GENE：TNC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TNC |
| FullNmae | tenascin C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5318 |
| EnsembleID | ENSG00000041982 |
| Uniprot | P24821 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TNC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TNC | GO:0001558,GO:0001649,GO:0002009,GO:0005201,GO:0005201,GO:0005515,GO:0005576,GO:0005576,GO:0005604,GO:0005614,GO:0005615,GO:0005615,GO:0005788,GO:0005925,GO:0007155,GO:0007162,GO:0007528,GO:0008284,GO:0009611,GO:0009611,GO:0009612,GO:0010628,GO:0014012,GO:0016020,GO:0030155,GO:0030155,GO:0030334,GO:0042475,GO:0045471,GO:0045545,GO:0050727,GO:0060447,GO:0060739,GO:0060740,GO:0062023,GO:0062023,GO:0062023,GO:0071300,GO:0071305,GO:0071774,GO:0071799,GO:0090733,GO:0098966 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TNC | hsa:3371 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| TNC | hsa:3371 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| TNC | hsa:3371 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| TNC | hsa:3371 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| TNC | hsa:3371 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TNC | ACTA2 | 15059978 16572188 20833777 26192618 | interaction type | N/A | ACSN |
| SMAD3 | TNC | 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 | interaction type | N/A | ACSN |
| SMAD4 | TNC | 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 | interaction type | N/A | ACSN |
| SP1 | TNC | 10964912 11007770 11013220 15001984 17705132 18353785 21252118 23338822 26192618 | interaction type | N/A | ACSN |
| ETS1 | TNC | 15001984 15111329 15181457 16391805 17615296 21041997 21081489 22608498 26192618 9157999 | interaction type | N/A | ACSN |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TNC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | TNC | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR2 | TNC | 20034404 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | TNC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | TNC | 18922183 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TNC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TNC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TNC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | TNC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TNC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | TNC | 10618716 15001984 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | TNC | 10618716 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | TNC | 9154819 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | TNC | 20723226 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | TNC | 20723226 9154819 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | TNC | 15001984 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | TNC | 15001984 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | TNC | 10618716 15001984 16245312 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | TNC | 10618716 15001984 16245312 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ERG | TNC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | TNC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD2 | TNC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | TNC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | TNC | 18185580 | rna interference,inhibition | array technology,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
| URS0000237AF9 | TNC | 18185580 23806264 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00002B3783 | TNC | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B2B | TNC | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AFAD1 | TNC | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A122A | TNC | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A4ABF | TNC | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TNC | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | TNC | 25361965 | interaction type | N/A | PTMCode2 |
| TNC | ITGA5 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA5 | TNC | 25361965 | interaction type | N/A | PTMCode2 |
| TNNC1 | TNC | 25361965 | interaction type | N/A | PTMCode2 |
| TNC | TNNC1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CLU | TNC | 25348397 | N/A | pull down | ComPPI |
| MEP1B | TNC | 19748582 25348397 27898060 | N/A | protease assay | ComPPI,OmniPath |
| EGFR | TNC | 11470832 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| NCAN | TNC | 14525934 25348397 27898060 9341124 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| TLR4 | TNC | 24234451 25348397 29150600 | N/A | enzyme linked immunosorbent assay | ComPPI,IntAct |
| PGK1 | TNC | 25348397 | N/A | pull down | ComPPI |
| NID2 | TNC | 25348397 | N/A | pull down | ComPPI |
| HGF | TNC | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| TNC | FN1 | 14525934 25348397 7499434 | N/A | experimental interaction detection,physical interaction,enzyme linked immunosorbent assay | ComPPI,HPRD |
| TNC | COL5A1 | 20979576 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid | ComPPI,IntAct |
| TNC | SMOC2 | 25348397 | N/A | surface plasmon resonance | ComPPI |
| TNC | SMOC1 | 25348397 | N/A | pull down | ComPPI |
| TNC | PTPRB | 11313993 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
| CNTN1 | TNC | 10103110 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
| TNC | TNC | 24234451 29150600 | N/A | enzyme linked immunosorbent assay | IntAct |
| MAPT | TNC | 24234451 26402096 | association | anti bait coimmunoprecipitation | IntAct |
| TNC | ITGB1 | 14715956 27898060 | stimulant | N/A | OmniPath |
| TNC | ITGA7 | 14715956 27898060 | stimulant | N/A | OmniPath |