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GENE：FOXA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOXA2
FullNmae forkhead box A2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5022
EnsembleID ENSG00000125798
Uniprot Q9Y261

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOXA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FOXA2 GO:0000432,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001708,GO:0003676,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006325,GO:0006351,GO:0006357,GO:0006357,GO:0008344,GO:0009653,GO:0010719,GO:0019904,GO:0030054,GO:0030154,GO:0030193,GO:0031018,GO:0033132,GO:0040019,GO:0043433,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0061178,GO:0061987,GO:0070741,GO:0071542,GO:0071542,GO:0071542,GO:0090009,GO:1990837,GO:2000049,GO:2000543

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOXA2 hsa:3170 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
FOXA2 hsa:3170 path:hsa04950 Maturity onset diabetes of the young - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 FOXA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FOXA2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 FOXA2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 FOXA2 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FOXA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GLI2 FOXA2 19360354 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 FOXA2 21625455 trascriptional regulation,stimulation inferred by curator TFlink
USF1 FOXA2 22460558 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 FOXA2 N/A trascriptional regulation,stimulation inferred by curator TFlink
GLI3 FOXA2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 FOXA2 18185580 24449834 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C28B2 FOXA2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F FOXA2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC FOXA2 25416803 28098868 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008DA94 FOXA2 25416803 28367241 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000043F369 FOXA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E5ECC FOXA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006DA05 FOXA2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHUK FOXA2 22135298 phosphorylation N/A PhosphoSite
AKT1 FOXA2 22135298 phosphorylation N/A PhosphoSite
ONECUT1 FOXA2 25361965 interaction type N/A PTMCode2
FOXA2 ONECUT1 25361965 interaction type N/A PTMCode2
FOXA2 OTX2 25361965 interaction type N/A PTMCode2
OTX2 FOXA2 25361965 interaction type N/A PTMCode2
FOXA2 TLE1 25361965 interaction type N/A PTMCode2
TLE1 FOXA2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TLE1 FOXA2 10748198 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NCOA1 FOXA2 11069927 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PPARGC1B FOXA2 25348397 N/A physical interaction ComPPI
LHX1 FOXA2 25348397 N/A physical interaction ComPPI
FOXA1 FOXA2 19769745 24234451 25348397 colocalization cosedimentation,cosedimentation in solution ComPPI,IntAct
ONECUT1 FOXA2 12509444 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FOXA2 OTX2 10623575 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FOXA2 GSC 12642491 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FOXA2 HOXA5 12163409 12642491 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FOXA2 MIP 12642491 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FOXA2 HOXD13 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 SATB2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 ADAR 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 AGL 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 DACH1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 FOXN2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 HOXB13 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 NACC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXA2 SALL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EN2 FOXA2 12642491 14525934 N/A experimental interaction detection HPRD
FOXA2 FOXA2 24234451 25609649 association tandem affinity purification IntAct
CHUK FOXA2 22196886 27898060 inhibition N/A OmniPath
AKT1 FOXA2 14500912 23416070 27898060 stimulant N/A OmniPath
FOXA2 OTX2 10623575 12642491 27898060 inhibition N/A OmniPath

Visualization










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