GENE：CLDN3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CLDN3 |
| FullNmae | claudin 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2045 |
| EnsembleID | ENSG00000165215 |
| Uniprot | O15551 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CLDN3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CLDN3 | GO:0001666,GO:0001934,GO:0003382,GO:0004888,GO:0005198,GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0005923,GO:0005923,GO:0007155,GO:0008285,GO:0010628,GO:0010629,GO:0014045,GO:0016020,GO:0016327,GO:0016328,GO:0016338,GO:0022604,GO:0030036,GO:0030335,GO:0030336,GO:0032991,GO:0034331,GO:0035633,GO:0042802,GO:0043296,GO:0045471,GO:0061045,GO:0070160,GO:0070160,GO:0070830,GO:0070830,GO:0090303,GO:0090559,GO:0140459,GO:0150111,GO:1901890,GO:1903348,GO:1905050 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CLDN3 | hsa:1365 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| CLDN3 | hsa:1365 | path:hsa04530 | Tight junction - Homo sapiens (human) |
| CLDN3 | hsa:1365 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| CLDN3 | hsa:1365 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| CLDN3 | hsa:1365 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | CLDN3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CLDN3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | CLDN3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CLDN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CLDN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CLDN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CLDN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CLDN3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SNAI1 | CLDN3 | 19874710 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CLDN3 | 17986852 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | CLDN3 | 17986852 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | CLDN3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CLDN1 | CLDN3 | 25361965 | interaction type | N/A | PTMCode2 |
| CLDN3 | CLDN1 | 25361965 | interaction type | N/A | PTMCode2 |
| CLDN3 | CLDN5 | 25361965 | interaction type | N/A | PTMCode2 |
| CLDN5 | CLDN3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTSS | CLDN3 | 25348397 | N/A | protease assay,protein cleavage | ComPPI |
| CLDN1 | CLDN3 | 10562289 12909588 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CLDN5 | CLDN3 | 12909588 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| GOLM1 | CLDN3 | 24234451 25348397 27569582 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| APP | CLDN3 | 25348397 | N/A | physical interaction | ComPPI |
| TJP1 | CLDN3 | 10601346 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| WNK4 | CLDN3 | 14525934 15070779 | N/A | experimental interaction detection | HPRD |
| PRKACA | CLDN3 | 14525934 15905176 | N/A | experimental interaction detection | HPRD |
| CLDN3 | POM121 | 14525934 16169070 | N/A | two hybrid | HPRD |
| PRKACA | CLDN3 | 15905176 27898060 | N/A | N/A | OmniPath |