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GENE：RORA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RORA
FullNmae RAR related orphan receptor A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10258
EnsembleID ENSG00000069667
Uniprot P35398

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RORA pyroptosis 37844792 In conclusion, HOTAIR competitively bound to miR-17-5p, relieving its inhibition of RORA transcription and leading to increased RORA expression and suppressed cardiomyocyte pyroptosis in HF models. retulator signature
RORA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RORA autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RORA GO:0000785,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0001221,GO:0001222,GO:0001223,GO:0001525,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006357,GO:0006805,GO:0006809,GO:0008013,GO:0008142,GO:0008142,GO:0008270,GO:0008589,GO:0010575,GO:0010906,GO:0019218,GO:0021702,GO:0021930,GO:0030522,GO:0032922,GO:0036315,GO:0036315,GO:0042632,GO:0042692,GO:0042753,GO:0043030,GO:0043124,GO:0043565,GO:0045599,GO:0045893,GO:0045944,GO:0046068,GO:0050728,GO:0050728,GO:0070328,GO:0071347,GO:0071356,GO:0071456,GO:0072539,GO:0098531

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RORA hsa:6095 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
RORA hsa:6095 path:hsa04710 Circadian rhythm - Homo sapiens (human)
RORA hsa:6095 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
RORA hsa:6095 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RORA PRDM7 15604093 23180781 physical association two hybrid InnateDB
RORA MAP4 15604093 23180781 physical association two hybrid InnateDB
RORA PNRC2 15604093 23180781 physical association two hybrid InnateDB
RORA COPS5 15604093 23180781 physical association two hybrid InnateDB
RORA PNRC1 15604093 23180781 physical association two hybrid InnateDB
RORA SRC 15604093 23180781 physical association two hybrid InnateDB
RORA PSMC5 15604093 23180781 physical association two hybrid InnateDB
RORA PROX1 15604093 23180781 physical association two hybrid InnateDB
RORA LSP1 15604093 23180781 physical association two hybrid InnateDB
RORA FOXP3 18354202 23180781 physical association two hybrid InnateDB
RORA NME1 23180781 8858107 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR RORA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RORA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RORA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RORA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 RORA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RORA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RORA 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RORA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A RORA 14742449 trascriptional regulation,stimulation inferred by curator TFlink
SP1 RORA 14742449 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 RORA 14742449 trascriptional regulation,stimulation inferred by curator TFlink
SP3 RORA 14742449 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 RORA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 RORA 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000600E6 RORA 17242205 20371350 21572407 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00001270D3 RORA 20371350 21572407 23716591 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002FC5B0 RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002AB575 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 RORA 19536157 23313552 23706177 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003808EC RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC RORA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001E3523 RORA 24500708 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000007340 RORA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF RORA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD RORA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 RORA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC RORA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000024B619 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000043F369 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000031F6C2 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000028C188 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 RORA 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C RORA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 RORA 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 RORA 19536157 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000003575B RORA 19536157 22927820 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000015A0D9 RORA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000210075 RORA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF RORA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 RORA 23313552 23706177 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002198F3 RORA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008931A RORA 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002F5FEE RORA 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000006372A RORA 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000016FD1B RORA 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000039607D RORA 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA RORA 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PNRC2 RORA 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EZH2 RORA 25348397 N/A physical interaction ComPPI
MYOD1 RORA 14525934 25348397 9862959 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCOA1 RORA 20203100 24234451 25348397 N/A physical interaction,amplified luminescent proximity homogeneous assay ComPPI,IntAct
EP300 RORA 14525934 25348397 9862959 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
COPS5 RORA 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CEBPB RORA 25348397 N/A physical interaction ComPPI
MED1 RORA 10478845 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
RUVBL1 RORA 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
CSNK1E RORA 25348397 N/A physical interaction ComPPI
NME1 RORA 14525934 25348397 8858107 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PSMC5 RORA 14525934 16189514 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NCOA2 RORA 10478845 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
NSD1 RORA 25348397 N/A physical interaction ComPPI
NR0B1 RORA 14525934 16713569 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PNRC1 RORA 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PROX1 RORA 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
LRIF1 RORA 25348397 N/A physical interaction ComPPI
PTBP1 RORA 23208419 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DDB1 RORA 25348397 N/A physical interaction ComPPI
RORA SMARCD3 14525934 14701856 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RORA ZXDC 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RORA NME2 14525934 25348397 8858107 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
RORA LMO3 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
RORA DCAF1 25348397 N/A physical interaction ComPPI
RORA GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RORA BHLHE41 25348397 N/A physical interaction ComPPI
RORA FOXP3 18354202 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
RORA RORA 14525934 7935491 N/A experimental interaction detection HPRD
HR RORA 12215540 27898060 N/A N/A OmniPath
RORA SRC 15604093 27898060 N/A N/A OmniPath
PRKCA RORA 20122401 27898060 N/A N/A OmniPath
RORA ARNTL 18454201 18662546 27898060 inhibition,stimulant N/A OmniPath
SUMO1 RORA 19041634 27898060 stimulant N/A OmniPath
MAPK1 RORA 17512500 27898060 inhibition N/A OmniPath

Visualization










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