GENE：TGFA
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TGFA |
| FullNmae | transforming growth factor alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11765 |
| EnsembleID | ENSG00000163235 |
| Uniprot | P01135 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TGFA | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TGFA | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TGFA | GO:0001525,GO:0005154,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005789,GO:0005886,GO:0007173,GO:0007173,GO:0008083,GO:0008083,GO:0008284,GO:0009986,GO:0012507,GO:0016323,GO:0030297,GO:0030669,GO:0031410,GO:0033116,GO:0035556,GO:0038134,GO:0043410,GO:0045840,GO:0045840,GO:0048018,GO:0048471,GO:0050679,GO:0050731,GO:0051781,GO:0060749,GO:0072574 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TGFA | hsa:7039 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05214 | Glioma - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| TGFA | hsa:7039 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFA | EGFR | 10209155 12297049 20430953 23331499 26192618 | interaction type,stimulation | N/A | ACSN,SignaLink |
| TGFA | SNTA1 | 15123239 23180781 | physical association | peptide array | InnateDB |
| TGFA | TGFA | 14967450 16585207 26467481 | bind,up-regulates activity | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | TGFA | 10828826 11517191 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| ETS1 | TGFA | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | TGFA | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | TGFA | 10828826 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| TP73 | TGFA | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | TGFA | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TGFA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | TGFA | 11556855 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR2 | TGFA | 11517191 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | TGFA | 10828826 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PGR | TGFA | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | TGFA | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000000C73C | TGFA | 23460133 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS000000C73C | TGFA | 23460133 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001B9F58 | TGFA | 23631646 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00001DE669 | TGFA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | TGFA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | TGFA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | TGFA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AF45F | TGFA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000153377 | TGFA | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006A1CB | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001ADE63 | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035CC3E | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005481D | TGFA | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000017EA6A | TGFA | 25416803 26832151 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001496AE | TGFA | 25416803 26843615 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GORASP2 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | GORASP2 | 25361965 | interaction type | N/A | PTMCode2 |
| IDE | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | IDE | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | NKD2 | 25361965 | interaction type | N/A | PTMCode2 |
| NKD2 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | MAGI3 | 25361965 | interaction type | N/A | PTMCode2 |
| MAGI3 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | ADAM17 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM17 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | ERBB4 | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB4 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| RHBDF1 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | RHBDF1 | 25361965 | interaction type | N/A | PTMCode2 |
| SDCBP | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | SDCBP | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB2 | TGFA | 25361965 | interaction type | N/A | PTMCode2 |
| TGFA | ERBB2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SGTA | TGFA | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ERBB2 | TGFA | 10918572 14525934 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| ERBB4 | TGFA | 10918572 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ELANE | TGFA | 14525934 15245434 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| MAGI3 | TGFA | 14525934 15652357 24234451 25348397 | N/A | two hybrid,experimental interaction detection,pull down,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| GORASP2 | TGFA | 11101516 11739402 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| SDCBP | TGFA | 10230395 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| DLG1 | TGFA | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | TGFA | 12297049 14525934 24234451 24658140 25348397 | physical association | biophysical,experimental interaction detection,ubiquitin reconstruction,x-ray crystallography,physical interaction,biochemical,in vitro | ComPPI,HPRD,IntAct |
| ADAM17 | TGFA | 11823465 14525934 24234451 25241761 25348397 27898060 | physical association | experimental interaction detection,physical interaction,in vitro,proximity ligation assay | ComPPI,HPRD,IntAct,OmniPath |
| SNTA1 | TGFA | 10230395 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| MAGI2 | TGFA | 14525934 15652357 24234451 25348397 | N/A | two hybrid,experimental interaction detection,pull down,in vitro,two hybrid | ComPPI,HPRD,IntAct |
| GORASP1 | TGFA | 11739402 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
| ELAVL1 | TGFA | 25348397 | N/A | physical interaction | ComPPI |
| ADAM10 | TGFA | 12590602 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| TGFA | RHBDF1 | 14525934 15965977 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| TGFA | NKD2 | 14525934 15064403 18757723 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| TGFA | TGFA | 12297049 14525934 16107719 | N/A | experimental interaction detection | HPRD |
| SRC | TGFA | 17251915 27898060 | stimulant | N/A | OmniPath |
| TGFA | EGFR | 1020916 12297049 12648464 16585207 17145710 24658140 25402006 27898060 | stimulant | N/A | OmniPath |
| TP53 | TGFA | 18431400 27898060 | stimulant | N/A | OmniPath |