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GENE：PRLR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRLR
FullNmae prolactin receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9446
EnsembleID ENSG00000113494
Uniprot P16471

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRLR pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRLR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRLR GO:0004925,GO:0004925,GO:0005515,GO:0005576,GO:0005886,GO:0006694,GO:0007171,GO:0007259,GO:0007566,GO:0007595,GO:0008284,GO:0008289,GO:0008289,GO:0009617,GO:0009897,GO:0009986,GO:0017046,GO:0017046,GO:0019221,GO:0019901,GO:0019955,GO:0030155,GO:0030856,GO:0030890,GO:0031904,GO:0031954,GO:0038161,GO:0042976,GO:0043066,GO:0043235,GO:0046872,GO:0060644,GO:0060736,GO:0060749,GO:0097011,GO:0120162

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRLR hsa:5618 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
PRLR hsa:5618 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
PRLR hsa:5618 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PRLR hsa:5618 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PRLR hsa:5618 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRLR CISH 11713228 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRL PRLR 10585417 10966654 15082796 16546209 18988627 20053995 21889455 23180781 23331499 24243840 29145629 7984244 9626554 stimulation,physical association x-ray crystallography,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
GH2 PRLR 15082796 16546209 20053995 24243840 29145629 physical association inferred by curator Reactome
CSH1 PRLR 15082796 16546209 20053995 24243840 29145629 physical association inferred by curator Reactome
PRLR PRLR 16840534 22649370 24243840 29145629 physical association inferred by curator Reactome
GH1 PRLR 15082796 16546209 20053995 23331499 24243840 29145629 7984244 stimulation,physical association inferred by curator Reactome,SignaLink,SignaLink
PRLR CUL1 15082796 29145629 physical association inferred by curator Reactome
PRLR SKP1 15082796 29145629 physical association inferred by curator Reactome
PRLR BTRC 15082796 29145629 physical association inferred by curator Reactome
PRLR STAT5B 24243840 29145629 physical association inferred by curator Reactome
PRLR STAT5A 10582086 23331499 24243840 29145629 stimulation,physical association inferred by curator Reactome,SignaLink,SignaLink
PRLR JAK2 10772872 11713228 18988627 20962278 21071413 23331499 stimulation N/A SignaLink,SignaLink
SOCS3 PRLR 11713228 18988627 23331499 stimulation N/A SignaLink,SignaLink
CISH PRLR 11713228 18988627 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR PRLR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PRLR 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PRLR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C PRLR 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 PRLR 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000D6C3F PRLR 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000512C88 PRLR 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA PRLR 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 PRLR 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00002CBC6D PRLR 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 PRLR 22291592 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE PRLR 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 PRLR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB PRLR 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SOCS2 PRLR 25361965 interaction type N/A PTMCode2
PRLR SOCS2 25361965 interaction type N/A PTMCode2
PRLR PPIA 25361965 interaction type N/A PTMCode2
PPIA PRLR 25361965 interaction type N/A PTMCode2
CSH1 PRLR 25361965 interaction type N/A PTMCode2
PRLR CSH1 25361965 interaction type N/A PTMCode2
VAV2 PRLR 25361965 interaction type N/A PTMCode2
PRLR VAV2 25361965 interaction type N/A PTMCode2
PRL PRLR 25361965 interaction type N/A PTMCode2
PRLR PRL 25361965 interaction type N/A PTMCode2
JAK2 PRLR 25361965 interaction type N/A PTMCode2
PRLR JAK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 PRLR 11713228 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAG PRLR 12819209 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
INSIG2 PRLR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAV1 PRLR 11328862 14525934 25348397 27898060 7768923 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PRLR PTPN11 10991949 14522994 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PRLR VAV2 14525934 15618286 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PRLR TEC 11328862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRLR YWHAZ 12819209 14525934 24234451 25348397 physical association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
PRLR CISH 11713228 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRLR NEK3 14525934 15618286 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PRLR SOCS2 10455112 14525934 25348397 9202403 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRLR PRL 10966654 14525934 25348397 7984244 9626554 N/A circular dichroism,experimental interaction detection,nuclear magnetic resonance,physical interaction,in vitro,in vivo ComPPI,HPRD
PRLR CSH1 25348397 N/A in vitro ComPPI
PRLR CSH2 25348397 N/A in vitro ComPPI
PRLR ZAP70 10221598 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRLR PPIA 12668872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRLR GH1 14525934 24234451 25348397 7984244 9556914 N/A experimental interaction detection,x-ray crystallography,in vitro ComPPI,HPRD,IntAct
PRLR JAK2 10772872 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRLR GTF3A 25348397 N/A physical interaction ComPPI
PRLR FBXW11 25348397 N/A physical interaction ComPPI
PRLR CREBBP 25348397 N/A physical interaction ComPPI
PRLR STAT5B 25348397 N/A physical interaction ComPPI
PRLR BTRC 25348397 N/A physical interaction ComPPI
PRLR PRLR 10966654 14525934 N/A experimental interaction detection HPRD
H1-1 PRLR 24234451 30021884 physical association cross-linking study IntAct
SOCS3 PRLR 11713228 27898060 inhibition,stimulant N/A OmniPath
PRLR STAT5A 10582086 27898060 stimulant N/A OmniPath
ATR PRLR 12819209 15082796 27898060 7537382 N/A N/A OmniPath
PRLR JAK2 10772872 11713228 17312100 20962278 27898060 9202403 stimulant N/A OmniPath
GH1 PRLR 27898060 7984244 9556914 stimulant N/A OmniPath
CISH PRLR 11713228 27898060 inhibition,stimulant N/A OmniPath
PRL PRLR 10585417 10966654 11356126 21889455 22325776 2558309 27898060 7984244 9626554 stimulant N/A OmniPath

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