:0030154,GO:0030879,GO:0038023,GO:0042060,GO:0045596,GO:0045602,GO:0045893,GO:0060354,GO:2000048 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NOTCH4 | hsa:4855 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| NOTCH4 | hsa:4855 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD2 | NOTCH4 | 16007227 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMAD3 | NOTCH4 | 16007227 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMAD4 | NOTCH4 | 16007227 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| DLL4 | NOTCH4 | 10837027 12814948 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| LTC4S | NOTCH4 | 11101851 23331499 | stimulation | N/A | SignaLink |
| MAML2 | NOTCH4 | 12370315 23331499 | stimulation | N/A | SignaLink |
| MAML3 | NOTCH4 | 12370315 23331499 | stimulation | N/A | SignaLink |
| FBXW7 | NOTCH4 | 11585921 14672936 23331499 | inhibition | N/A | SignaLink |
| NOTCH4 | RBPJ | 14701863 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | NOTCH4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | NOTCH4 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | NOTCH4 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NOTCH4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | NOTCH4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | NOTCH4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARG | NOTCH4 | 20436223 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000018C928 | NOTCH4 | 20080834 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00002C7B2B | NOTCH4 | 22074923 | rna interference,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS000018C928 | NOTCH4 | 20080834 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00002C7B2B | NOTCH4 | 22074923 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000035CC3E | NOTCH4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMAD4 | NOTCH4 | 14525934 16007227 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| DLL4 | NOTCH4 | 12814948 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NOTCH4 | MAML1 | 11101851 11585921 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| NOTCH4 | FBXW7 | 11585921 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | SMAD3 | 14525934 16007227 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| NOTCH4 | SMAD2 | 14525934 16007227 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| NOTCH4 | PSEN1 | 11518718 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | RBPJ | 11518718 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | PSEN2 | 11518718 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | MAML2 | 12370315 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | MAML3 | 12370315 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOTCH4 | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH4 | MDM2 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH4 | ELOC | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH4 | EGFL7 | 25348397 | N/A | physical interaction | ComPPI |
| NOTCH4 | NOTCH4 | 12814948 14525934 | N/A | experimental interaction detection | HPRD |
| MDM2 | NOTCH4 | 21402876 27898060 | inhibition | N/A | OmniPath |
| FBXW7 | NOTCH4 | 11585921 1467294 27898060 | inhibition | N/A | OmniPath |
| MAML1 | NOTCH4 | 11101851 11585921 27898060 | stimulant | N/A | OmniPath |
| NOTCH4 | RBPJ | 11518718 14701863 27898060 | stimulant | N/A | OmniPath |
| JAG1 | NOTCH4 | 24563863 27898060 | inhibition | N/A | OmniPath |
| DLL4 | NOTCH4 | 10837027 12814948 1281495 16219802 27898060 | stimulant | N/A | OmniPath |
| ELOC | NOTCH4 | 22001063 27898060 | inhibition | N/A | OmniPath |
| MAML3 | NOTCH4 | 12370315 27898060 | stimulant | N/A | OmniPath |
| NOTCH4 | MAML3 | 12370315 27898060 | stimulant | N/A | OmniPath |
| MAML2 | NOTCH4 | 12370315 27898060 | stimulant | N/A | OmniPath |
| NOTCH4 | MAML2 | 12370315 12386158 27898060 | stimulant | N/A | OmniPath |