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GENE：DAB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DAB2
FullNmae DAB adaptor protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2662
EnsembleID ENSG00000153071
Uniprot P98082

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DAB2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DAB2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DAB2 GO:0000122,GO:0001650,GO:0001934,GO:0005515,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005905,GO:0005925,GO:0006898,GO:0006915,GO:0007179,GO:0010718,GO:0010977,GO:0015031,GO:0016055,GO:0030136,GO:0030308,GO:0030335,GO:0030665,GO:0032091,GO:0032349,GO:0032436,GO:0035026,GO:0035615,GO:0038024,GO:0043066,GO:0043231,GO:0045807,GO:0045807,GO:0045944,GO:0046332,GO:0048268,GO:0048471,GO:0048545,GO:0050680,GO:0050750,GO:0060391,GO:0060766,GO:0070373,GO:0071364,GO:0090090,GO:0090090,GO:0090090,GO:1900026,GO:1902074,GO:1903077,GO:2000096,GO:2000370,GO:2000643,GO:2000860

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DAB2 hsa:1601 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DAB2 AMER1 15518237 17318175 19561074 19581931 20460648 21304492 21498506 26192618 interaction type N/A ACSN
DAB2 APC 15518237 17318175 19561074 19581931 20460648 21304492 21498506 26192618 interaction type N/A ACSN
DAB2 CDK1 12881709 23180781 physical association anti tag coimmunoprecipitation InnateDB
DAB2 PIN1 12881709 23180781 physical association pull down InnateDB
DAB2 DVL3 12805222 21071413 23331499 stimulation N/A SignaLink,SignaLink
DAB2 TGFBR1 11387212 23331499 stimulation N/A SignaLink
DAB2 TGFBR2 11387212 23331499 stimulation N/A SignaLink
DAB2 SMAD2 11387212 23331499 stimulation N/A SignaLink
DAB2 CSK 12473651 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DAB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 DAB2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DAB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DAB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DAB2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DAB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA6 DAB2 16024609 trascriptional regulation,stimulation inferred by curator TFlink
VHL DAB2 15824735 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DAB2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 DAB2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 DAB2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 DAB2 24037530 25416803 25892549 26273410 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000FFE5F DAB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB DAB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A DAB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F DAB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 DAB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 DAB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5FFC DAB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 DAB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB DAB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 DAB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 DAB2 25416803 26769181 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD DAB2 22135298 phosphorylation N/A PhosphoSite
PRKCG DAB2 22135298 phosphorylation N/A PhosphoSite
AXIN1 DAB2 25361965 interaction type N/A PTMCode2
DAB2 AXIN1 25361965 interaction type N/A PTMCode2
DAB2IP DAB2 25361965 interaction type N/A PTMCode2
DAB2 DAB2IP 25361965 interaction type N/A PTMCode2
ITGB3 DAB2 25361965 interaction type N/A PTMCode2
DAB2 ITGB3 25361965 interaction type N/A PTMCode2
DAB2 GRB2 25361965 interaction type N/A PTMCode2
GRB2 DAB2 25361965 interaction type N/A PTMCode2
DAB2 SRC 25361965 interaction type N/A PTMCode2
SRC DAB2 25361965 interaction type N/A PTMCode2
DAB2 TGFBR2 25361965 interaction type N/A PTMCode2
TGFBR2 DAB2 25361965 interaction type N/A PTMCode2
DAB2 MYO6 25361965 interaction type N/A PTMCode2
MYO6 DAB2 25361965 interaction type N/A PTMCode2
DAB2 FGR 25361965 interaction type N/A PTMCode2
FGR DAB2 25361965 interaction type N/A PTMCode2
LRP2 DAB2 25361965 interaction type N/A PTMCode2
DAB2 LRP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 DAB2 12881709 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPRE1 DAB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC23B DAB2 25348397 N/A physical interaction ComPPI
SH3KBP1 DAB2 14596919 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 DAB2 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ITGB5 DAB2 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACTB DAB2 25348397 N/A physical interaction ComPPI
PPP1CB DAB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CPSF7 DAB2 25348397 N/A physical interaction ComPPI
SMURF2 DAB2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DAB2 ITGB3 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DAB2 PRKCB 10542228 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DAB2 PRKCD 10542228 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DAB2 PRKCG 10542228 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DAB2 SRC 12473651 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DAB2 GRB2 10542228 11371563 14525934 16713569 17474147 20936779 22323290 24234451 25348397 27898060 9569023 physical association experimental interaction detection,peptide array,physical interaction,two hybrid pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
DAB2 TGFBR2 11387212 14525934 24234451 25348397 association cross-linking study,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DAB2 MYO6 11906161 11967127 14525934 15837803 16713569 17187061 18429820 19855435 22323290 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
DAB2 AP2M1 11247302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DAB2 SMAD2 11387212 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DAB2 DVL3 12805222 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
DAB2 SMAD3 11387212 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DAB2 MIB1 11812785 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DAB2 DIP2A 11812785 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DAB2 AXIN1 12805222 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DAB2 CSK 12473651 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DAB2 NECAP1 14525934 17762867 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DAB2 LRP2 10769163 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
DAB2 CDK1 12881709 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DAB2 DVL2 25348397 N/A physical interaction ComPPI
DAB2 DVL1 25348397 N/A physical interaction ComPPI
DAB2 DVL1P1 25348397 N/A physical interaction ComPPI
DAB2 TGFBR1 11387212 14525934 24234451 25348397 association cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
DAB2 LDLR 25348397 N/A physical interaction ComPPI
DAB2 APP 25348397 N/A physical interaction ComPPI
DAB2 APLP1 25348397 N/A physical interaction ComPPI
DAB2 APLP2 25348397 N/A physical interaction ComPPI
DAB2 INPP5D 25348397 N/A physical interaction ComPPI
DAB2 LRP1 25348397 N/A physical interaction ComPPI
DAB2 AP2A2 22323290 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
DAB2 DAB2IP 25348397 N/A physical interaction ComPPI
DAB2 FGR 12473651 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DAB2 ITSN1 25348397 N/A physical interaction ComPPI
DAB2 ATXN1L 25348397 N/A physical interaction ComPPI
DAB2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
DAB2 HSPA1A 25348397 N/A physical interaction ComPPI
DAB2 HSPA1B 25348397 N/A physical interaction ComPPI
DAB2 AP2B1 25348397 N/A physical interaction ComPPI
DAB2 FCHO2 25348397 N/A physical interaction ComPPI
DAB2 AP2A1 25348397 N/A physical interaction ComPPI
DAB2 ACOT9 25348397 N/A physical interaction ComPPI
DAB2 CLTC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 NUP155 25348397 N/A physical interaction ComPPI
DAB2 SEC24B 25348397 N/A physical interaction ComPPI
DAB2 PRDX1 25348397 N/A physical interaction ComPPI
DAB2 MALT1 25348397 N/A physical interaction ComPPI
DAB2 SF3B2 25348397 N/A physical interaction ComPPI
DAB2 CCNT1 25348397 N/A physical interaction ComPPI
DAB2 YLPM1 25348397 N/A physical interaction ComPPI
DAB2 PYCR1 25348397 N/A physical interaction ComPPI
DAB2 AURKA 25348397 N/A physical interaction ComPPI
DAB2 CPSF6 25348397 N/A physical interaction ComPPI
DAB2 HSPH1 25348397 N/A physical interaction ComPPI
DAB2 TRIO 25348397 N/A physical interaction ComPPI
DAB2 HNRNPL 25348397 N/A physical interaction ComPPI
DAB2 AHCY 25348397 N/A physical interaction ComPPI
DAB2 TFAP2A 25348397 N/A physical interaction ComPPI
DAB2 CFTR 17110338 20351096 24234451 25348397 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
DAB2 CDC16 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DAB2 SLC25A41 25348397 N/A physical interaction ComPPI
DAB2 XPO1 25348397 N/A physical interaction ComPPI
DAB2 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 FLNA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 GAK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 PICALM 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 ACTR2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 ANLN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 MYO18A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 SERPINB4 25348397 N/A physical interaction ComPPI
DAB2 BECN1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
DAB2 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DAB2 NCK1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DAB2 PIK3R1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DAB2 LRP6 22491013 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
DAB2 JUN 15894542 24234451 25348397 phosphorylation reaction in-gel kinase assay ComPPI,IntAct
DAB2 MAPK8 15894542 24234451 25348397 phosphorylation reaction in-gel kinase assay ComPPI,IntAct
DAB2 EPS15 22648170 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
DAB2 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IQGAP1 DAB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RTRAF DAB2 25348397 N/A physical interaction ComPPI
PRKCB DAB2 10542228 27898060 N/A N/A OmniPath
PRKCD DAB2 10542228 15280374 27898060 inhibition,stimulant N/A OmniPath
DAB2 TGFBR2 11387212 27898060 stimulant N/A OmniPath
PIN1 DAB2 12881709 27898060 N/A N/A OmniPath
PRKCG DAB2 10542228 11812785 15280374 27898060 stimulant N/A OmniPath
DAB2 LRP6 22491013 27898060 inhibition N/A OmniPath
MAPK3 DAB2 10542228 11812785 27898060 N/A N/A OmniPath
DAB2 DVL3 12805222 27898060 stimulant N/A OmniPath
DAB2 SMAD2 11387212 27898060 stimulant N/A OmniPath
DAB2 TGFBR1 11387212 27898060 stimulant N/A OmniPath
DAB2 CSK 12473651 27898060 stimulant N/A OmniPath
DAB2 DAB2IP 11812785 27858941 27898060 stimulant N/A OmniPath

Visualization










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