Gene Information gene info

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GENE：DUSP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DUSP1
FullNmae dual specificity phosphatase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3064
EnsembleID ENSG00000120129
Uniprot P28562

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DUSP1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DUSP1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DUSP1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DUSP1 GO:0001706,GO:0004722,GO:0004725,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0007049,GO:0007162,GO:0008138,GO:0008285,GO:0008330,GO:0017017,GO:0017017,GO:0017018,GO:0033550,GO:0035335,GO:0035335,GO:0035970,GO:0043407,GO:0043409,GO:0051019,GO:0051447,GO:0070262,GO:0090027,GO:0090266,GO:1903753,GO:1903753,GO:1990869

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DUSP1 hsa:1843 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
DUSP1 hsa:1843 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
DUSP1 hsa:1843 path:hsa05012 Parkinson disease - Homo sapiens (human)
DUSP1 hsa:1843 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT6 DUSP1 10485906 12223527 12244147 14610620 15634881 23124025 24204259 26192618 interaction type N/A ACSN
IL10 DUSP1 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
CREB1 DUSP1 19815709 26192618 interaction type N/A ACSN
DUSP1 MAPK9 11359773 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK10 DUSP1 11359773 23180781 physical association anti tag coimmunoprecipitation InnateDB
DUSP1 MAPK14 11278799 11359773 20936779 23180781 23331499 7535770 8626452 stimulation,physical association anti tag coimmunoprecipitation,two hybrid InnateDB,SignaLink
MAPK11 DUSP1 11359773 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 DUSP1 11278799 23180781 physical association two hybrid InnateDB
MAPK1 DUSP1 11278799 23180781 physical association two hybrid InnateDB
DUSP1 MAPK8 11278799 23180781 23331499 9020184 stimulation,physical association two hybrid InnateDB,SignaLink
ELAVL1 DUSP1 18490444 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
ILF3 DUSP1 18490444 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
DUSP1 TIAL1 18490444 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
TIA1 DUSP1 18490444 23180781 physical association anti tag coimmunoprecipitation InnateDB
DUSP1 CEBPB 18682532 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR3C1 DUSP1 18682532 21060794 23180781 24418482 physical association anti tag coimmunoprecipitation InnateDB
EP300 DUSP1 21060794 23180781 physical association anti tag coimmunoprecipitation InnateDB
DUSP1 CREBBP 21060794 23180781 physical association anti tag coimmunoprecipitation InnateDB
DUSP1 EP300 21060794 23180781 physical association anti tag coimmunoprecipitation InnateDB
PAF1 DUSP1 23180781 26217014 physical association anti tag coimmunoprecipitation InnateDB
RTF1 DUSP1 23180781 26217014 physical association anti tag coimmunoprecipitation InnateDB
DUSP1 MAPK1 10617468 11278799 21071413 23331499 9922370 stimulation N/A SignaLink,SignaLink
PRDX1 DUSP1 23334324 interaction type,stimulation N/A SignaLink
PBK DUSP1 21715333 phosphorylation reaction,stimulation N/A SignaLink
DUSP1 MAPK3 10617468 23331499 9922370 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DUSP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPB DUSP1 18682532 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ETS1 DUSP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DUSP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR3C1 DUSP1 18682532 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
YBX1 DUSP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 DUSP1 12890671 15611668 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SMARCA4 DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DUSP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 DUSP1 17681939 trascriptional regulation,stimulation inferred by curator TFlink
ATM DUSP1 17178844 trascriptional regulation,stimulation inferred by curator TFlink
CREM DUSP1 21325296 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DUSP1 17638884 trascriptional regulation,stimulation inferred by curator TFlink
PGR DUSP1 22020934 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 DUSP1 18342537 trascriptional regulation,stimulation inferred by curator TFlink
USF1 DUSP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 DUSP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 DUSP1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000171525 DUSP1 23807165 25416803 27696308 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000041FA2C DUSP1 24675421 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS00001EFBE3 DUSP1 23825193 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000054DF42 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C4762 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000096022 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 DUSP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 DUSP1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA2 DUSP1 22135298 phosphorylation N/A PhosphoSite
MAPK1 DUSP1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
DUSP1 MAPK1 25361965 interaction type N/A PTMCode2
DUSP1 SKP2 25361965 interaction type N/A PTMCode2
SKP2 DUSP1 25361965 interaction type N/A PTMCode2
DUSP1 CKS1B 25361965 interaction type N/A PTMCode2
CKS1B DUSP1 25361965 interaction type N/A PTMCode2
DUSP1 MAPK8 25361965 interaction type N/A PTMCode2
MAPK8 DUSP1 25361965 interaction type N/A PTMCode2
DUSP1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 DUSP1 25361965 interaction type N/A PTMCode2
MAPK14 DUSP1 25361965 interaction type N/A PTMCode2
DUSP1 MAPK14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK9 DUSP1 25348397 N/A physical interaction ComPPI
CKS1B DUSP1 14525934 16286470 18519678 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
ROR2 DUSP1 25348397 N/A physical interaction ComPPI
MAPK1 DUSP1 10617468 11278799 14525934 16286470 18519678 24234451 25348397 phosphorylation reaction,physical association two hybrid,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAPK8 DUSP1 11278799 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MAPK3 DUSP1 10617468 11278799 14525934 20347885 24234451 25241761 25348397 dephosphorylation reaction,phosphorylation reaction,physical association experimental interaction detection,physical interaction,protein kinase assay,phosphatase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAPK14 DUSP1 14525934 20347885 20936779 24234451 25241761 25348397 7535770 dephosphorylation reaction,physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,phosphatase assay,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
ICMT DUSP1 25348397 N/A physical interaction ComPPI
UBB DUSP1 14525934 16286470 24234451 25348397 ubiquitination reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,enzymatic study ComPPI,HPRD,IntAct
PTPN1 DUSP1 25348397 N/A physical interaction ComPPI
DUSP3 DUSP1 25348397 N/A physical interaction ComPPI
SNX17 DUSP1 25348397 N/A physical interaction ComPPI
IKBKB DUSP1 25348397 N/A physical interaction ComPPI
DUSP1 MAPK12 11062068 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
DUSP1 HSPA4 14525934 15677475 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DUSP1 SKP2 14525934 16286470 18519678 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
DUSP1 MAPK10 25348397 N/A physical interaction ComPPI
DUSP1 CHUK 25348397 N/A physical interaction ComPPI
DUSP1 FBXO32 25348397 N/A physical interaction ComPPI
DUSP1 POLR1H 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DUSP1 HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
DUSP1 ABHD14B 25348397 N/A physical interaction ComPPI
DUSP1 COPZ1 25348397 N/A physical interaction ComPPI
DUSP1 SRM 25348397 N/A physical interaction ComPPI
DUSP1 PARK7 25348397 N/A physical interaction ComPPI
DUSP1 AP3S1 25348397 N/A physical interaction ComPPI
DUSP1 APRT 25348397 N/A physical interaction ComPPI
DUSP1 NDUFA13 25348397 N/A physical interaction ComPPI
DUSP1 ACP1 25348397 N/A physical interaction ComPPI
DUSP1 ECHDC1 25348397 N/A physical interaction ComPPI
DUSP1 HDDC2 25348397 N/A physical interaction ComPPI
DUSP1 TMEM97 25348397 N/A physical interaction ComPPI
DUSP1 EYA2 25348397 N/A physical interaction ComPPI
DUSP1 MTMR12 25348397 N/A physical interaction ComPPI
DUSP1 AATK 25348397 N/A physical interaction ComPPI
DUSP1 CUL1 16286470 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC34 DUSP1 16286470 24234451 25348397 physical association enzymatic study ComPPI,IntAct
PRKCI DUSP1 25348397 N/A physical interaction ComPPI
COX4I1 DUSP1 25348397 N/A physical interaction ComPPI
BLVRA DUSP1 25348397 N/A physical interaction ComPPI
DUSP1 MAPK10 11359773 27898060 inhibition N/A OmniPath
MAPK10 DUSP1 11359773 27898060 N/A N/A OmniPath
EGR1 DUSP1 11165042 27898060 stimulant N/A OmniPath
ELAVL1 DUSP1 18490444 27898060 stimulant N/A OmniPath
DUSP1 MAPK9 11359773 27898060 8626452 inhibition N/A OmniPath
MAPK9 DUSP1 11359773 27898060 8626452 N/A N/A OmniPath
MAPK3 DUSP1 10617468 11278799 16286470 19892016 20347885 25241761 27898060 9922370 inhibition,stimulant N/A OmniPath
DUSP1 MAPK3 10617468 11278799 12676937 14695202 16286470 19892016 20347885 20858750 25241761 27898060 9922370 inhibition,stimulant N/A OmniPath
TP53 DUSP1 12890671 27898060 stimulant N/A OmniPath
DUSP1 MAPK14 11062068 11278799 11359773 12356755 18723442 18813292 19741200 20347885 20626350 20936779 21911040 25241761 27898060 7535770 8626452 9202001 inhibition,stimulant N/A OmniPath
MAPK14 DUSP1 11062068 11278799 11359773 12356755 20347885 20626350 20936779 21911040 25241761 27898060 7535770 8626452 stimulant N/A OmniPath
TIAL1 DUSP1 18490444 27898060 N/A N/A OmniPath
EP300 DUSP1 20626350 27898060 stimulant N/A OmniPath
MAPK1 DUSP1 10617468 11278799 11953434 16286470 18519678 19892016 27898060 8221888 8389479 8626452 9922370 9925641 inhibition,stimulant N/A OmniPath
DUSP1 MAPK1 10617468 11278799 11953434 16286470 18519678 19892016 27898060 7939666 8221888 8389479 8626452 9922370 9925641 inhibition,stimulant N/A OmniPath
TIA1 DUSP1 18490444 27898060 N/A N/A OmniPath
DUSP1 FANCI 17488615 27898060 inhibition N/A OmniPath
MAPK11 DUSP1 11359773 27898060 N/A N/A OmniPath
DUSP1 MAPK8 11278799 18813292 27898060 8626452 9020184 9202001 inhibition,stimulant N/A OmniPath
MAPK8 DUSP1 11278799 27898060 9020184 stimulant N/A OmniPath
ILF3 DUSP1 18490444 27898060 stimulant N/A OmniPath

Visualization










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