Gene Information gene info

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GENE：TLR6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR6
FullNmae toll like receptor 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16711
EnsembleID ENSG00000174130
Uniprot Q9Y2C9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR6 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLR6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TLR6 GO:0001540,GO:0001774,GO:0002224,GO:0002755,GO:0002755,GO:0004888,GO:0005102,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0007165,GO:0007250,GO:0010628,GO:0030670,GO:0032717,GO:0032731,GO:0032755,GO:0034136,GO:0035355,GO:0035355,GO:0035663,GO:0035663,GO:0035666,GO:0038023,GO:0038124,GO:0042496,GO:0042742,GO:0042802,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0043507,GO:0045087,GO:0045121,GO:0045429,GO:0046209,GO:0046982,GO:0050135,GO:0051092,GO:0061809,GO:0071723,GO:0071723,GO:0071726,GO:0071726,GO:0140052,GO:0140052,GO:1900017,GO:1900227,GO:1903428,GO:1904646,GO:1904646,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR6 hsa:10333 path:hsa04145 Phagosome - Homo sapiens (human)
TLR6 hsa:10333 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR6 hsa:10333 path:hsa05132 Salmonella infection - Homo sapiens (human)
TLR6 hsa:10333 path:hsa05142 Chagas disease - Homo sapiens (human)
TLR6 hsa:10333 path:hsa05152 Tuberculosis - Homo sapiens (human)
TLR6 hsa:10333 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR6 BTK 12724322 23180781 physical association two hybrid InnateDB
TRAP1 TLR6 16482509 23180781 physical association two hybrid InnateDB
TLR6 MYD88 19717524 23180781 physical association affinity chromatography technology,two hybrid InnateDB
CD36 TLR6 20037584 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR6 TP53 21483755 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 TLR6 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 TLR6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 TLR6 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TLR6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLR6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TLR6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TLR6 18159247 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002AB575 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002DD349 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 TLR6 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BTK TLR6 12724322 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CD36 TLR6 20037584 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TRAP1 TLR6 14525934 16482509 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TLR2 TLR6 12077222 14525934 23155421 24234451 25348397 physical association cosedimentation in solution,experimental interaction detection,fluorescent resonance energy transfer,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR4 TLR6 20037584 24234451 25348397 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
TLR1 TLR6 23155421 24234451 25348397 physical association physical interaction,tox-r dimerization assay ComPPI,IntAct
TLR6 IQUB 25348397 N/A physical interaction ComPPI
TLR6 TLR10 23155421 24234451 25348397 physical association tox-r dimerization assay ComPPI,IntAct
SIGLEC5 TLR6 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR6 TLR6 23155421 24234451 physical association cosedimentation in solution,fluorescence technology,tox-r dimerization assay IntAct
MYD88 TLR6 19717524 27898060 N/A N/A OmniPath
TLR2 TLR6 12077222 16455995 27898060 N/A N/A OmniPath
TLR6 TLR2 12077222 16455995 27898060 N/A N/A OmniPath
BTK TLR6 12724322 27898060 N/A N/A OmniPath
TLR6 TRAP1 16482509 27898060 N/A N/A OmniPath
TLR1 TLR6 16455995 27898060 N/A N/A OmniPath
ZG16B TLR6 20802527 27898060 N/A N/A OmniPath

Visualization










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