GENE：PAG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PAG1 |
| FullNmae | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30043 |
| EnsembleID | ENSG00000076641 |
| Uniprot | Q9NWQ8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PAG1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PAG1 | GO:0002250,GO:0005515,GO:0005886,GO:0005886,GO:0007165,GO:0035556,GO:0035556,GO:0035591,GO:0042169,GO:0042169,GO:0045121,GO:0045121,GO:0050863,GO:0050868 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PAG1 | ABL1 | 20005715 | interaction type | N/A | PSP |
| PAG1 | LCK | 20005715 | interaction type | N/A | PSP |
| PAG1 | FYN | 20005715 | interaction type | N/A | PSP |
| PAG1 | LYN | 20005715 | interaction type | N/A | PSP |
| PAG1 | PTPN6 | 20005715 | interaction type | N/A | PSP |
| PAG1 | CSK | 20005715 | interaction type | N/A | PSP |
| PAG1 | ZAP70 | 20005715 | interaction type | N/A | PSP |
| PAG1 | SYK | 20005715 | interaction type | N/A | PSP |
| PAG1 | PTPN11 | 20005715 | interaction type | N/A | PSP |
| PAG1 | ABL1 | 18988627 20005715 21071413 9334312 | N/A | N/A | SignaLink |
| PAG1 | CSK | 20005715 20005715 | N/A | N/A | SignaLink |
| PAG1 | FYN | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| PAG1 | LCK | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| PAG1 | LYN | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| PAG1 | PTPN11 | 10790433 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| PAG1 | PTPN6 | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| PAG1 | SYK | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| PAG1 | ZAP70 | 10790433 10790433 18988627 20005715 20005715 21071413 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PAG1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PAG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PAG1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PAG1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PAG1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | PAG1 | 18591254 22473208 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS0000508C13 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F507C | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000072B4C8 | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E6EFA | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FA076 | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C36BD | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005606AA | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | PAG1 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | PAG1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F0C23 | PAG1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | PAG1 | 20371350 23706177 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000451A1 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0920 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D2F5 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040780F | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000166778 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000284586 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | PAG1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | PAG1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | PAG1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000032FC1A | PAG1 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D6605 | PAG1 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | PAG1 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | PAG1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CSK | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | CSK | 25361965 | interaction type | N/A | PTMCode2 |
| LCP2 | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | LCP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | HTRA2 | 25361965 | interaction type | N/A | PTMCode2 |
| HTRA2 | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | ZAP70 | 25361965 | interaction type | N/A | PTMCode2 |
| ZAP70 | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| LCK | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| FYN | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| PAG1 | SYK | 25361965 | interaction type | N/A | PTMCode2 |
| SYK | PAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LCP2 | PAG1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| HOXB5 | PAG1 | 25348397 | N/A | physical interaction | ComPPI |
| MED21 | PAG1 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN6 | PAG1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CRK | PAG1 | 18070987 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RACK1 | PAG1 | 23866081 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| VAV1 | PAG1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SYK | PAG1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PAG1 | LYN | 10790433 14525934 18070987 23866081 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| PAG1 | PTPN11 | 10790433 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PAG1 | ZAP70 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PAG1 | GRB2 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PAG1 | SHC1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PAG1 | SLC9A3R1 | 11684085 14525934 24234451 25348397 | physical association | two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| PAG1 | GLS2 | 11163757 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PAG1 | HTRA2 | 14525934 16413409 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| PAG1 | CSK | 10790433 14525934 18070987 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| PAG1 | FYN | 10790433 14525934 18056706 23866081 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,peptide array,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| PAG1 | RASA1 | 10790433 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PAG1 | LCK | 10790433 14525934 18070987 24234451 25348397 | association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| PAG1 | ABL1 | 14525934 25348397 9334312 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| PAG1 | SLC25A41 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | CCR1 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | TMEM185A | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | CDH1 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | CLPB | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | GJB7 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | CYP2S1 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | ACBD7 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | PCDHGC3 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | RPS27 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | NTRK3 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | NCSTN | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | PMS1 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | C1QL4 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | S1PR2 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | SERHL2 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | GPR141 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | GSTK1 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | FKBP11 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | DUSP22 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | PCK2 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | ZNF517 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | MTUS2 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | TIGD5 | 25348397 | N/A | physical interaction | ComPPI |
| PAG1 | STAT3 | 18070987 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PAG1 | SRC | 18070987 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PAG1 | PRKCB | 23866081 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PAG1 | EGFR | 23866081 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SRC | PAG1 | 10790433 27898060 | N/A | N/A | OmniPath |
| LYN | PAG1 | 10790433 16920712 18070987 18083107 19690332 23866081 27898060 | N/A | N/A | OmniPath |
| SLC9A3R1 | PAG1 | 11684085 27898060 | N/A | N/A | OmniPath |
| FYN | PAG1 | 10790433 18056706 18070987 18083107 19690332 23866081 27898060 | N/A | N/A | OmniPath |
| HDAC3 | PAG1 | 18241676 27898060 | inhibition | N/A | OmniPath |
| PAG1 | NFE2L2 | 11683914 27898060 | N/A | N/A | OmniPath |
| PTPN11 | PAG1 | 10790433 14967142 27898060 | inhibition | N/A | OmniPath |
| NFKBIE | PAG1 | 18241676 27898060 | inhibition | N/A | OmniPath |
| PAG1 | CSK | 10790433 12665526 27898060 | inhibition,stimulant | N/A | OmniPath |