Gene Information gene info

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GENE：TPM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPM1
FullNmae tropomyosin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12010
EnsembleID ENSG00000140416
Uniprot P09493

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPM1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPM1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TPM1 GO:0001725,GO:0003065,GO:0003779,GO:0005200,GO:0005515,GO:0005829,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0006937,GO:0007010,GO:0007015,GO:0008016,GO:0008092,GO:0008307,GO:0008360,GO:0015629,GO:0030017,GO:0030049,GO:0030336,GO:0031529,GO:0032059,GO:0032587,GO:0032781,GO:0034614,GO:0042060,GO:0042802,GO:0042803,GO:0045214,GO:0045785,GO:0046982,GO:0051015,GO:0051015,GO:0051496,GO:0055010,GO:0060048,GO:0060048,GO:1904706,GO:1904753

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPM1 hsa:7168 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
TPM1 hsa:7168 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
TPM1 hsa:7168 path:hsa04814 Motor proteins - Homo sapiens (human)
TPM1 hsa:7168 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
TPM1 hsa:7168 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TPM1 hsa:7168 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TPM1 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR TPM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 TPM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 TPM1 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 TPM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TPM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D TPM1 N/A 17363372 18270520 19253296 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D TPM1 17363372 18270520 18591254 18927107 19253296 19342589 19509158 21817107 22743998 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS00000EED18 TPM1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004AC389 TPM1 22766763 25416803 mrna cleavage,inhibition western blot TarBase
URS000007D64A TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 TPM1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DAPK1 TPM1 22135298 phosphorylation N/A PhosphoSite
PIK3CA TPM1 22135298 phosphorylation N/A PhosphoSite
TMOD1 TPM1 25361965 interaction type N/A PTMCode2
TPM1 TMOD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 TPM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
C1ORF216 TPM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFPT TPM1 25348397 N/A physical interaction ComPPI
PPP1CB TPM1 25348397 N/A physical interaction ComPPI
COX5A TPM1 25348397 N/A physical interaction ComPPI
TNNI1 TPM1 25348397 N/A physical interaction ComPPI
CAGE1 TPM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KXD1 TPM1 16189514 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZYX TPM1 25348397 N/A physical interaction ComPPI
SP1 TPM1 25348397 N/A physical interaction ComPPI
GRB2 TPM1 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN TPM1 14525934 1631061 24234451 25348397 25609649 association anti bait coimmunoprecipitation,experimental interaction detection,two hybrid ComPPI,HPRD,IntAct
TPM2 TPM1 14525934 22939629 24234451 25348397 26186194 27898060 30021884 3857586 7568216 physical association cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct,OmniPath
SF3B1 TPM1 25348397 N/A physical interaction ComPPI
JUND TPM1 25348397 N/A physical interaction ComPPI
FLNA TPM1 25348397 N/A physical interaction ComPPI
ACTN4 TPM1 25348397 N/A physical interaction ComPPI
YWHAZ TPM1 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
DLD TPM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN1 TPM1 25348397 N/A physical interaction ComPPI
HSP90B1 TPM1 25348397 N/A physical interaction ComPPI
CD247 TPM1 24234451 24502978 25348397 association pull down ComPPI,IntAct
IQGAP1 TPM1 25348397 N/A physical interaction ComPPI
CFTR TPM1 25348397 N/A physical interaction ComPPI
PDLIM7 TPM1 25348397 N/A physical interaction ComPPI
TNNT2 TPM1 14525934 25348397 27898060 6746613 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
CNN1 TPM1 25348397 N/A physical interaction ComPPI
VDAC1 TPM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN2 TPM1 25348397 N/A physical interaction ComPPI
TPM3 TPM1 25348397 N/A physical interaction ComPPI
MYO18A TPM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOC4 TPM1 25348397 N/A physical interaction ComPPI
RUFY2 TPM1 25348397 N/A physical interaction ComPPI
DNAJC7 TPM1 25348397 N/A physical interaction ComPPI
YWHAQ TPM1 25348397 N/A physical interaction ComPPI
THOC1 TPM1 25348397 N/A physical interaction ComPPI
HOMER1 TPM1 25348397 N/A physical interaction ComPPI
SNAPIN TPM1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SPTBN1 TPM1 25348397 N/A physical interaction ComPPI
CDK2 TPM1 25348397 N/A physical interaction ComPPI
EGFR TPM1 25348397 N/A physical interaction ComPPI
ABI2 TPM1 25348397 N/A physical interaction ComPPI
SPAG9 TPM1 25348397 N/A physical interaction ComPPI
TNNT1 TPM1 14525934 21516116 24234451 25348397 25416956 27898060 3611073 6822572 8987992 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
MDC1 TPM1 25348397 N/A physical interaction ComPPI
RIPK3 TPM1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAST2 TPM1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DNM1L TPM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRKN TPM1 25348397 N/A physical interaction ComPPI
H3C1 TPM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC37 TPM1 25348397 N/A physical interaction ComPPI
GOLGA3 TPM1 25348397 N/A physical interaction ComPPI
ELAVL1 TPM1 25348397 N/A physical interaction ComPPI
CROCC TPM1 25348397 N/A physical interaction ComPPI
BRCA1 TPM1 25348397 N/A physical interaction ComPPI
STUB1 TPM1 25348397 N/A physical interaction ComPPI
MYOC TPM1 25348397 N/A physical interaction ComPPI
MYH1 TPM1 25348397 N/A physical interaction ComPPI
PARK7 TPM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPP4R2 TPM1 25348397 N/A physical interaction ComPPI
SYNPO TPM1 25348397 N/A physical interaction ComPPI
MAD1L1 TPM1 24234451 25348397 25416956 26871637 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TPM4 TPM1 25348397 N/A physical interaction ComPPI
ANLN TPM1 25348397 N/A physical interaction ComPPI
DLG5 TPM1 25348397 N/A physical interaction ComPPI
PAN2 TPM1 25348397 N/A physical interaction ComPPI
ATF2 TPM1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TES TPM1 25348397 N/A physical interaction ComPPI
SEC23A TPM1 25348397 N/A physical interaction ComPPI
MYH4 TPM1 25348397 N/A physical interaction ComPPI
SF3B2 TPM1 25348397 N/A physical interaction ComPPI
SHTN1 TPM1 25348397 N/A physical interaction ComPPI
MYH9 TPM1 25348397 N/A physical interaction ComPPI
DLST TPM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RBPJ TPM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTA2 TPM1 25348397 N/A physical interaction ComPPI
SORD TPM1 25348397 N/A physical interaction ComPPI
APOH TPM1 19805618 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
CKB TPM1 25348397 N/A physical interaction ComPPI
APPL2 TPM1 25348397 N/A physical interaction ComPPI
AP5Z1 TPM1 25348397 N/A physical interaction ComPPI
PPP6R3 TPM1 25348397 N/A physical interaction ComPPI
LRCH3 TPM1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 TPM1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NEB TPM1 25348397 N/A physical interaction ComPPI
DBN1 TPM1 25348397 N/A physical interaction ComPPI
TSSC4 TPM1 25348397 N/A physical interaction ComPPI
OGA TPM1 25348397 N/A physical interaction ComPPI
RPS3 TPM1 25348397 N/A physical interaction ComPPI
TWNK TPM1 25348397 N/A physical interaction ComPPI
SCLT1 TPM1 25348397 N/A physical interaction ComPPI
MYH2 TPM1 25348397 N/A physical interaction ComPPI
ETFA TPM1 25348397 N/A physical interaction ComPPI
CNN2 TPM1 25348397 N/A physical interaction ComPPI
AHCYL1 TPM1 25348397 N/A physical interaction ComPPI
NDUFB10 TPM1 25348397 N/A physical interaction ComPPI
TPM1 ERG 25348397 N/A physical interaction ComPPI
TPM1 LRRK2 25348397 N/A physical interaction ComPPI
TPM1 ACTC1 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
TPM1 SRXN1 25348397 N/A physical interaction ComPPI
TPM1 RBM15 25348397 N/A physical interaction ComPPI
TPM1 NUDCD2 25348397 N/A physical interaction ComPPI
TPM1 SULT1A1 25348397 N/A physical interaction ComPPI
TPM1 THOC2 25348397 N/A physical interaction ComPPI
TPM1 TGFBR1 25348397 N/A physical interaction ComPPI
TPM1 FOXK1 25348397 N/A physical interaction ComPPI
TPM1 TP53 25348397 N/A physical interaction ComPPI
TPM1 SYCE1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TPM1 IKBKG 25348397 N/A physical interaction ComPPI
TPM1 KLHL21 25348397 N/A physical interaction ComPPI
TPM1 CCDC102A 25348397 N/A physical interaction ComPPI
TPM1 CNTLN 25348397 N/A physical interaction ComPPI
TPM1 ENDOG 25348397 N/A physical interaction ComPPI
TPM1 MYH6 25348397 N/A physical interaction ComPPI
TPM1 ATP5PB 25348397 N/A physical interaction ComPPI
TPM1 MYH7B 25348397 N/A physical interaction ComPPI
TPM1 MYH8 25348397 N/A physical interaction ComPPI
TPM1 CAPZA2 25348397 N/A physical interaction ComPPI
TPM1 MYO19 25348397 N/A physical interaction ComPPI
TPM1 CFAP97 25348397 N/A physical interaction ComPPI
TPM1 ZNF746 25348397 N/A physical interaction ComPPI
TPM1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM1 G3BP1 25348397 N/A physical interaction ComPPI
TPM1 CLIP4 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TPM1 S100A2 14525934 9092943 N/A experimental interaction detection HPRD
TMOD2 TPM1 14525934 8886980 N/A experimental interaction detection HPRD
TPM1 PKD2 12527301 14525934 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
TPM1 ACTB 14525934 9108196 N/A experimental interaction detection HPRD
WTAP TPM1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
ESR2 TPM1 21951318 24234451 association anti tag coimmunoprecipitation IntAct
TPM1 GALNT18 24234451 30021884 physical association cross-linking study IntAct
TPM1 CBS 24234451 30021884 physical association cross-linking study IntAct
TPM1 CCDC112 24234451 30021884 physical association cross-linking study IntAct
L1TD1 TPM1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
PRKCA TPM1 16094730 27898060 N/A N/A OmniPath
PIK3CA TPM1 16094730 27898060 N/A N/A OmniPath
DAPK1 TPM1 17895359 23157718 23712688 27898060 stimulant N/A OmniPath

Visualization










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