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GENE：ERCC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC1
FullNmae ERCC excision repair 1, endonuclease non-catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3433
EnsembleID ENSG00000012061
Uniprot P07992

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ERCC1 GO:0000014,GO:0000109,GO:0000110,GO:0000110,GO:0000720,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003684,GO:0003697,GO:0003697,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0006281,GO:0006289,GO:0006289,GO:0006303,GO:0006312,GO:0006312,GO:0006949,GO:0006979,GO:0007283,GO:0007584,GO:0008283,GO:0008340,GO:0008584,GO:0009650,GO:0009744,GO:0010165,GO:0032205,GO:0035166,GO:0035264,GO:0035902,GO:0036297,GO:0045190,GO:0046686,GO:0048009,GO:0048477,GO:0048568,GO:0060261,GO:0061819,GO:0070522,GO:0070522,GO:0070914,GO:0090399,GO:0090656,GO:1904431,GO:1905765,GO:1990599,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC1 hsa:2067 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
ERCC1 hsa:2067 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
ERCC1 hsa:2067 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERCC1 CDK7 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
ERCC1 MNAT1 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
ERCC1 XAB2 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
ERCC1 XPA 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
RPA2 ERCC1 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
ERCC1 MLH1 10882712 11900249 12648680 12947387 15703371 16612326 16697054 17036055 17884153 18157157 18406444 19473888 19595721 19596235 19596236 19686080 19805513 19809470 19847258 20478261 21376743 22101340 22257761 22373527 22743550 22824526 23085398 24050180 26192618 interaction type N/A ACSN
ERCC1 PMS2 10882712 11900249 12648680 12947387 15703371 16612326 16697054 17036055 17884153 18157157 18406444 19473888 19595721 19596235 19596236 19686080 19805513 19809470 19847258 20478261 21376743 22101340 22257761 22373527 22743550 22824526 23085398 24050180 26192618 interaction type N/A ACSN
ERCC1 SLX4 11900249 12648680 12947387 15703371 16697054 17884153 19473888 19595721 19596235 19596236 19686080 19809470 19847258 21376743 22101340 22257761 22373527 22743550 22824526 23085398 24050180 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR ERCC1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ERCC1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ERCC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ERCC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ERCC1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ERCC1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C ERCC1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ERCC1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERCC1 18971253 22159227 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ERCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KAT5 ERCC1 22159227 trascriptional regulation,stimulation inferred by curator TFlink
JUN ERCC1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 ERCC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 ERCC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000083D87 ERCC1 20371350 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 ERCC1 20371350 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 ERCC1 20371350 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000411672 ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F ERCC1 21572407 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 ERCC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 ERCC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 ERCC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E ERCC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 ERCC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D ERCC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 ERCC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C ERCC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ERCC1 25416803 25950430 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001D4A78 ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000009EA8F ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000C73C ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AD450 ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000419B5A ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E5ECC ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD6DC ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001F14FE ERCC1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERCC1 MSH2 25361965 interaction type N/A PTMCode2
MSH2 ERCC1 25361965 interaction type N/A PTMCode2
ERCC1 DDB1 25361965 interaction type N/A PTMCode2
DDB1 ERCC1 25361965 interaction type N/A PTMCode2
ERCC1 FEN1 25361965 interaction type N/A PTMCode2
FEN1 ERCC1 25361965 interaction type N/A PTMCode2
ERCC1 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 ERCC1 25361965 interaction type N/A PTMCode2
ERCC1 RAD52 25361965 interaction type N/A PTMCode2
RAD52 ERCC1 25361965 interaction type N/A PTMCode2
ERCC1 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L ERCC1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF12 ERCC1 25348397 N/A physical interaction ComPPI
TP53BP1 ERCC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
MKRN3 ERCC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBL7 ERCC1 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
VPS37B ERCC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TBP ERCC1 25348397 N/A physical interaction ComPPI
GTF2H1 ERCC1 25348397 N/A physical interaction ComPPI
RPA1 ERCC1 25348397 N/A physical interaction ComPPI
RPA2 ERCC1 25348397 N/A physical interaction ComPPI
RPA3 ERCC1 25348397 N/A physical interaction ComPPI
XPA ERCC1 11058119 14525934 16491090 24234451 25348397 25416956 7598728 8197174 9653453 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
RNF8 ERCC1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SPTA1 ERCC1 25348397 N/A physical interaction ComPPI
EGFR ERCC1 24234451 24780295 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy,proximity ligation assay ComPPI,IntAct
TAF6 ERCC1 25348397 N/A physical interaction ComPPI
POLR2A ERCC1 25348397 N/A physical interaction ComPPI
MDC1 ERCC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TAF7 ERCC1 25348397 N/A physical interaction ComPPI
TAF10 ERCC1 25348397 N/A physical interaction ComPPI
BRCA1 ERCC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
UHRF1 ERCC1 25348397 N/A physical interaction ComPPI
MUS81 ERCC1 25348397 N/A physical interaction ComPPI
USHBP1 ERCC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ERCC4 ERCC1 14525934 16338413 17289582 24234451 24780295 25348397 8197175 9722633 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ERCC1 SLX4 19596235 19596236 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
ERCC1 SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC1 FANCG 20518486 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ERCC1 MSH2 25348397 N/A physical interaction ComPPI
ERCC1 TRMT2B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ERCC1 SLX4IP 25348397 N/A physical interaction ComPPI
ERCC1 MAGIX 25348397 N/A physical interaction ComPPI
ERCC1 ACAT1 25348397 N/A physical interaction ComPPI
ERCC1 C15ORF40 25348397 N/A physical interaction ComPPI
ERCC1 TOPBP1 25348397 N/A physical interaction ComPPI
ERCC1 TWF2 25348397 N/A physical interaction ComPPI
ERCC1 APP 25348397 N/A physical interaction ComPPI
ERCC1 USP45 25348397 N/A physical interaction ComPPI
ERCC1 ZFC3H1 25348397 N/A physical interaction ComPPI
ERCC1 DCAF1 24234451 24412650 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
ERCC1 SNAI1 24234451 25314079 association chromatin immunoprecipitation assay IntAct
CREBBP ERCC1 24234451 25314079 association chromatin immunoprecipitation assay IntAct
CHRM5 ERCC1 24234451 28298427 physical association ubiquitin reconstruction IntAct
XPA ERCC1 11058119 16491090 17948053 19056823 25416956 26186194 27898060 7598728 7876167 8197174 8972858 9653453 stimulant N/A OmniPath

Visualization










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