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GENE：NOTCH3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOTCH3
FullNmae notch receptor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7883
EnsembleID ENSG00000074181
Uniprot Q9UM47

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOTCH3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NOTCH3 GO:0000122,GO:0000139,GO:0005509,GO:0005515,GO:0005576,GO:0005654,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0007219,GO:0007411,GO:0009986,GO:0014016,GO:0019899,GO:0030900,GO:0038023,GO:0042802,GO:0043235,GO:0043235,GO:0045296,GO:0045665,GO:0045944,GO:0048661,GO:0048663,GO:0048844,GO:0072104

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NOTCH3 hsa:4854 path:hsa01522 Endocrine resistance - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa05200 Pathways in cancer - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
NOTCH3 hsa:4854 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTCF NOTCH3 23180781 24984200 physical association anti tag coimmunoprecipitation InnateDB
CTCFL NOTCH3 23180781 24984200 physical association anti tag coimmunoprecipitation InnateDB
JAG2 NOTCH3 10958687 11006133 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
ADAM10 NOTCH3 12651094 23331499 stimulation N/A SignaLink,SignaLink
NOTCH3 NOTCH1 10433920 11404076 21071413 23331499 interaction type N/A SignaLink,SignaLink
DTX4 NOTCH3 10531053 23331499 stimulation N/A SignaLink
LTC4S NOTCH3 11101851 23331499 stimulation N/A SignaLink
NOTCH3 RBPJ 11404076 23331499 stimulation N/A SignaLink
MAML2 NOTCH3 12370315 23331499 stimulation N/A SignaLink
MAML3 NOTCH3 12370315 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
JAG2 NOTCH3 20005715 interaction type N/A PSP
NCK1 NOTCH3 20005715 interaction type N/A PSP,SignaLink
JAG2 NOTCH3 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NOTCH3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 NOTCH3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NOTCH3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 NOTCH3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NOTCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MSX1 NOTCH3 18201699 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000016FD1A NOTCH3 21551231 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000034B6F5 NOTCH3 19723635 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000034B6F5 NOTCH3 18927107 19723635 22743998 25416803 25607234 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS000016FD1A NOTCH3 21551231 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 NOTCH3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE NOTCH3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001919B0 NOTCH3 25416803 27035429 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000204177 NOTCH3 25416803 27887917 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003575B NOTCH3 25416803 25622783 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
JAG1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 JAG1 25361965 interaction type N/A PTMCode2
NOTCH3 KAT2B 25361965 interaction type N/A PTMCode2
KAT2B NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 NOTCH1 25361965 interaction type N/A PTMCode2
NOTCH1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 MAML1 25361965 interaction type N/A PTMCode2
MAML1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 JAG2 25361965 interaction type N/A PTMCode2
JAG2 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 RBPJ 25361965 interaction type N/A PTMCode2
RBPJ NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 DLL1 25361965 interaction type N/A PTMCode2
DLL1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 POFUT1 25361965 interaction type N/A PTMCode2
POFUT1 NOTCH3 25361965 interaction type N/A PTMCode2
NOTCH3 MAML2 25361965 interaction type N/A PTMCode2
MAML2 NOTCH3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 NOTCH3 25348397 N/A physical interaction ComPPI
SNW1 NOTCH3 11404076 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SORBS3 NOTCH3 25348397 N/A physical interaction ComPPI
RABGGTB NOTCH3 25348397 N/A physical interaction ComPPI
ZNF223 NOTCH3 25348397 N/A physical interaction ComPPI
PRR20D NOTCH3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EGLN3 NOTCH3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CBL NOTCH3 25348397 N/A physical interaction ComPPI
MAML1 NOTCH3 11101851 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NOTCH1 NOTCH3 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DLL1 NOTCH3 11006133 12482954 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCK1 NOTCH3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NEDD9 NOTCH3 25348397 N/A physical interaction ComPPI
KAT2B NOTCH3 11404076 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
GSK3B NOTCH3 25348397 N/A physical interaction ComPPI
NTRK1 NOTCH3 25348397 N/A physical interaction ComPPI
IFNGR1 NOTCH3 25348397 N/A physical interaction ComPPI
CDH1 NOTCH3 25348397 N/A physical interaction ComPPI
WWP2 NOTCH3 25348397 N/A physical interaction ComPPI
PSMA1 NOTCH3 25348397 N/A physical interaction ComPPI
MYC NOTCH3 25348397 N/A physical interaction ComPPI
LRP1 NOTCH3 20472562 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
HNRNPL NOTCH3 25348397 N/A physical interaction ComPPI
TNNT2 NOTCH3 25348397 N/A physical interaction ComPPI
CBFA2T2 NOTCH3 25348397 N/A physical interaction ComPPI
TPT1 NOTCH3 25348397 N/A physical interaction ComPPI
PSEN2 NOTCH3 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RET NOTCH3 25348397 N/A physical interaction ComPPI
STRAP NOTCH3 25348397 N/A physical interaction ComPPI
JAG2 NOTCH3 11006133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAML2 NOTCH3 12370315 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAML3 NOTCH3 12370315 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CHUK NOTCH3 14525934 17289033 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HIF1AN NOTCH3 24234451 25348397 26972000 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBLN1 NOTCH3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPIA NOTCH3 25348397 N/A physical interaction ComPPI
CRIP2 NOTCH3 25348397 N/A physical interaction ComPPI
NOTCH3 PSEN1 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOTCH3 RBPJ 11404076 14525934 24234451 25348397 25609649 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NOTCH3 JAG1 12482954 14525934 14714274 22487239 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
NOTCH3 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOTCH3 PTCRA 25348397 N/A physical interaction ComPPI
NOTCH3 EGFL7 25348397 N/A physical interaction ComPPI
NOTCH3 MPPED2 25348397 N/A physical interaction ComPPI
NOTCH3 GGT6 25348397 N/A physical interaction ComPPI
NOTCH3 SPTLC2 25348397 N/A physical interaction ComPPI
NOTCH3 XKR8 25348397 N/A physical interaction ComPPI
NOTCH3 SNX19 25348397 N/A physical interaction ComPPI
NOTCH3 CNTD1 25348397 N/A physical interaction ComPPI
NOTCH3 WDR25 25348397 N/A physical interaction ComPPI
NOTCH3 SCGB3A1 25348397 N/A physical interaction ComPPI
NOTCH3 CPNE6 25348397 N/A physical interaction ComPPI
NOTCH3 BAG2 25348397 N/A physical interaction ComPPI
NOTCH3 SLC39A1 25348397 N/A physical interaction ComPPI
NOTCH3 C1QL1 25348397 N/A physical interaction ComPPI
NOTCH3 TMEM108 25348397 N/A physical interaction ComPPI
NOTCH3 RMI2 25348397 N/A physical interaction ComPPI
NOTCH3 BTF3L4 25348397 N/A physical interaction ComPPI
NOTCH3 ANKRD44 25348397 N/A physical interaction ComPPI
NOTCH3 TSPAN3 25348397 N/A physical interaction ComPPI
NOTCH3 ZFP41 25348397 N/A physical interaction ComPPI
NOTCH3 DLK2 25348397 N/A physical interaction ComPPI
NOTCH3 ADAM33 25348397 N/A physical interaction ComPPI
NOTCH3 ADAM32 25348397 N/A physical interaction ComPPI
NOTCH3 DNAJC10 25348397 N/A physical interaction ComPPI
NOTCH3 LRRIQ1 25348397 N/A physical interaction ComPPI
NOTCH3 MANSC1 25348397 N/A physical interaction ComPPI
NOTCH3 DEFA1 25348397 N/A physical interaction ComPPI
NOTCH3 ABCG8 25348397 N/A physical interaction ComPPI
NOTCH3 SLC20A1 25348397 N/A physical interaction ComPPI
NOTCH3 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NOTCH3 ANKRD28 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
NOTCH3 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
NOTCH3 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
ZNF224 NOTCH3 25348397 N/A physical interaction ComPPI
NEU2 NOTCH3 25348397 N/A physical interaction ComPPI
ELF3 NOTCH3 24234451 26977885 association chromatin immunoprecipitation assay IntAct
NOTCH3 NOTCH3 24234451 26051713 N/A cosedimentation in solution,x-ray crystallography IntAct
JAG2 NOTCH3 10958687 1100613 11006133 27898060 inhibition,stimulant N/A OmniPath
MAML1 NOTCH3 11101851 27898060 stimulant N/A OmniPath
NOTCH3 RBPJ 11404076 25356737 25609649 26186194 27898060 stimulant N/A OmniPath
DLL1 NOTCH3 11006133 12482954 27898060 stimulant N/A OmniPath
NOTCH3 NOTCH1 1043392 11404076 27898060 N/A N/A OmniPath
JAG1 NOTCH3 11006133 12482954 14714274 18660822 22487239 27898060 inhibition,stimulant N/A OmniPath
ADAM10 NOTCH3 12651094 27898060 stimulant N/A OmniPath
DLL4 NOTCH3 18182388 27898060 stimulant N/A OmniPath
MAML3 NOTCH3 12370315 27898060 stimulant N/A OmniPath
MAML2 NOTCH3 12370315 27898060 stimulant N/A OmniPath
THBS2 NOTCH3 19147503 27898060 N/A N/A OmniPath

Visualization










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