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GENE：RHOA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RHOA
FullNmae ras homolog family member A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:667
EnsembleID ENSG00000067560
Uniprot P61586

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RHOA mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHOA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RHOA entotic_cd 38218945 We characterized the different stages and the molecular regulators of entosis induced after Rnd3 silencing. We demonstrated that this process depends on the RhoA/ROCK pathway, but not on E-cadherin. retulator signature
RHOA entotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
RHOA apoptosis 16496227 In erythroblastic cell lines, TF-1 and D2, upregulation of the RhoA signaling promotes phorbol ester-induced apoptosis through activating Rho-associated kinase (ROCK)/phosphorylation of myosin light chain (MLC), thus generating membrane contraction force. retulator signature

Go Annotation:

GeneSymbol Go id
RHOA GO:0000902,GO:0001764,GO:0001822,GO:0001998,GO:0002363,GO:0003100,GO:0003189,GO:0003924,GO:0003924,GO:0003924,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005525,GO:0005634,GO:0005768,GO:0005789,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0005925,GO:0005938,GO:0006357,GO:0007160,GO:0007266,GO:0007266,GO:0007266,GO:0007266,GO:0007519,GO:0009898,GO:0010812,GO:0010975,GO:0016477,GO:0016477,GO:0016477,GO:0016477,GO:0017022,GO:0019901,GO:0021762,GO:0021795,GO:0021861,GO:0030027,GO:0030036,GO:0030036,GO:0030054,GO:0030334,GO:0030496,GO:0030521,GO:0030667,GO:0031122,GO:0031982,GO:0032154,GO:0032467,GO:0032587,GO:0032956,GO:0033144,GO:0033688,GO:0034329,GO:0034446,GO:0035385,GO:0036089,GO:0038027,GO:0042476,GO:0043123,GO:0043149,GO:0043149,GO:0043197,GO:0043197,GO:0043296,GO:0043297,GO:0043366,GO:0043542,GO:0043931,GO:0044319,GO:0045198,GO:0045666,GO:0045792,GO:0046638,GO:0050919,GO:0051496,GO:0051496,GO:0051893,GO:0060071,GO:0060193,GO:0060193,GO:0061383,GO:0070062,GO:0070507,GO:0071222,GO:0071345,GO:0071803,GO:0071902,GO:0071944,GO:0090051,GO:0090307,GO:0090324,GO:0097049,GO:0097498,GO:0098794,GO:0098794,GO:0098978,GO:0098978,GO:0099159,GO:0099159,GO:0101003,GO:1901224,GO:1901224,GO:1902766,GO:1903427,GO:1903673,GO:1904695,GO:1904996,GO:1905274,GO:1905274,GO:1990869,GO:2000177,GO:2000406,GO:2000672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RHOA hsa:387 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04144 Endocytosis - Homo sapiens (human)
RHOA hsa:387 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
RHOA hsa:387 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04360 Axon guidance - Homo sapiens (human)
RHOA hsa:387 path:hsa04510 Focal adhesion - Homo sapiens (human)
RHOA hsa:387 path:hsa04520 Adherens junction - Homo sapiens (human)
RHOA hsa:387 path:hsa04530 Tight junction - Homo sapiens (human)
RHOA hsa:387 path:hsa04611 Platelet activation - Homo sapiens (human)
RHOA hsa:387 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
RHOA hsa:387 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
RHOA hsa:387 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
RHOA hsa:387 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
RHOA hsa:387 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
RHOA hsa:387 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
RHOA hsa:387 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
RHOA hsa:387 path:hsa05131 Shigellosis - Homo sapiens (human)
RHOA hsa:387 path:hsa05132 Salmonella infection - Homo sapiens (human)
RHOA hsa:387 path:hsa05133 Pertussis - Homo sapiens (human)
RHOA hsa:387 path:hsa05135 Yersinia infection - Homo sapiens (human)
RHOA hsa:387 path:hsa05152 Tuberculosis - Homo sapiens (human)
RHOA hsa:387 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
RHOA hsa:387 path:hsa05200 Pathways in cancer - Homo sapiens (human)
RHOA hsa:387 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
RHOA hsa:387 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
RHOA hsa:387 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
RHOA hsa:387 path:hsa05210 Colorectal cancer - Homo sapiens (human)
RHOA hsa:387 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
RHOA hsa:387 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APC2 RHOA 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
CTHRC1 RHOA 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
RACK1 RHOA 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
RHOA DAAM1 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
ROR2 RHOA 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
RSPO3 RHOA 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26192618 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605 interaction type N/A ACSN
EGF RHOA 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 26192618 8101258 interaction type N/A ACSN
ARHGAP35 RHOA 17517963 18829532 22411312 26192618 8360177 9819392 interaction type N/A ACSN
CXCL12 RHOA 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834 26192618 interaction type N/A ACSN
CXCR4 RHOA 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834 26192618 interaction type N/A ACSN
PTP4A3 RHOA 16540666 17192274 17409395 18268019 20681446 22677902 22825514 23691193 24030100 24376839 25687758 26192618 27036022 27452906 interaction type N/A ACSN
PARD6A RHOA 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611 26192618 interaction type N/A ACSN
SMURF1 RHOA 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611 26192618 interaction type N/A ACSN
RHOA RHO 26192618 interaction type N/A ACSN
VAV1 RHOA 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14757747 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 23109003 25355530 25539813 26192618 26552706 8189062 8226994 9438848 9695188 interaction type,chemical activation reaction N/A ACSN,SignaLink
RHOA ROCK1 11698448 11729192 11739775 11992112 12194823 12361600 12727213 12740575 14657501 14744429 15761148 17517963 17673200 18037882 18423981 20535745 21178402 22949611 23109003 24857661 24919149 26192618 26885855 27048821 27066895 7479854 9362522 9660866 9822605 interaction type,chemical activation reaction N/A ACSN,SignaLink
RHOA PTEN 10953004 11698448 11729192 11739775 11992112 12194823 12361600 12740575 12778124 14657501 14744429 15761148 15764699 15793569 15803130 17517963 18037882 18423981 20008297 20351293 20535745 21178402 21642958 21840487 22244698 22949611 23109003 24857661 24919149 26192618 26885855 27048821 27066895 7479854 9362522 9660866 9822605 interaction type,chemical activation reaction N/A ACSN,SignaLink
RAP1GDS1 RHOA 11948427 23180781 physical association two hybrid InnateDB
RHOA RTKN 16449524 23180781 physical association gst pull down InnateDB
AKAP13 RHOA 19696020 23180781 physical association anti tag coimmunoprecipitation InnateDB
RHOA ARHGDIA 11368848 23180781 25416956 physical association two hybrid InnateDB
RHOA TRIP6 23180781 25416956 physical association two hybrid InnateDB
RHOA RIPOR2 23180781 25416956 physical association two hybrid InnateDB
RHOA IKZF3 23180781 25416956 physical association two hybrid InnateDB
RHOA RHOA 22430126 23151663 26467481 bind,up-regulates activity N/A Signor
RHOA PLCG1 12071848 23331499 stimulation N/A SignaLink
ARHGAP32 RHOA 12454018 23331499 stimulation N/A SignaLink
RHOA ROCK2 12727213 17673200 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CAV1 RHOA 20005715 interaction type N/A PSP
CNKSR1 RHOA 20005715 interaction type N/A PSP,SignaLink
DVL2 RHOA 20005715 interaction type N/A PSP,SignaLink
FADD RHOA 20005715 interaction type N/A PSP
RHPN2 RHOA 20005715 interaction type N/A PSP
CAV1 RHOA 18988627 20005715 20460433 21071413 9647788 N/A N/A SignaLink
FADD RHOA 15659383 20005715 20005715 21071413 N/A N/A SignaLink
RHPN2 RHOA 12221077 12773565 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR RHOA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RHOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RHOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RHOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RHOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RHOA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PTTG1 RHOA 22081074 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 RHOA 19857574 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC RHOA 19617899 19935707 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000338542 RHOA 18794355 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00002367FA RHOA 21186079 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 RHOA 23272142 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 RHOA 19524507 22854067 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000ED600 RHOA 20584986 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr miRSponge
URS0000001EB3 RHOA 19524507 22736314 22854067 25416803 27904131 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00003380CC RHOA 19617899 19935707 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000338542 RHOA 18794355 25416803 28146427 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002367FA RHOA 21186079 25416803 27250838 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 RHOA 23272142 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000ED600 RHOA 20584986 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS000050CCE0 RHOA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 RHOA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000032BD73 RHOA 22179829 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000045DBD RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000753AD RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 RHOA 23525486 23592263 25416803 26148871 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000007FBA RHOA 24980435 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F507C RHOA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF RHOA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 RHOA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000547F6A RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CC20C RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003ACE11 RHOA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 RHOA 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001597DC RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004CD810 RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000024A59E RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003FA24D RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000058DCD8 RHOA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B RHOA 19536157 25416803 26148871 26701625 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000015188E RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 RHOA 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD RHOA 25416803 25909223 26903801 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 RHOA 25416803 27175941 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001496AE RHOA 25416803 27524906 mrna cleavage,inhibition western blot,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001F8FF2 RHOA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 RHOA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 RHOA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 RHOA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C RHOA 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA RHOA 22135298 phosphorylation N/A PhosphoSite
MAPK3 RHOA 22135298 phosphorylation N/A PhosphoSite
PRKG1 RHOA 22135298 phosphorylation N/A PhosphoSite
RHPN2 RHOA 25361965 interaction type N/A PTMCode2
RHOA RHPN2 25361965 interaction type N/A PTMCode2
ARHGDIA RHOA 25361965 interaction type N/A PTMCode2
RHOA ARHGDIA 25361965 interaction type N/A PTMCode2
TNFAIP1 RHOA 25361965 interaction type N/A PTMCode2
RHOA TNFAIP1 25361965 interaction type N/A PTMCode2
RHOA FNTA 25361965 interaction type N/A PTMCode2
FNTA RHOA 25361965 interaction type N/A PTMCode2
RHOA ARHGEF1 25361965 interaction type N/A PTMCode2
ARHGEF1 RHOA 25361965 interaction type N/A PTMCode2
RHOA ARHGEF3 25361965 interaction type N/A PTMCode2
ARHGEF3 RHOA 25361965 interaction type N/A PTMCode2
RHOA NEK2 25361965 interaction type N/A PTMCode2
NEK2 RHOA 25361965 interaction type N/A PTMCode2
RHOA PGGT1B 25361965 interaction type N/A PTMCode2
PGGT1B RHOA 25361965 interaction type N/A PTMCode2
RTKN RHOA 25361965 interaction type N/A PTMCode2
RHOA RTKN 25361965 interaction type N/A PTMCode2
RHOA ARHGAP1 25361965 interaction type N/A PTMCode2
ARHGAP1 RHOA 25361965 interaction type N/A PTMCode2
RHOA DIAPH1 25361965 interaction type N/A PTMCode2
DIAPH1 RHOA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ARHGDIG RHOA 14525934 25348397 9113980 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DEF6 RHOA 14525934 15023524 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDE6D RHOA 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
KRAS RHOA 25348397 N/A physical interaction ComPPI
S100A4 RHOA 25348397 N/A physical interaction ComPPI
NUTF2 RHOA 25348397 N/A physical interaction ComPPI
CDKN1B RHOA 19470470 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CLNS1A RHOA 25348397 N/A physical interaction ComPPI
NUBP2 RHOA 25348397 N/A physical interaction ComPPI
RHOC RHOA 25348397 N/A physical interaction ComPPI
RHOA KCNA2 14525934 25348397 27898060 9635436 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
RHOA PRKCA 11284700 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA TGM2 11350930 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA FLNA 10051605 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA OPHN1 11998687 14525934 25348397 9582072 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA MCF2 10854437 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA KTN1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
RHOA VAV2 11909943 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA PKN1 10619026 14525934 24234451 25348397 8571127 9446575 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOA DGKQ 10066731 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RHOA PRKACA 12654918 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RHOA ROCK1 14525934 14660612 21281639 24234451 25348397 8798490 association,physical association two hybrid,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RHOA TRIO 10948190 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA ARHGDIA 10489445 14525934 17353931 20711218 24234451 25348397 25416956 physical association anti bait coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
RHOA PPP1R12A 14525934 15545284 24234451 25348397 9354661 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOA RTKN 12879077 14506264 14525934 18256687 19944695 22621765 22705156 24234451 25150978 25348397 8662891 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RHOA CNTNAP1 14525934 25348397 9407060 N/A experimental interaction detection,in vitro ComPPI,HPRD
RHOA PKN2 14525934 25348397 8910519 9121475 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHOA ARHGAP1 11927263 14525934 16189514 24234451 25348397 9548756 physical association experimental interaction detection,x-ray crystallography,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro ComPPI,HPRD,IntAct
RHOA ARHGDIB 14525934 25348397 9799233 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOA AKAP13 11696353 12423633 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOA RABAC1 11335720 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
RHOA ARHGEF4 10947987 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA VAV3 10523675 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA ARHGEF12 11373293 14525934 15364580 20300064 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOA CIT 14525934 25348397 8543060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RHOA ARHGEF11 10526156 14525934 15530360 20300064 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,gdp/gtp exchange assay ComPPI,HPRD,IntAct
RHOA ICMT 14525934 25348397 9614111 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA SRGAP1 11672528 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOA DAAM1 11779461 14525934 18218625 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RHOA RHPN2 12221077 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHOA SH3BP1 14525934 25348397 9548756 N/A experimental interaction detection,in vitro ComPPI,HPRD
RHOA ARHGEF2 14525934 24234451 25348397 9857026 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
RHOA GMIP 12093360 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RHOA RAP1GDS1 11948427 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RHOA TRPC1 12766172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHOA ARHGEF18 11085924 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA ARHGEF3 12221096 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOA ARHGEF25 14525934 15069594 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA MCF2L 25348397 N/A physical interaction,in vitro ComPPI
RHOA DOCK7 12432077 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RHOA RHPN1 12221077 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHOA SPRED2 14525934 15184877 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
RHOA PLEKHG2 11839748 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA ARHGAP21 14525934 15793564 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RHOA ARHGAP8 12944407 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RHOA CAV1 14525934 25348397 27898060 9647788 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RHOA VAV1 14525934 16397238 18511940 24234451 25348397 N/A experimental interaction detection,fluorescence technology,in vivo ComPPI,HPRD,IntAct
RHOA PRKCZ 14525934 15210811 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA DVL2 12533515 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA SMURF1 14525934 15710384 16472676 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOA DIAPH1 14525934 15864301 16109481 18218625 24234451 25348397 association experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro ComPPI,HPRD,IntAct
RHOA MPRIP 14506264 14525934 15545284 24234451 25348397 27898060 9199174 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
RHOA ARHGAP5 14525934 25348397 9407060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA HSPA1A 12490434 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
RHOA HSPA1B 25348397 N/A physical interaction,in vivo ComPPI
RHOA ITPR1 12766172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHOA BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RHOA TNFRSF10B 25348397 N/A physical interaction ComPPI
RHOA EZR 25348397 N/A physical interaction ComPPI
RHOA FADD 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RHOA FASLG 25348397 N/A physical interaction ComPPI
RHOA MAPK8 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RHOA MSN 25348397 N/A physical interaction ComPPI
RHOA CASP10 25348397 N/A physical interaction ComPPI
RHOA CASP8 25348397 N/A physical interaction ComPPI
RHOA FAS 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RHOA TNFRSF1A 25348397 N/A physical interaction ComPPI
RHOA ARHGAP32 25348397 N/A physical interaction ComPPI
RHOA RHPN2P1 25348397 N/A physical interaction ComPPI
RHOA ARHGEF1 25348397 N/A physical interaction ComPPI
RHOA PLD1 11311142 12593858 14525934 25348397 9565577 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RHOA NET1 25348397 N/A physical interaction ComPPI
RHOA PLCG1 12071848 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RHOA ARHGAP26 25348397 N/A physical interaction ComPPI
RHOA ARHGAP10 25348397 N/A physical interaction ComPPI
RHOA ARHGAP35 25348397 N/A physical interaction ComPPI
RHOA RIPK4 25348397 N/A physical interaction ComPPI
RHOA ROCK2 25348397 N/A physical interaction ComPPI
RHOA BCR 25348397 N/A physical interaction ComPPI
RHOA PLXNB1 25348397 N/A physical interaction ComPPI
RHOA SMURF2 17719543 20026602 21402695 24234451 25348397 27898060 enzymatic reaction physical interaction,enzymatic study ComPPI,IntAct,OmniPath
RHOA OTUB1 20553488 24234451 25348397 physical association affinity chromatography technology,physical interaction ComPPI,IntAct
RHOA CUL3 25348397 N/A physical interaction ComPPI
RHOA HTR1A 25348397 N/A physical interaction ComPPI
RHOA MAP3K1 14581471 21129722 24135036 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RHOA MDM2 25348397 N/A physical interaction ComPPI
RHOA PSMD10 25348397 N/A physical interaction ComPPI
RHOA MARK2 25348397 N/A physical interaction ComPPI
RHOA LRRK2 21454543 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA RPS27A 25348397 N/A physical interaction ComPPI
RHOA MPV17 25348397 N/A physical interaction ComPPI
RHOA PON2 25348397 N/A physical interaction ComPPI
RHOA PRDX6 25348397 N/A physical interaction ComPPI
RHOA SLC25A5 25348397 N/A physical interaction ComPPI
RHOA PLIN3 25348397 N/A physical interaction ComPPI
RHOA CPT1A 25348397 N/A physical interaction ComPPI
RHOA RPL18 25348397 N/A physical interaction ComPPI
RHOA DDX1 25348397 N/A physical interaction ComPPI
RHOA BAIAP2 25348397 N/A physical interaction ComPPI
RHOA DIAPH3 25348397 N/A physical interaction ComPPI
RHOA RACK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RHOA RPN2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RHOA RIPOR2 21988832 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RHOA SMAD2 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
RHOA TBXA2R 25348397 N/A physical interaction ComPPI
RHOA BIRC2 25348397 N/A physical interaction ComPPI
RHOA IKBKG 25348397 N/A physical interaction ComPPI
RHOA KCTD13 25348397 N/A physical interaction ComPPI
RHOA TNFAIP1 25348397 N/A physical interaction ComPPI
RHOA TRIP6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RHOA IKZF3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RHOA UBC 15710384 24234451 25348397 ubiquitination reaction anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA DCUN1D1 25348397 N/A physical interaction ComPPI
RHOA KLHL20 25348397 N/A physical interaction ComPPI
RHOA MBD5 25348397 N/A physical interaction ComPPI
RHOA SERPINB5 25348397 N/A physical interaction ComPPI
RHOA TM4SF20 25348397 N/A physical interaction ComPPI
RHOA DIRAS3 25348397 N/A physical interaction ComPPI
RHOA LDB3 25348397 N/A physical interaction ComPPI
RHOA TSC22D4 25348397 N/A physical interaction ComPPI
RHOA RASL10A 25348397 N/A physical interaction ComPPI
RHOA NAXE 25348397 N/A physical interaction ComPPI
RHOA GORASP2 25348397 N/A physical interaction ComPPI
RHOA PAFAH1B2 25348397 N/A physical interaction ComPPI
RHOA PRRC1 25348397 N/A physical interaction ComPPI
RHOA RPE 25348397 N/A physical interaction ComPPI
RHOA SHMT2 25348397 N/A physical interaction ComPPI
RHOA SLC25A12 25348397 N/A physical interaction ComPPI
RHOA CNKSR1 15670823 24234451 25348397 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,physical interaction ComPPI,IntAct
RHOA MED20 25348397 N/A physical interaction ComPPI
RHOA RPGR 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RHOA LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA ATP6AP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA NVL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA UBE2V2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA FUBP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA BAZ1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA STK39 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOA SYNPO2 25348397 N/A physical interaction ComPPI
RHOA RASSF1 25348397 N/A physical interaction ComPPI
RHOA ANLN 25348397 N/A physical interaction ComPPI
RHOA U2AF2 25348397 N/A physical interaction ComPPI
RHOA SH3GLB2 25348397 N/A physical interaction ComPPI
RHOA AGAP2 25348397 N/A physical interaction ComPPI
RHOA AGAP1 25348397 N/A physical interaction ComPPI
RHOA PKN3 25348397 N/A physical interaction ComPPI
RHOA DNAL1 25348397 N/A physical interaction ComPPI
RHOA RABL3 25348397 N/A physical interaction ComPPI
RHOA AK9 25348397 N/A physical interaction ComPPI
RHOA IRGC 25348397 N/A physical interaction ComPPI
RHOA RAP2C 25348397 N/A physical interaction ComPPI
RHOA HDAC7 25348397 N/A physical interaction ComPPI
RHOA GLB1 25348397 N/A physical interaction ComPPI
RHOA VASH1 25348397 N/A physical interaction ComPPI
RHOA CTSA 25348397 N/A physical interaction ComPPI
RHOA FGB 25348397 N/A physical interaction ComPPI
RHOA LUM 25348397 N/A physical interaction ComPPI
RHOA PTEN 25348397 N/A physical interaction ComPPI
RHOA COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA NOTCH1 25348397 N/A physical interaction ComPPI
RHOA ARHGEF5 12006984 24234451 25348397 physical association enzymatic study ComPPI,IntAct
RHOA HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RHOA UBB 17719543 24234451 25348397 enzymatic reaction enzymatic study ComPPI,IntAct
RHOA NGEF 18256687 24234451 25348397 physical association pull down ComPPI,IntAct
RHOA ARHGEF19 18256687 24234451 25348397 physical association pull down ComPPI,IntAct
RHOA AGER 19944695 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RHOA NCL 21281639 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
RHOA ARHGAP45 24086303 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
RHOA RIPOR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RHOA TRIM65 24234451 25348397 27829229 physical association coimmunoprecipitation ComPPI,IntAct
NFKBIA RHOA 25348397 N/A physical interaction ComPPI
RHOA RHOA 14525934 15069594 24234451 9748241 physical association experimental interaction detection,chromatography technology HPRD,IntAct
RASGRF1 RHOA 10220378 14525934 N/A experimental interaction detection HPRD
PITPNM1 RHOA 14525934 15125835 N/A experimental interaction detection HPRD
RHOA TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
MKI67 RHOA 24234451 26949251 association anti tag coimmunoprecipitation IntAct
SMARCB1 RHOA 24234451 30108113 association proximity-dependent biotin identification IntAct
PRKG1 RHOA 11162591 12654918 15890975 16109481 19737918 20591975 21572420 27898060 N/A N/A OmniPath
SRC RHOA 12654918 27898060 inhibition N/A OmniPath
RHOA PLCG1 12071848 27898060 stimulant N/A OmniPath
PRKACA RHOA 12654918 27898060 inhibition,stimulant N/A OmniPath
GNAQ RHOA 17606614 27898060 stimulant N/A OmniPath
RHOA DIAPH1 12773565 15864301 16109481 18218625 22820501 27898060 stimulant N/A OmniPath
STAT6 RHOA 20006706 27898060 stimulant N/A OmniPath
RHOA PLD1 11102529 11311142 12593858 27898060 9565577 stimulant N/A OmniPath
RHOA ROCK1 12773565 14660612 15774750 17145710 21281639 22430126 23151663 25010901 27898060 8798490 8816443 9535835 stimulant N/A OmniPath
GNA13 RHOA 23450633 27898060 stimulant N/A OmniPath
RHOA CIT 12773565 17332740 27898060 8543060 stimulant N/A OmniPath
ECT2 RHOA 15774750 27898060 stimulant N/A OmniPath
RHOA ROCK2 11350930 27898060 stimulant N/A OmniPath
RHOA PKN2 18835241 27898060 8910519 9121475 9446575 stimulant N/A OmniPath
TGFBR1 RHOA 15761153 19726546 27898060 stimulant N/A OmniPath
RIPOR2 RHOA 21516116 21988832 25416956 27898060 N/A N/A OmniPath
FZD3 RHOA 20828404 27898060 stimulant N/A OmniPath
RHOA AKAP13 11696353 12423633 19696020 27898060 N/A N/A OmniPath
DAAM1 RHOA 11779461 18218625 19365405 25241761 27898060 stimulant N/A OmniPath
ARHGAP32 RHOA 12446789 12454018 12857875 27898060 stimulant N/A OmniPath
ARHGDIA RHOA 10489445 11149925 11368848 14749388 15659383 17353931 20628200 20711218 25416956 26344197 27898060 9490022 stimulant N/A OmniPath
RHOA PFN1 22820501 27898060 stimulant N/A OmniPath
RTKN RHOA 12015964 12593858 12879077 14506264 14749388 14966563 15075243 16449524 18256687 19696020 19805522 19944695 22621765 22705156 26825171 27898060 8662891 N/A N/A OmniPath
RHOA FHL2 11847121 27898060 stimulant N/A OmniPath
ARHGEF12 RHOA 11094164 11373293 15364580 20300064 23405219 27898060 stimulant N/A OmniPath
ARHGEF1 RHOA 10836144 27898060 stimulant N/A OmniPath
GNA12 RHOA 23450633 27898060 stimulant N/A OmniPath
RAP1GDS1 RHOA 11948427 20709748 21242305 27898060 stimulant N/A OmniPath

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