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GENE：XRCC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XRCC1
FullNmae X-ray repair cross complementing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12828
EnsembleID ENSG00000073050
Uniprot P18887

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XRCC1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
XRCC1 GO:0000012,GO:0000781,GO:0000785,GO:0001666,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006284,GO:0006284,GO:0006303,GO:0009410,GO:0010033,GO:0010836,GO:0010836,GO:0019899,GO:0021587,GO:0021766,GO:0032356,GO:0033194,GO:0050882,GO:0061819,GO:0070522,GO:0072572,GO:0090734,GO:0160002,GO:1903518,GO:1903518,GO:1904877,GO:1905765,GO:1990414,GO:1990599

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XRCC1 hsa:7515 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA XRCC1 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
RPA2 XRCC1 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLE 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLK 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
PARP1 XRCC1 10858306 11163244 11283614 11900249 11948190 12032095 12202749 12637553 12648680 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17884153 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19362533 19364882 19490890 19546231 19748837 19809470 19847258 20027199 20056333 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
WRN XRCC1 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLB 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 PARP2 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 26192618 8264637 8978692 interaction type N/A ACSN
CHEK2 XRCC1 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 XRCC1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 XRCC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 XRCC1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 XRCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF XRCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 XRCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 XRCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 XRCC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 XRCC1 19031698 trascriptional regulation,stimulation inferred by curator TFlink
PLAG1 XRCC1 16596326 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 XRCC1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001A7F58 XRCC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 XRCC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 XRCC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CF056 XRCC1 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001E0AEA XRCC1 25416803 26893725 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 XRCC1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CHEK2 XRCC1 22135298 phosphorylation N/A PhosphoSite
PRKDC XRCC1 22135298 phosphorylation N/A PhosphoSite
CSNK2A2 XRCC1 22135298 phosphorylation N/A PhosphoSite
CDK2 XRCC1 22135298 phosphorylation N/A PhosphoSite
XRCC1 CSNK2A1 25361965 interaction type N/A PTMCode2
XRCC1 TP53 25361965 interaction type N/A PTMCode2
TP53 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 TIPARP 25361965 interaction type N/A PTMCode2
TIPARP XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 APLF 25361965 interaction type N/A PTMCode2
APLF XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 PNKP 25361965 interaction type N/A PTMCode2
PNKP XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 TDP1 25361965 interaction type N/A PTMCode2
TDP1 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 NEIL1 25361965 interaction type N/A PTMCode2
NEIL1 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 BRCA1 25361965 interaction type N/A PTMCode2
BRCA1 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 LIG3 25361965 interaction type N/A PTMCode2
LIG3 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 PCNA 25361965 interaction type N/A PTMCode2
PCNA XRCC1 25361965 interaction type N/A PTMCode2
APEX1 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 APEX1 25361965 interaction type N/A PTMCode2
XRCC1 XRCC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I XRCC1 25348397 N/A physical interaction ComPPI
GCC1 XRCC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA XRCC1 14525934 15107487 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
POLB XRCC1 11467963 14525934 15520167 24234451 25348397 26496610 8978692 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TP53BP1 XRCC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
LMNA XRCC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FOXB1 XRCC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RAN XRCC1 25348397 N/A physical interaction ComPPI
PPFIA1 XRCC1 25348397 N/A physical interaction ComPPI
H2BC4 XRCC1 25348397 N/A physical interaction ComPPI
AIM2 XRCC1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
S100A16 XRCC1 25348397 N/A physical interaction ComPPI
APLF XRCC1 14525934 17353262 17396150 23178593 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,far western blotting,filter binding,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
POLI XRCC1 18923427 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NF2 XRCC1 25348397 N/A physical interaction ComPPI
PRKDC XRCC1 25348397 N/A physical interaction ComPPI
PNKP XRCC1 11163244 14525934 17353931 19155274 21637298 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RBM4 XRCC1 25348397 N/A physical interaction ComPPI
HSP90AA1 XRCC1 25348397 N/A physical interaction ComPPI
NTRK1 XRCC1 25348397 N/A physical interaction ComPPI
PARP1 XRCC1 14500814 14525934 15044383 15555565 18971944 24234451 24778456 25348397 9584196 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
XRCC1 LIG3 11163244 14525934 17353931 24234451 25348397 26496610 8264637 9136882 9705932 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
XRCC1 OGG1 12933815 14525934 16713569 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
XRCC1 APTX 14525934 15044383 15367657 15380105 15555565 16713569 16964241 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
XRCC1 PARP2 11948190 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
XRCC1 NEIL1 14525934 15260972 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XRCC1 BRCA1 11352725 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
XRCC1 CSNK2A1 14525934 15066279 15367657 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
XRCC1 TP53 15044383 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 APEX1 11707423 14525934 19934257 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
XRCC1 CHD1L 25348397 N/A physical interaction ComPPI
XRCC1 NCAPG 25348397 N/A physical interaction ComPPI
XRCC1 POLK 25348397 N/A physical interaction ComPPI
XRCC1 POLD1 25348397 N/A physical interaction ComPPI
XRCC1 RNF146 25348397 N/A physical interaction ComPPI
XRCC1 XPO1 25348397 N/A physical interaction ComPPI
XRCC1 CAND1 25348397 N/A physical interaction ComPPI
XRCC1 PPT1 25348397 N/A physical interaction ComPPI
XRCC1 SEPTIN11 25348397 N/A physical interaction ComPPI
XRCC1 UBAP2L 25348397 N/A physical interaction ComPPI
XRCC1 SEC22B 25348397 N/A physical interaction ComPPI
XRCC1 MRPL12 25348397 N/A physical interaction ComPPI
XRCC1 SLC25A10 25348397 N/A physical interaction ComPPI
XRCC1 TIMELESS 25348397 N/A physical interaction ComPPI
XRCC1 RPA3 25348397 N/A physical interaction ComPPI
XRCC1 RPA2 25348397 N/A physical interaction ComPPI
XRCC1 CUL7 25348397 N/A physical interaction ComPPI
XRCC1 EED 25348397 N/A physical interaction ComPPI
XRCC1 RNF166 25348397 N/A physical interaction ComPPI
XRCC1 H2BC1 25348397 N/A physical interaction ComPPI
XRCC1 H2BC11 25348397 N/A physical interaction ComPPI
XRCC1 C1QBP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 RAP1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 CDK2AP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 BRPF1 25348397 N/A physical interaction ComPPI
XRCC1 GTF2IRD1 25348397 N/A physical interaction ComPPI
XRCC1 PPIH 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 XPOT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 SF3B6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 SLC39A10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 RPUSD4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 DPH7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 CREB1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
XRCC1 MAX 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
XRCC1 FOXD3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
XRCC1 FOXP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
XRCC1 HSP90AA2P 25348397 N/A physical interaction ComPPI
XRCC1 RBBP8 25348397 N/A physical interaction ComPPI
XRCC1 NFATC2 25348397 N/A physical interaction ComPPI
XRCC1 CDC14B 25348397 N/A physical interaction ComPPI
XRCC1 PCDHB11 25348397 N/A physical interaction ComPPI
XRCC1 XRCC6 25348397 N/A physical interaction ComPPI
XRCC1 CRBN 25348397 N/A physical interaction ComPPI
XRCC1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
XRCC1 CHEK2 18971944 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
XRCC1 CCNO 18971944 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XRCC1 MPG 18971944 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XRCC1 POLL 18971944 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XRCC1 H2AX 19851285 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
XRCC1 TDP1 19851285 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
XRCC1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
XRCC1 KSR2 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
XRCC1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
XRCC1 AIFM1 24234451 25348397 29568061 association pull down ComPPI,IntAct
RPA1 XRCC1 25348397 N/A physical interaction ComPPI
CSNK2A2 XRCC1 14525934 15367657 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
H3C1 XRCC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ARL6IP5 XRCC1 25348397 N/A physical interaction ComPPI
L1TD1 XRCC1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
CHEK2 XRCC1 18971944 27898060 stimulant N/A OmniPath
E2F1 XRCC1 18348985 27898060 stimulant N/A OmniPath
XRCC1 POLB 11467963 15107487 15367657 15520167 16442856 16713569 26186194 26496610 27898060 8978692 stimulant N/A OmniPath
CSNK2A1 XRCC1 15066279 15367657 18452278 20471329 25477519 27898060 stimulant N/A OmniPath
PARP1 XRCC1 12897160 14500814 15044383 15555565 16713569 18971944 19643912 20302655 20303835 27898060 9584196 9592149 stimulant N/A OmniPath
PRKDC XRCC1 16397295 27898060 N/A N/A OmniPath
XRCC1 PNKP 11163244 15367657 15385968 17353931 19155274 21637298 26496610 27898060 stimulant N/A OmniPath
CSNK2A2 XRCC1 15066279 15367657 18452278 27898060 stimulant N/A OmniPath

Visualization










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