GENE：DLL1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DLL1 |
| FullNmae | delta like canonical Notch ligand 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2908 |
| EnsembleID | ENSG00000198719 |
| Uniprot | O00548 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DLL1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DLL1 | GO:0001709,GO:0001756,GO:0001757,GO:0001947,GO:0002085,GO:0002315,GO:0003323,GO:0005112,GO:0005112,GO:0005509,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0007219,GO:0007219,GO:0007219,GO:0007219,GO:0007219,GO:0007368,GO:0007386,GO:0008217,GO:0008284,GO:0008285,GO:0009954,GO:0010628,GO:0014002,GO:0014807,GO:0016324,GO:0021510,GO:0021688,GO:0021693,GO:0030097,GO:0030099,GO:0030154,GO:0030155,GO:0030857,GO:0030947,GO:0030957,GO:0031410,GO:0032693,GO:0034351,GO:0035265,GO:0040008,GO:0042491,GO:0045121,GO:0045596,GO:0045605,GO:0045608,GO:0045638,GO:0045662,GO:0045665,GO:0045746,GO:0045747,GO:0045807,GO:0045944,GO:0046331,GO:0048018,GO:0048630,GO:0048631,GO:0048633,GO:0048665,GO:0050767,GO:0051302,GO:0060041,GO:0060042,GO:0060563,GO:0060853,GO:0070986,GO:0072006,GO:0072014,GO:0072070,GO:0072583,GO:0097009,GO:0097102,GO:0097110,GO:0097150,GO:0097150,GO:0098773,GO:1900746,GO:1903672,GO:2000726 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DLL1 | hsa:28514 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| DLL1 | hsa:28514 | path:hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| DLL1 | hsa:28514 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| DLL1 | hsa:28514 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| DLL1 | hsa:28514 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| DLL1 | hsa:28514 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOTCH1 | DLL1 | 20351093 21985982 22363487 26192618 | interaction type,stimulation,association | N/A | ACSN,SignaLink |
| PSEN1 | DLL1 | 22330899 22363130 26192618 | interaction type | N/A | ACSN |
| ADAM10 | DLL1 | 18676862 19601831 19704010 19726682 22006996 26192618 | interaction type | N/A | ACSN |
| ADAM17 | DLL1 | 18676862 19601831 19704010 19726682 22006996 26192618 | interaction type | N/A | ACSN |
| NUMB | DLL1 | 19567869 20940030 21841793 22330899 22363130 26192618 | interaction type | N/A | ACSN |
| DLL1 | DLL1 | 16140393 26467481 | bind,up-regulates activity | N/A | Signor |
| LFNG | DLL1 | 11346656 23331499 | stimulation | N/A | SignaLink,SignaLink |
| NOTCH2 | DLL1 | 22390640 | interaction type,stimulation | N/A | SignaLink |
| MFNG | DLL1 | 11346656 12036964 23331499 | interaction type | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DLL1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | DLL1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | DLL1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | DLL1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | DLL1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | DLL1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | DLL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LEF1 | DLL1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000EED18 | DLL1 | 14697198 19461653 20144220 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00000EED18 | DLL1 | 14697198 19461653 20144220 23327670 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | DLL1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002C0FCB | DLL1 | 25416803 28163094 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| JAG2 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | JAG2 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | POFUT1 | 25361965 | interaction type | N/A | PTMCode2 |
| POFUT1 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | MAGI1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAGI1 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| ADAM10 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | ADAM10 | 25361965 | interaction type | N/A | PTMCode2 |
| NOTCH1 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | NOTCH1 | 25361965 | interaction type | N/A | PTMCode2 |
| JAG1 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | JAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| RFNG | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | RFNG | 25361965 | interaction type | N/A | PTMCode2 |
| MAGI2 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | MAGI2 | 25361965 | interaction type | N/A | PTMCode2 |
| LFNG | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | LFNG | 25361965 | interaction type | N/A | PTMCode2 |
| NOTCH3 | DLL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DLL1 | NOTCH3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CNKSR3 | DLL1 | 14525934 15509766 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CCN3 | DLL1 | 12050162 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NOTCH1 | DLL1 | 11006133 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| DLL1 | NOTCH2 | 10958687 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| DLL1 | NOTCH3 | 11006133 12482954 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| DLL1 | ADAM10 | 12794186 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| DLL1 | MFNG | 12036964 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| DLL1 | POFUT1 | 12036964 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| DLL1 | MAGI2 | 14525934 14529612 24025447 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| DLL1 | PSEN1 | 12794186 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DLL1 | MIB1 | 25348397 | N/A | physical interaction | ComPPI |
| DLL1 | EPN1 | 25348397 | N/A | physical interaction | ComPPI |
| SYNJ2BP | DLL1 | 24025447 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| DLL1 | DLL1 | 12794186 14525934 | N/A | experimental interaction detection | HPRD |
| DLL1 | JAG2 | 16141228 27898060 | N/A | N/A | OmniPath |
| LFNG | DLL1 | 11346656 27898060 | stimulant | N/A | OmniPath |
| DLL1 | NOTCH1 | 11006133 15358736 16140393 17537801 27898060 | stimulant | N/A | OmniPath |
| NOTCH1 | DLL1 | 11006133 15358736 17537801 27898060 | inhibition | N/A | OmniPath |
| MIB1 | DLL1 | 15824097 16000382 16140393 16857196 23162128 27898060 | stimulant | N/A | OmniPath |
| DLL1 | NOTCH2 | 10958687 11346656 23111325 27898060 9244302 | stimulant | N/A | OmniPath |
| DLL1 | NOTCH3 | 11006133 12482954 27898060 | stimulant | N/A | OmniPath |