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GENE：GRIK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRIK2
FullNmae glutamate ionotropic receptor kainate type subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4580
EnsembleID ENSG00000164418
Uniprot Q13002

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRIK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRIK2 GO:0000149,GO:0001662,GO:0005234,GO:0005886,GO:0005886,GO:0006874,GO:0007215,GO:0007268,GO:0015277,GO:0015277,GO:0019228,GO:0030165,GO:0031624,GO:0031625,GO:0032839,GO:0032983,GO:0034220,GO:0035235,GO:0035249,GO:0042734,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043524,GO:0043525,GO:0046328,GO:0048169,GO:0048172,GO:0050804,GO:0050804,GO:0050806,GO:0051402,GO:0051967,GO:0060079,GO:0060080,GO:0097110,GO:0097471,GO:0098686,GO:0098815,GO:0098839,GO:0098978,GO:0099171,GO:0099505,GO:0099507,GO:0120169,GO:1904315

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GRIK2 hsa:2898 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
GRIK2 hsa:2898 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DLG4 GRIK2 20005715 interaction type N/A PSP
GRIP1 GRIK2 20005715 interaction type N/A PSP
SDCBP GRIK2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR GRIK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GRIK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GRIK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 GRIK2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GRIK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 GRIK2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000032FC1A GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000032AE90 GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000939AF GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E5ECC GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002FF522 GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000002CF68 GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075C1E1 GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004E008F GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 GRIK2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC GRIK2 22135298 phosphorylation N/A PhosphoSite
PRKCA GRIK2 22135298 phosphorylation N/A PhosphoSite
GRIA1 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 GRIA1 25361965 interaction type N/A PTMCode2
DLG4 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 DLG4 25361965 interaction type N/A PTMCode2
PICK1 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 PICK1 25361965 interaction type N/A PTMCode2
DLG3 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 DLG3 25361965 interaction type N/A PTMCode2
GRIK5 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 GRIK5 25361965 interaction type N/A PTMCode2
SDCBP GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 SDCBP 25361965 interaction type N/A PTMCode2
GRIP1 GRIK2 25361965 interaction type N/A PTMCode2
GRIK2 GRIP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DLG4 GRIK2 11276111 11279111 11744724 12597860 14525934 25348397 27898060 9808460 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PICK1 GRIK2 12597860 14525934 18692513 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
GRID2 GRIK2 12573530 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HNRNPL GRIK2 25348397 N/A physical interaction ComPPI
CALCOCO1 GRIK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRIA2 GRIK2 25348397 N/A physical interaction ComPPI
SDCBP GRIK2 12597860 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
DLG1 GRIK2 11279111 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DLG3 GRIK2 12070168 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKN GRIK2 25316086 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GRIK5 GRIK2 14525934 25348397 9466455 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TRIM25 GRIK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GRIP1 GRIK2 25348397 N/A physical interaction ComPPI
GRIK2 GRIA1 10358037 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GRIK2 CDH2 12151522 14525934 N/A experimental interaction detection HPRD
GRIK2 CTNNB1 12151522 14525934 N/A experimental interaction detection HPRD
GRIK2 GRIK2 12597860 14525934 N/A experimental interaction detection HPRD
CASK GRIK2 12151522 14525934 N/A experimental interaction detection HPRD
GRIK4 GRIK2 12954862 14525934 8288598 N/A experimental interaction detection HPRD
CTNND1 GRIK2 12151522 14525934 N/A experimental interaction detection HPRD
PRKAA1 GRIK2 14525934 8094892 8163463 N/A experimental interaction detection HPRD
LIN7B GRIK2 12151522 14525934 N/A experimental interaction detection HPRD
GRIK2 KLHL24 17254796 27898060 N/A N/A OmniPath
PRKACA GRIK2 27898060 8094892 stimulant N/A OmniPath
PRKCA GRIK2 22522402 27898060 N/A N/A OmniPath
ATM GRIK2 27898060 8382377 N/A N/A OmniPath
PRKAA1 GRIK2 27898060 8094892 8163463 N/A N/A OmniPath

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