GENE：FGF19
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FGF19 |
| FullNmae | fibroblast growth factor 19 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3675 |
| EnsembleID | ENSG00000162344 |
| Uniprot | O95750 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FGF19 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FGF19 | GO:0001755,GO:0001934,GO:0001934,GO:0005104,GO:0005104,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0007399,GO:0007507,GO:0008083,GO:0008284,GO:0008284,GO:0008543,GO:0008543,GO:0008543,GO:0009617,GO:0009887,GO:0010628,GO:0010629,GO:0014070,GO:0015721,GO:0030154,GO:0030334,GO:0045471,GO:0046326,GO:0046330,GO:0070374,GO:0070858 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FGF19 | hsa:9965 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| FGF19 | hsa:9965 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | FGF19 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | FGF19 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | FGF19 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF4 | FGF19 | 23205607 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXC1 | FGF19 | 17000708 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR1I2 | FGF19 | 17696253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000042935A | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000367985 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D5391 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004407DC | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000166778 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000451A1 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | FGF19 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C85C7 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00004818BD | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000045ED38 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000027F5F3 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000759B6A | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000547F6A | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076E54 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0B46 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B7450 | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D15B | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | FGF19 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FGFR1 | FGF19 | 19706524 24234451 25348397 | physical association | physical interaction,solid phase assay | ComPPI,IntAct |
| FGF19 | NR1H4 | 22561792 24234451 24321096 | association | chromatin immunoprecipitation assay | IntAct |
| FGF19 | FGFR1 | 16597617 27898060 | stimulant | N/A | OmniPath |
| FGF19 | FGFR3 | 16597617 27898060 | stimulant | N/A | OmniPath |
| FGF19 | FGFR2 | 16597617 27898060 | stimulant | N/A | OmniPath |