GENE：PTCH1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PTCH1 |
| FullNmae | patched 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9585 |
| EnsembleID | ENSG00000185920 |
| Uniprot | Q13635 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PTCH1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PTCH1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PTCH1 | GO:0000122,GO:0001658,GO:0001701,GO:0001709,GO:0001843,GO:0003007,GO:0005113,GO:0005119,GO:0005119,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0005901,GO:0007224,GO:0007286,GO:0007346,GO:0007420,GO:0008158,GO:0008201,GO:0008589,GO:0009410,GO:0009612,GO:0009887,GO:0009953,GO:0009957,GO:0010157,GO:0010839,GO:0010875,GO:0015485,GO:0016485,GO:0021522,GO:0021532,GO:0021904,GO:0021997,GO:0030326,GO:0030332,GO:0030496,GO:0030666,GO:0030850,GO:0032355,GO:0032526,GO:0032880,GO:0035108,GO:0035137,GO:0040015,GO:0042593,GO:0043231,GO:0043433,GO:0043616,GO:0044294,GO:0044295,GO:0044877,GO:0045177,GO:0045606,GO:0045668,GO:0045879,GO:0045879,GO:0045879,GO:0045893,GO:0048471,GO:0048568,GO:0048745,GO:0051782,GO:0060037,GO:0060170,GO:0060603,GO:0060644,GO:0061005,GO:0061053,GO:0071397,GO:0071397,GO:0071679,GO:0072089,GO:0072203,GO:0072205,GO:0072659,GO:0097108,GO:0097108,GO:0097421,GO:2000647 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PTCH1 | hsa:5727 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| PTCH1 | hsa:5727 | path:hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| PTCH1 | hsa:5727 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| PTCH1 | hsa:5727 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| PTCH1 | hsa:5727 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| PTCH1 | hsa:5727 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NLRP1 | PTCH1 | 19465923 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTCH1 | CARD8 | 19465923 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTCH1 | FHL2 | 19465923 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTCH1 | CASP9 | 19465923 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTCH1 | GLI2 | 18319260 23180781 24058673 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTCH1 | PTCH1 | 12192414 14556242 26467481 | bind,down-regulates activity | N/A | Signor |
| PTCH1 | SMO | 14556242 23331499 | stimulation | N/A | SignaLink,SignaLink |
| SHH | PTCH1 | 14556242 23331499 | stimulation | N/A | SignaLink,SignaLink |
| IHH | PTCH1 | 19399989 23331499 | stimulation | N/A | SignaLink,SignaLink |
| DHH | PTCH1 | 19399989 23331499 9811851 | stimulation | N/A | SignaLink |
| IHHB | PTCH1 | 19422819 19422819 21559328 | inhibition | N/A | SignaFish |
| SHHA | PTCH1 | 19422819 | inhibition | N/A | SignaFish |
| PTCH1 | Q90X26 | 19422819 21228001 21559328 | inhibition | N/A | SignaFish |
| DHH | PTCH1 | 19422819 21118524 21559328 | inhibition | N/A | SignaFish |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PTCH1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PTCH1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | PTCH1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PTCH1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PTCH1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PTCH1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PTCH1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001AFC71 | PTCH1 | 22357618 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001AFC71 | PTCH1 | 22357618 24961235 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000F0F49 | PTCH1 | 24967963 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000040828B | PTCH1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | PTCH1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | PTCH1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | PTCH1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | PTCH1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | PTCH1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003758F0 | PTCH1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000060AABB | PTCH1 | 25416803 28365245 | mrna cleavage,inhibition | nucleotide sequence identification,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| B4GALT7 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CASP9 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA7 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SMURF2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| FHL2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGAV | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| WWP1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| PAM | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| WWP2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CAV1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA5 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| GCNT1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CHPF | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| GRK2 | PTCH1 | 19502428 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MGAT1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| NEDD4L | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ADAM17 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| YAP1 | PTCH1 | 24234451 25283809 25348397 | N/A | isothermal titration calorimetry,physical interaction | ComPPI,IntAct |
| PLXNA1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR3 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITCH | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CCNB1 | PTCH1 | 14525934 19502428 24234451 25348397 9926943 | association,physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct |
| ITGA4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ATF6B | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| NEDD4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SHH | PTCH1 | 14525934 19561609 24234451 25348397 9811851 | N/A | experimental interaction detection,nuclear magnetic resonance | ComPPI,HPRD,IntAct |
| SMURF1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SLIT2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-A | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SMO | PTCH1 | 11278759 14525934 24234451 25348397 9811851 | association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,confocal microscopy | ComPPI,HPRD,IntAct |
| SEMA4F | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| NPTX1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CNTNAP3 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ASPH | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| DDX19B | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| PLXNB2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM132A | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| SEMA6A | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| POMT2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ABCA2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA8 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| COL18A1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ST8SIA4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| B4GALT1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| TTC17 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| RNF130 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| HHIP | PTCH1 | 19561609 24234451 25348397 | physical association | nuclear magnetic resonance | ComPPI,IntAct |
| B4GALT3 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ST3GAL4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| TPST2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| EXT1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ENPP1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| TOR1AIP1 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| GALNT7 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CHST12 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| CNNM4 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-C | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CACNA2D2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | BPNT2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | TMEM160 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | NDST2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CNNM1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CHST14 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | SPPL2B | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | MUCL1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | COCH | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | TMEM131 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | MOXD1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | UGT8 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | HS6ST2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | SULF2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | MAN2A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | ARSK | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | NETO2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CCPG1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | ST3GAL6 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CHSY1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CACNA2D1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | UGT3A2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | MGAT5 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | PXYLP1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | DHFR2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | TXNDC15 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | B3GLCT | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | FUT11 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | ST6GALNAC3 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | ENDOG | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CEMIP2 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | LRFN3 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | 25348397 | N/A | physical interaction | ComPPI | |
| PTCH1 | MYORG | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | GALNT18 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | CHST3 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | BTN2A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | ABHD14A | 25348397 | N/A | physical interaction | ComPPI |
| POMGNT2 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| PTCH1 | IHH | 14525934 9811851 | N/A | experimental interaction detection | HPRD |
| DHH | PTCH1 | 14525934 9811851 | N/A | experimental interaction detection | HPRD |
| HIPK2 | PTCH1 | 12874272 14525934 | N/A | experimental interaction detection | HPRD |
| CDK1 | PTCH1 | 11331587 14525934 | N/A | experimental interaction detection | HPRD |
| PTCH1 | NLRP1 | 19465923 27898060 | N/A | N/A | OmniPath |
| GLI2 | PTCH1 | 16571352 27898060 | stimulant | N/A | OmniPath |
| CASP3 | PTCH1 | 12907805 23074268 27898060 | inhibition | N/A | OmniPath |
| PTCH1 | SMO | 11278759 12192414 14556242 16867986 20076617 20207148 27898060 9811851 | inhibition,stimulant | N/A | OmniPath |
| SHH | PTCH1 | 14556242 15618519 19561609 20083481 27898060 9811851 | inhibition,stimulant | N/A | OmniPath |
| GLI1 | PTCH1 | 17419683 27898060 | inhibition,stimulant | N/A | OmniPath |
| PTCH1 | CCNB1 | 11331587 27898060 9926943 | stimulant | N/A | OmniPath |
| GLI3 | PTCH1 | 19860666 27898060 | stimulant | N/A | OmniPath |
| IHH | PTCH1 | 19399989 27898060 9811851 | inhibition,stimulant | N/A | OmniPath |
| DHH | PTCH1 | 19399989 27898060 8906787 9811851 | inhibition,stimulant | N/A | OmniPath |