GENE：DUSP6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DUSP6 |
| FullNmae | dual specificity phosphatase 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3072 |
| EnsembleID | ENSG00000139318 |
| Uniprot | Q16828 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DUSP6 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DUSP6 | GO:0000165,GO:0001933,GO:0004725,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0008138,GO:0008330,GO:0009410,GO:0014070,GO:0017017,GO:0017017,GO:0017018,GO:0030154,GO:0033550,GO:0035335,GO:0043065,GO:0043065,GO:0043409,GO:0051409,GO:0060420,GO:0070371,GO:0070373,GO:0070373,GO:0070848 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DUSP6 | hsa:1848 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| DUSP6 | hsa:1848 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| DUSP6 | hsa:1848 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F1 | DUSP6 | 23180781 24912499 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SRPK1 | DUSP6 | 23180781 23602568 | phosphorylation reaction | protein kinase assay | InnateDB |
| DUSP6 | MAPK1 | 23331499 9922370 | stimulation | N/A | SignaLink,SignaLink |
| DUSP6 | MAPK3 | 12840032 18988627 23331499 9535927 9922370 | stimulation | N/A | SignaLink,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | DUSP6 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | DUSP6 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DUSP6 | 18971253 20019798 20097731 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | DUSP6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | DUSP6 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | DUSP6 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | DUSP6 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DUSP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | DUSP6 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000ED600 | DUSP6 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000046CDA6 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F4657 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C28B2 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016E46F | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C04A2 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F8148 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | DUSP6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK3 | DUSP6 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | DUSP6 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| DUSP6 | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK14 | DUSP6 | 25361965 | interaction type | N/A | PTMCode2 |
| DUSP6 | MAPK14 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIN1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| ARPC3 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM11 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| ROR2 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| NME3 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| GTF2B | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| TIMMDC1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| MDFI | DUSP6 | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| NDUFAF4 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| ZNF212 | DUSP6 | 18255255 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MAPK1 | DUSP6 | 12840032 14525934 15632084 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| ERBB4 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK3 | DUSP6 | 12840032 14525934 24234451 25348397 9535927 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| MAPK14 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| UBE2G2 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| CHP1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| TAGLN | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| RAB5B | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| SRPK1 | DUSP6 | 23602568 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| SRPRA | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| TIMM17B | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| CAND1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| PTRH2 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| AP3S1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| VPS4A | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| LMTK2 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | TEX11 | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| DUSP6 | FAM217B | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | GET1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | TMEM126A | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | NKIRAS2 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | MGRN1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | PARK7 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | MBLAC2 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | FDFT1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | APOOL | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | TIMM21 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | ARF5 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | CYBC1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | GLT8D1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | AURKB | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | RDH14 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | HDDC2 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | PTPMT1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | TMEM97 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | MAIP1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | UBXN1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | TMCO1 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | DUSP8 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | SRM | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | SLC25A19 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | CNOT10 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | RAB13 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | MGARP | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | DUSP9 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | AATK | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | LTK | 25348397 | N/A | physical interaction | ComPPI |
| COX4I1 | DUSP6 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP6 | FOXO1 | 22521266 27898060 | stimulant | N/A | OmniPath |
| ZBTB16 | DUSP6 | 19723763 27898060 | stimulant | N/A | OmniPath |
| DUSP6 | MAPK6 | 18632752 27898060 | inhibition | N/A | OmniPath |
| MAPK3 | DUSP6 | 12840032 15632084 25515236 27898060 9535927 | inhibition,stimulant | N/A | OmniPath |
| DUSP6 | MAPK3 | 12840032 15632084 25515236 27898060 9535927 9922370 | inhibition,stimulant | N/A | OmniPath |
| MAPK1 | DUSP6 | 10811804 12840032 15632084 16567630 17046812 22848439 25515236 27898060 9535927 | inhibition,stimulant | N/A | OmniPath |
| DUSP6 | MAPK1 | 10811804 12840032 15632084 16567630 17046812 25515236 27898060 8670865 9535927 9922370 | inhibition,stimulant | N/A | OmniPath |