Gene Information gene info

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GENE：HLA-DMA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HLA-DMA
FullNmae major histocompatibility complex, class II, DM alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4934
EnsembleID ENSG00000204257
Uniprot P28067

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HLA-DMA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HLA-DMA GO:0002250,GO:0002503,GO:0002503,GO:0005515,GO:0005765,GO:0005765,GO:0005765,GO:0009986,GO:0016020,GO:0019886,GO:0023026,GO:0023026,GO:0031902,GO:0031902,GO:0042605,GO:0042613,GO:0042613,GO:0043231,GO:0050778,GO:0050870

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HLA-DMA hsa:3108 path:hsa04145 Phagosome - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05140 Leishmaniasis - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05152 Tuberculosis - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05164 Influenza A - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05310 Asthma - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05330 Allograft rejection - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
HLA-DMA hsa:3108 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HLA-DMA HLA-DRA 21131964 23180781 physical association surface plasmon resonance InnateDB
HLA-DMA HLA-DRB1 21131964 23180781 physical association surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HLA-DMA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CIITA HLA-DMA 7495736 9300700 trascriptional regulation,stimulation inferred by curator TFlink
RFX5 HLA-DMA 11258423 7495736 trascriptional regulation,stimulation inferred by curator TFlink
RFXANK HLA-DMA 11258423 trascriptional regulation,stimulation inferred by curator TFlink
RFXAP HLA-DMA 11258423 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
U2AF2 HLA-DMA 25348397 N/A physical interaction ComPPI
MBP HLA-DMA 21131964 24234451 25348397 association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CD74 HLA-DMA 21131964 24234451 25348397 association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
RUNX1 HLA-DMA 25348397 N/A physical interaction ComPPI
HLA-DRB1 HLA-DMA 21131964 23260142 24234451 25348397 association,physical association fluorescence polarization spectroscopy,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,IntAct
HLA-DRA HLA-DMA 21131964 23260142 24234451 25348397 association,physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
HLA-DMB HLA-DMA 11606727 21131964 23222639 24234451 25348397 27898060 8139690 8574855 9768757 association,physical association anti tag coimmunoprecipitation,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction ComPPI,IntAct,OmniPath
B3GAT1 HLA-DMA 25348397 N/A physical interaction ComPPI
HLA-DMA HLA-DOA 23222639 24234451 association,physical association anti tag coimmunoprecipitation,molecular sieving,x-ray crystallography IntAct
HLA-DMA HLA-DOB 23222639 24234451 association,physical association anti tag coimmunoprecipitation,molecular sieving,x-ray crystallography IntAct
HLA-DMA MEP1B 24234451 27180358 physical association ubiquitin reconstruction IntAct

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