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GENE：PIAS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIAS1
FullNmae protein inhibitor of activated STAT 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2752
EnsembleID ENSG00000033800
Uniprot O75925

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIAS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIAS1 GO:0000082,GO:0000122,GO:0000976,GO:0003712,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007259,GO:0007283,GO:0008270,GO:0008542,GO:0016605,GO:0016607,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0016925,GO:0019789,GO:0019789,GO:0019899,GO:0019904,GO:0031625,GO:0032436,GO:0033235,GO:0034399,GO:0042127,GO:0043066,GO:0045444,GO:0045893,GO:0051152,GO:0061665,GO:0061665,GO:0065004,GO:0140297,GO:1904377

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIAS1 hsa:8554 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
PIAS1 hsa:8554 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIAS1 hsa:8554 path:hsa05160 Hepatitis C - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIAS1 PPARG 16127449 20711444 26192618 interaction type N/A ACSN
PIAS1 KLF8 15117942 16127449 19218564 20711444 26192618 interaction type N/A ACSN
UBE2I PIAS1 12764129 23180781 physical association sumoylation reaction InnateDB
PIAS1 STAT1 10805787 12171910 12855578 14699505 18031232 18988627 19136629 23180781 23331499 29145629 9724754 stimulation,physical association anti tag coimmunoprecipitation,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
MBD1 PIAS1 19074829 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIAS1 PRMT1 19136629 23180781 methylation reaction,physical association anti tag coimmunoprecipitation,pull down,enzymatic study InnateDB
PIAS1 CXCL9 19136629 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIAS1 CXCL10 19136629 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIAS1 PRMT6 19136629 23180781 methylation reaction enzymatic study InnateDB
PIAS1 LYL1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
CEBPE PIAS1 15588942 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
PIAS1 SUMO1 10805787 12855578 18031232 29145629 physical association inferred by curator Reactome
PIAS1 SMAD4 15028714 15231748 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AXIN1 PIAS1 20005715 interaction type N/A PSP
SNIP1 PIAS1 20005715 interaction type N/A PSP
SUFU PIAS1 20005715 interaction type N/A PSP
SNIP1 PIAS1 20005715 N/A N/A SignaLink
SUFU PIAS1 20005715 N/A N/A SignaLink
AXIN1 PIAS1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PIAS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PIAS1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PIAS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PIAS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 PIAS1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PIAS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F0F49 PIAS1 20065103 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 PIAS1 20065103 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000427B68 PIAS1 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PIAS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000031F6C2 PIAS1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 PIAS1 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 PIAS1 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D PIAS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000157F5 PIAS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000171FEC PIAS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA PIAS1 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 PIAS1 22135298 phosphorylation N/A PhosphoSite
PRKAA1 PIAS1 22135298 phosphorylation N/A PhosphoSite
MAPKAPK2 PIAS1 22135298 phosphorylation N/A PhosphoSite
GSK3B PIAS1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIAS2 PIAS1 11877418 14525934 24234451 25241761 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
UBE2I PIAS1 11583632 11867732 12177000 12356736 12764129 14525934 14609633 15561718 16148010 19692572 19965618 20936779 22661230 24234451 25348397 27898060 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
CBSL PIAS1 25348397 N/A physical interaction ComPPI
DDX21 PIAS1 14525934 25348397 27898060 9177271 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SGTA PIAS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1CC PIAS1 25348397 N/A physical interaction ComPPI
SKIL PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
STAT1 PIAS1 10805787 12855578 14525934 24234451 25241761 25348397 9724754 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
TP53BP1 PIAS1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
ATXN1 PIAS1 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
NR5A1 PIAS1 14525934 15192080 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD4 PIAS1 14525934 15028714 15231748 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
SNIP1 PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
ARID3A PIAS1 19214191 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD1 PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SIAH2 PIAS1 25348397 N/A physical interaction ComPPI
TBP PIAS1 14525934 16522640 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SMAD7 PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAML1 PIAS1 25348397 N/A physical interaction ComPPI
NFATC1 PIAS1 25348397 N/A physical interaction ComPPI
FLI1 PIAS1 25348397 N/A physical interaction ComPPI
JUN PIAS1 11867732 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR PIAS1 11877418 12177000 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CREBBP PIAS1 14525934 15957955 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUMO1 PIAS1 11583632 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NCOA3 PIAS1 25348397 N/A physical interaction ComPPI
EP300 PIAS1 25348397 N/A physical interaction ComPPI
HIF1A PIAS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 NR2F2 14525934 15611122 15666827 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
PIAS1 ZNF76 14525934 15280358 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIAS1 ELK3 14525934 15580297 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PIAS1 CEBPE 14525934 15588942 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIAS1 NR3C2 14500761 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PIAS1 SP3 12356736 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIAS1 TP73 14525934 15572666 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PIAS1 DNM1 14525934 15123615 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIAS1 DNMT3A 14525934 14752048 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIAS1 AXIN1 12223491 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIAS1 PIAS4 11877418 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIAS1 DCLRE1A 15572677 25348397 27898060 N/A two hybrid,physical interaction,in vitro ComPPI,OmniPath
PIAS1 GATA4 14525934 15337742 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PIAS1 SATB2 14525934 14701874 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIAS1 CASP8 14525934 15782135 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIAS1 CEBPA 14525934 15588942 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIAS1 ESR2 11117529 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD
PIAS1 PGR 11117529 14525934 17053081 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
PIAS1 MSX1 14525934 16600910 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIAS1 NIN 14525934 16154161 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIAS1 GRM8 14525934 16144832 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PIAS1 MBD1 14525934 17066076 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PIAS1 CHUK 14525934 17540171 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIAS1 PTPN1 14525934 17159996 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PIAS1 ESR1 14525934 15666801 25348397 N/A two hybrid,physical interaction,biochemical,two hybrid ComPPI,HPRD
PIAS1 RELA 14525934 15657437 17540171 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PIAS1 MDM2 12393906 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PIAS1 STAB2 25348397 N/A physical interaction ComPPI
PIAS1 TP53 11583632 11788578 11867732 14525934 15133049 24234451 25241761 25348397 physical association experimental interaction detection,pull down,physical interaction,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
PIAS1 MX1 25348397 N/A physical interaction ComPPI
PIAS1 SUMO2 25348397 N/A physical interaction ComPPI
PIAS1 SIAH1 25348397 N/A physical interaction ComPPI
PIAS1 AKT1 25348397 N/A physical interaction ComPPI
PIAS1 ZMIZ2 25348397 N/A physical interaction ComPPI
PIAS1 BRCA1 24234451 25348397 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PIAS1 CREB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS1 MITF 25348397 N/A physical interaction ComPPI
PIAS1 NCOR1 25348397 N/A physical interaction ComPPI
PIAS1 PPARG 25348397 N/A physical interaction ComPPI
PIAS1 TRIM27 25348397 N/A physical interaction ComPPI
PIAS1 HIC1 25348397 N/A physical interaction ComPPI
PIAS1 DDX5 25348397 N/A physical interaction ComPPI
PIAS1 SATB1 18408014 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 DNMT3B 25348397 N/A physical interaction ComPPI
PIAS1 RBBP6 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 SAFB 25348397 N/A physical interaction ComPPI
PIAS1 PPP1CA 22321011 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 MDC1 25348397 N/A physical interaction ComPPI
PIAS1 PRDM1 22555612 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 PML 25348397 N/A physical interaction ComPPI
PIAS1 ATXN7 25348397 N/A physical interaction ComPPI
PIAS1 SRSF1 25348397 N/A physical interaction ComPPI
PIAS1 CSNK2A1 25348397 N/A physical interaction ComPPI
PIAS1 CASP8AP2 21338522 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
PIAS1 MYB 21338522 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 SERBP1 25348397 N/A physical interaction ComPPI
PIAS1 ZMYND11 25348397 N/A physical interaction ComPPI
PIAS1 RAD54L2 25348397 N/A physical interaction ComPPI
PIAS1 PLAG1 25348397 N/A physical interaction ComPPI
PIAS1 NR1H3 25348397 N/A physical interaction ComPPI
PIAS1 NR1H2 25348397 N/A physical interaction ComPPI
PIAS1 PPARGC1B 25348397 N/A physical interaction ComPPI
PIAS1 PPARGC1A 25348397 N/A physical interaction ComPPI
PIAS1 BARD1 25348397 N/A physical interaction ComPPI
PIAS1 PAXIP1 25348397 N/A physical interaction ComPPI
PIAS1 HTT 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
PIAS1 YWHAZ 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIAS1 SUMO3 25348397 N/A physical interaction ComPPI
PIAS1 SEM1 25348397 N/A physical interaction ComPPI
PIAS1 CBS 25348397 N/A physical interaction ComPPI
PIAS1 L3MBTL2 25348397 N/A physical interaction ComPPI
PIAS1 CEP250 25348397 N/A physical interaction ComPPI
PIAS1 TRIM63 25348397 N/A physical interaction ComPPI
PIAS1 TRIM55 25348397 N/A physical interaction ComPPI
PIAS1 ZNF451 25348397 N/A physical interaction ComPPI
PIAS1 FOXA1 25348397 N/A physical interaction ComPPI
PIAS1 ID1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 KLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 COA8 25348397 N/A physical interaction ComPPI
PIAS1 FRAT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 ERP44 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 VPS16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 PTK2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PIAS1 TERF2 24234451 25348397 26450775 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIAS1 TRIM5 25348397 N/A physical interaction ComPPI
PIAS1 HECTD2 25348397 N/A physical interaction ComPPI
PIAS1 GSK3B 25348397 N/A physical interaction ComPPI
PIAS1 PSME3 25348397 N/A physical interaction ComPPI
PIAS1 TRIM35 25348397 N/A physical interaction ComPPI
PIAS1 GTF2IRD1 24234451 25348397 26275350 physical association two hybrid,physical interaction ComPPI,IntAct
PIAS1 NR0B2 25348397 N/A physical interaction ComPPI
PIAS1 FANCI 25348397 N/A physical interaction ComPPI
PIAS1 FANCD2 25348397 N/A physical interaction ComPPI
PIAS1 NEDD8 18274552 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PIAS1 PASK 21418524 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PIAS1 SETX 24234451 24244371 25348397 physical association two hybrid ComPPI,IntAct
PIAS1 SUMO1P1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
SUFU PIAS1 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PRPF40A PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SOX2 PIAS1 25348397 N/A physical interaction ComPPI
SEM1 PIAS1 25348397 N/A physical interaction ComPPI
CSRP2 PIAS1 11672422 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GLUL PIAS1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS1 PIAS1 14525934 14611647 N/A two hybrid HPRD
MAPKAPK2 PIAS1 23202365 27898060 stimulant N/A OmniPath
CHUK PIAS1 17540171 23032264 27898060 N/A N/A OmniPath
PRMT6 PIAS1 19136629 27898060 N/A N/A OmniPath
PIAS1 STAT1 10805787 11257227 11709556 12171910 12855578 14699505 17371985 18566411 19136629 23663276 25241761 27898060 9724754 inhibition,stimulant N/A OmniPath
STAT1 PIAS1 10805787 11257227 12171910 12855578 14699505 17371985 18566411 19136629 25241761 27898060 9724754 N/A N/A OmniPath
PIAS1 PRMT1 19136629 27898060 N/A N/A OmniPath
PRMT1 PIAS1 19136629 27898060 N/A N/A OmniPath
PIAS1 NR5A1 15192080 27898060 N/A N/A OmniPath
PIAS1 TP53BP1 20016603 27898060 stimulant N/A OmniPath
PIAS1 RPA2 20016603 27898060 stimulant N/A OmniPath
PIAS1 PRDM1 22555612 27898060 stimulant N/A OmniPath
PIAS1 SOX9 16554309 27898060 stimulant N/A OmniPath
MBD1 PIAS1 17066076 19074829 27898060 N/A N/A OmniPath
CSNK2A1 PIAS1 19217413 24174529 27898060 stimulant N/A OmniPath
PIAS1 SMAD4 15028714 15231748 1523175 21988832 27898060 stimulant N/A OmniPath
SRF PIAS1 12764129 27898060 N/A N/A OmniPath
PIAS1 DDX5 17369852 27898060 inhibition,stimulant N/A OmniPath
PIAS1 FHL1 17509614 27898060 inhibition N/A OmniPath
PIAS1 CEBPE 15588942 27898060 N/A N/A OmniPath
CEBPE PIAS1 15588942 27898060 N/A N/A OmniPath
PIAS1 SATB2 14701874 27898060 N/A N/A OmniPath

Visualization










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