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GENE：FOSL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOSL1
FullNmae FOS like 1, AP-1 transcription factor subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13718
EnsembleID ENSG00000175592
Uniprot P15407

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOSL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FOSL1 GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001701,GO:0002224,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0006357,GO:0006357,GO:0006935,GO:0006954,GO:0006968,GO:0007296,GO:0007565,GO:0007612,GO:0008284,GO:0008285,GO:0009410,GO:0009611,GO:0009612,GO:0009615,GO:0009629,GO:0010467,GO:0019221,GO:0031668,GO:0032570,GO:0042542,GO:0042734,GO:0043065,GO:0045787,GO:0045944,GO:0051412,GO:0051591,GO:0060674,GO:0090575,GO:0140467,GO:1902895,GO:1990837,GO:1990841,GO:2000144

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOSL1 hsa:8061 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
FOSL1 hsa:8061 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
FOSL1 hsa:8061 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
FOSL1 hsa:8061 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOSL1 MMP1 18802113 23180781 physical association electrophoretic mobility supershift assay InnateDB
FOSL1 IL11 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
ELF1 FOSL1 23180781 7648395 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR FOSL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 FOSL1 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FOSL1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC FOSL1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 FOSL1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FOSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 FOSL1 15806162 trascriptional regulation,stimulation inferred by curator TFlink
FOSL2 FOSL1 13679379 trascriptional regulation,stimulation inferred by curator TFlink
JUN FOSL1 13679379 15806162 trascriptional regulation,stimulation inferred by curator TFlink
JUND FOSL1 13679379 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 FOSL1 21072196 trascriptional regulation,stimulation inferred by curator TFlink
RBMX FOSL1 16707624 trascriptional regulation,stimulation inferred by curator TFlink
SRF FOSL1 15806162 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 FOSL1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 FOSL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 FOSL1 22198213 rna interference,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 FOSL1 22198213 23001043 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000CBE63 FOSL1 23527086 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B FOSL1 23001043 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000BD6DC FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 FOSL1 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D2F5 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000568FF8 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DABC0 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000002103A FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F74F1 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F31F4 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000053B1E8 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237E04 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000058DCD8 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000EF0B FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001F5B39 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003758F0 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F0130 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AEA5 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DA458 FOSL1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD FOSL1 22135298 phosphorylation N/A PhosphoSite
PRKCQ FOSL1 22135298 phosphorylation N/A PhosphoSite
FOSL1 JUN 25361965 interaction type N/A PTMCode2
JUN FOSL1 25361965 interaction type N/A PTMCode2
JUNB FOSL1 25361965 interaction type N/A PTMCode2
FOSL1 JUNB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 FOSL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GCC1 FOSL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LDOC1 FOSL1 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSMC3 FOSL1 21874050 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATF4 FOSL1 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
CEBPG FOSL1 25348397 N/A physical interaction ComPPI
KPNA1 FOSL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATXN1 FOSL1 23275563 24234451 25348397 physical association physical interaction,two hybrid prey pooling approach ComPPI,IntAct
JUNB FOSL1 12371906 14525934 16189514 24029232 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
JUN FOSL1 11708771 11912197 14525934 20511396 24029232 24234451 25348397 26258633 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAF FOSL1 25348397 N/A physical interaction ComPPI
CREBBP FOSL1 25348397 N/A physical interaction ComPPI
EP300 FOSL1 17882273 21937452 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATF3 FOSL1 25348397 N/A physical interaction ComPPI
MAFB FOSL1 25348397 N/A physical interaction ComPPI
CREB5 FOSL1 25348397 N/A physical interaction ComPPI
JUND FOSL1 24029232 24234451 25348397 26258633 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MYC FOSL1 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRAF3 FOSL1 25348397 N/A physical interaction ComPPI
CALCOCO1 FOSL1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TRIM24 FOSL1 25348397 N/A physical interaction ComPPI
XPA FOSL1 25348397 N/A affinity chromatography technology,physical interaction ComPPI
USF1 FOSL1 14525934 24234451 25348397 25416956 9160889 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CEBPE FOSL1 25348397 N/A physical interaction ComPPI
TAB2 FOSL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DNMT3L FOSL1 25348397 N/A physical interaction ComPPI
ATF2 FOSL1 25348397 N/A physical interaction ComPPI
CEBPA FOSL1 25348397 N/A physical interaction ComPPI
DDIT3 FOSL1 25348397 N/A physical interaction ComPPI
TICAM1 FOSL1 25348397 N/A physical interaction ComPPI
FOSL1 HDAC1 25348397 N/A physical interaction ComPPI
FOSL1 PARVG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FOSL1 WFDC1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FOSL1 NME7 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FOSL1 TEAD1 24234451 25348397 26258633 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL1 CCDC120 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BATF3 FOSL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKCQ FOSL1 21822309 22286759 27898060 N/A N/A OmniPath
DDIT3 FOSL1 10523647 27898060 stimulant N/A OmniPath
APEX1 FOSL1 18786561 27898060 stimulant N/A OmniPath
GSK3B FOSL1 20154735 27898060 inhibition N/A OmniPath

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