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GENE：EPHX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EPHX1
FullNmae epoxide hydrolase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3401
EnsembleID ENSG00000143819
Uniprot P07099

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EPHX1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EPHX1 GO:0004301,GO:0004301,GO:0005515,GO:0005789,GO:0006805,GO:0009636,GO:0014070,GO:0019369,GO:0019369,GO:0019439,GO:0033961,GO:0033961,GO:0097176,GO:0097176

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EPHX1 hsa:2052 path:hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
EPHX1 hsa:2052 path:hsa04976 Bile secretion - Homo sapiens (human)
EPHX1 hsa:2052 path:hsa05204 Chemical carcinogenesis - DNA adducts - Homo sapiens (human)
EPHX1 hsa:2052 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
EPHX1 hsa:2052 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EPHX1 CEBPA 15150264 23180781 physical association electrophoretic mobility supershift assay InnateDB
NFYA EPHX1 15150264 23180781 physical association electrophoretic mobility supershift assay InnateDB
RNF2 EPHX1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 EPHX1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EPHX1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC EPHX1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 EPHX1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 EPHX1 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SP1 EPHX1 24315822 trascriptional regulation,stimulation inferred by curator TFlink
SP3 EPHX1 24315822 trascriptional regulation,stimulation inferred by curator TFlink
PARP1 EPHX1 25992604 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 EPHX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 EPHX1 21512034 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 EPHX1 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
NMUR2 EPHX1 25348397 N/A physical interaction ComPPI
TRAF1 EPHX1 25348397 N/A physical interaction ComPPI
RNF2 EPHX1 25348397 N/A physical interaction ComPPI
DNAJB11 EPHX1 25348397 N/A physical interaction ComPPI
CDKN2AIP EPHX1 25348397 N/A physical interaction ComPPI
DERL1 EPHX1 25348397 N/A physical interaction ComPPI
KCNS3 EPHX1 25348397 N/A physical interaction ComPPI
CKMT1A EPHX1 25348397 N/A physical interaction ComPPI
SPINT2 EPHX1 25348397 N/A physical interaction ComPPI
RAB34 EPHX1 25348397 N/A physical interaction ComPPI
PTGER3 EPHX1 25348397 N/A physical interaction ComPPI
TMED10 EPHX1 25348397 N/A physical interaction ComPPI
FAM189A2 EPHX1 25348397 N/A physical interaction ComPPI
SRPRB EPHX1 25348397 N/A physical interaction ComPPI
EVA1C EPHX1 25348397 N/A physical interaction ComPPI
NXF1 EPHX1 25348397 N/A physical interaction ComPPI
TSPAN17 EPHX1 25348397 N/A physical interaction ComPPI
HADHA EPHX1 25348397 N/A physical interaction ComPPI
TMX1 EPHX1 25348397 N/A physical interaction ComPPI
RAB34 EPHX1 25348397 N/A physical interaction ComPPI
TMEM30A EPHX1 25348397 N/A physical interaction ComPPI
EPHX1 HPDL 25348397 N/A physical interaction ComPPI
EPHX1 ATP4A 25348397 N/A physical interaction ComPPI
EPHX1 TREML2 25348397 N/A physical interaction ComPPI
EPHX1 IQCF1 25348397 N/A physical interaction ComPPI
EPHX1 CHRNA9 25348397 N/A physical interaction ComPPI
EPHX1 MFSD8 25348397 N/A physical interaction ComPPI
EPHX1 PCDHGB4 25348397 N/A physical interaction ComPPI
EPHX1 PCDHGA5 25348397 N/A physical interaction ComPPI

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