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GENE：NQO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NQO1
FullNmae NAD(P)H quinone dehydrogenase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2874
EnsembleID ENSG00000181019
Uniprot P15559

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NQO1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NQO1 ferroptosis 40086519 Using RNA immunoprecipitation analyses, we identified several ferroptosis-regulating proteins, including NAD(P)H dehydrogenase [quinone] 1 (NQO1) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2). retulator signature
NQO1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NQO1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NQO1 GO:0002931,GO:0003723,GO:0003955,GO:0004128,GO:0004784,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006116,GO:0006743,GO:0006805,GO:0006809,GO:0006979,GO:0007271,GO:0007584,GO:0008753,GO:0009636,GO:0009725,GO:0009743,GO:0014075,GO:0019430,GO:0030163,GO:0030425,GO:0032355,GO:0032496,GO:0033574,GO:0034599,GO:0042177,GO:0042360,GO:0042373,GO:0042802,GO:0043025,GO:0043066,GO:0043279,GO:0043525,GO:0045087,GO:0045202,GO:0045454,GO:0045471,GO:0050136,GO:0051602,GO:0070301,GO:0070995,GO:0071248,GO:1904772,GO:1904844,GO:1904880,GO:1905395

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NQO1 hsa:1728 path:hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human)
NQO1 hsa:1728 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NQO1 hsa:1728 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
NQO1 hsa:1728 path:hsa05200 Pathways in cancer - Homo sapiens (human)
NQO1 hsa:1728 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NQO1 hsa:1728 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
NQO1 hsa:1728 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NQO1 NFE2L2 20309604 23180781 physical association anti tag coimmunoprecipitation InnateDB
YY1 NQO1 20309604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NQO1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOS NQO1 18971253 8004128 9058597 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
GATA2 NQO1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
JUN NQO1 11035254 8004128 9058597 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MAFG NQO1 11013233 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
NFKB1 NQO1 9058597 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
RELA NQO1 9058597 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
MAFK NQO1 11013233 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NQO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 NQO1 20623181 trascriptional regulation,stimulation inferred by curator TFlink
JUNB NQO1 11035254 trascriptional regulation,stimulation inferred by curator TFlink
JUND NQO1 11035254 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L1 NQO1 11013233 11035254 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L2 NQO1 11013233 11035254 22459801 trascriptional regulation,stimulation inferred by curator TFlink
NRF1 NQO1 11035254 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 NQO1 20623181 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A NQO1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
TP53 NQO1 25361965 interaction type N/A PTMCode2
NQO1 TP53 25361965 interaction type N/A PTMCode2
NQO1 HSPA1A 25361965 interaction type N/A PTMCode2
HSPA1A NQO1 25361965 interaction type N/A PTMCode2
NQO1 NQO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 NQO1 25348397 N/A physical interaction ComPPI
UBE2D1 NQO1 25348397 N/A physical interaction ComPPI
NFE2L2 NQO1 25348397 N/A physical interaction ComPPI
PARP1 NQO1 25348397 N/A physical interaction ComPPI
HSPA1A NQO1 11821413 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA1B NQO1 25348397 N/A in vitro ComPPI
ING1 NQO1 18388957 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction,in vivo ComPPI,IntAct
NME1 NQO1 25348397 N/A physical interaction ComPPI
HSPA4 NQO1 25348397 N/A physical interaction ComPPI
LAMB1 NQO1 25348397 N/A physical interaction ComPPI
VCAM1 NQO1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 NQO1 25348397 N/A physical interaction ComPPI
TRIM25 NQO1 25348397 N/A physical interaction ComPPI
DNAJB1 NQO1 11821413 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STUB1 NQO1 21220432 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NDUFS7 NQO1 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAZAP1 NQO1 25348397 N/A physical interaction ComPPI
POLDIP3 NQO1 25348397 N/A physical interaction ComPPI
NQO1 TP53 12529318 14525934 14634213 25348397 26540344 27898060 N/A coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
NQO1 YTHDF1 25348397 N/A physical interaction ComPPI
NQO1 RPS19 25348397 N/A physical interaction ComPPI
NQO1 FN1 25348397 N/A physical interaction ComPPI
NQO1 FOS 25348397 N/A physical interaction ComPPI
NQO1 MOV10 25348397 N/A physical interaction ComPPI
NQO1 NXF1 25348397 N/A physical interaction ComPPI
NQO1 ADK 25348397 N/A physical interaction ComPPI
NQO1 FUBP3 25348397 N/A physical interaction ComPPI
NQO1 GOT1 25348397 N/A physical interaction ComPPI
NQO1 GALT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NQO1 NQO1 10543876 14525934 24234451 25143260 N/A experimental interaction detection,molecular sieving,nuclear magnetic resonance,x-ray crystallography HPRD,IntAct
BACH1 NQO1 15734732 27898060 inhibition N/A OmniPath
KDM2B NQO1 18838535 27898060 stimulant N/A OmniPath
NFE2L2 NQO1 18241676 18535259 27898060 stimulant N/A OmniPath

Visualization










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