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GENE：VTN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VTN
FullNmae vitronectin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12724
EnsembleID ENSG00000109072
Uniprot P04004

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VTN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VTN GO:0005044,GO:0005178,GO:0005178,GO:0005201,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005576,GO:0005604,GO:0005615,GO:0005615,GO:0005615,GO:0005783,GO:0005796,GO:0006897,GO:0006955,GO:0007155,GO:0007160,GO:0007160,GO:0007160,GO:0008201,GO:0010811,GO:0010951,GO:0014911,GO:0016477,GO:0030155,GO:0030195,GO:0030198,GO:0030247,GO:0030949,GO:0032092,GO:0033627,GO:0033627,GO:0035987,GO:0042802,GO:0043231,GO:0048237,GO:0048260,GO:0048709,GO:0050731,GO:0050840,GO:0051258,GO:0051918,GO:0061302,GO:0062023,GO:0062023,GO:0062023,GO:0062023,GO:0062023,GO:0070062,GO:0071062,GO:0072562,GO:0090303,GO:0097421,GO:0098637,GO:1904090

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VTN hsa:7448 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
VTN hsa:7448 path:hsa04510 Focal adhesion - Homo sapiens (human)
VTN hsa:7448 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
VTN hsa:7448 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
VTN hsa:7448 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
VTN hsa:7448 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
VTN ITGB5 26192618 26519775 interaction type N/A ACSN
VTN SPARC 23180781 9164872 physical association solid phase assay InnateDB
GZMB VTN 15843372 23180781 protein cleavage protease assay InnateDB
VTN HNF4A 14988562 23180781 physical association anti tag coimmunoprecipitation InnateDB
VTN HNF1A 14988562 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAD VTN 16239428 23180781 physical association surface plasmon resonance InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 VTN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 VTN 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 VTN 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 VTN 22135298 phosphorylation N/A PhosphoSite
PRKACA VTN 22135298 phosphorylation N/A PhosphoSite
PRKCA VTN 22135298 phosphorylation N/A PhosphoSite
ITGB8 VTN 25361965 interaction type N/A PTMCode2
VTN ITGB8 25361965 interaction type N/A PTMCode2
SERPINE1 VTN 25361965 interaction type N/A PTMCode2
VTN SERPINE1 25361965 interaction type N/A PTMCode2
TGFB1 VTN 25361965 interaction type N/A PTMCode2
VTN TGFB1 25361965 interaction type N/A PTMCode2
VTN IGFBP5 25361965 interaction type N/A PTMCode2
IGFBP5 VTN 25361965 interaction type N/A PTMCode2
VTN ITGAV 25361965 interaction type N/A PTMCode2
ITGAV VTN 25361965 interaction type N/A PTMCode2
VTN ITGB3 25361965 interaction type N/A PTMCode2
ITGB3 VTN 25361965 interaction type N/A PTMCode2
VTN FGF2 25361965 interaction type N/A PTMCode2
FGF2 VTN 25361965 interaction type N/A PTMCode2
VTN ITGB6 25361965 interaction type N/A PTMCode2
ITGB6 VTN 25361965 interaction type N/A PTMCode2
VTN ITGA8 25361965 interaction type N/A PTMCode2
ITGA8 VTN 25361965 interaction type N/A PTMCode2
VTN PVR 25361965 interaction type N/A PTMCode2
PVR VTN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GEM VTN 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HOXB9 VTN 25348397 N/A physical interaction ComPPI
CDC5L VTN 25348397 N/A physical interaction ComPPI
SAP18 VTN 25348397 N/A physical interaction ComPPI
DHX15 VTN 25348397 N/A physical interaction ComPPI
SNRPA1 VTN 25348397 N/A physical interaction ComPPI
FASTKD3 VTN 25348397 N/A physical interaction ComPPI
HAT1 VTN 25348397 N/A physical interaction ComPPI
TGFB1 VTN 11796824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGB5 VTN 1694173 24234451 25348397 physical association physical interaction,solid phase assay ComPPI,IntAct
PRPF40A VTN 25348397 N/A physical interaction ComPPI
VTN SERPINE1 11796824 12808446 14525934 24234451 25348397 8830783 9065424 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
VTN PLAUR 14525934 25348397 8830783 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
VTN PVR 11437656 25348397 27898060 N/A physical interaction,in vitro ComPPI,OmniPath
VTN POMC 14525934 2475499 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
VTN PRKCA 14525934 25348397 9030777 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN PRKCB 14525934 25348397 9030777 N/A experimental interaction detection,in vitro ComPPI,HPRD
VTN PRKCG 14525934 25348397 9030777 N/A experimental interaction detection,in vitro ComPPI,HPRD
VTN ITGB3 14525934 16195248 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VTN TGFB2 25348397 N/A physical interaction,in vitro ComPPI
VTN VEGFA 11796824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN KNG1 10887113 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
VTN AMPH 12565847 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
VTN PRKACA 14525934 1706595 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN LACRT 11419941 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN ITGB8 11156415 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VTN CSNK2A1 14525934 25348397 9733784 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
VTN ITGA8 25348397 N/A in vitro ComPPI
VTN TNFRSF11B 14525934 15799029 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
VTN HGF 14525934 15717924 25348397 N/A experimental interaction detection,enzyme linked immunosorbent assay,in vitro ComPPI,HPRD
VTN ITGB6 14525934 25348397 8120056 N/A experimental interaction detection,in vitro ComPPI,HPRD
VTN EGF 11796824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN FGG 11744726 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
VTN FGF2 11796824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VTN IGFBP5 11751588 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
VTN IGF2 10342887 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
VTN SPARC 25348397 N/A solid phase assay ComPPI
VTN COPS5 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VTN APP 25348397 N/A physical interaction ComPPI
VTN SRSF1 25348397 N/A physical interaction ComPPI
VTN SRSF10 25348397 N/A physical interaction ComPPI
VTN SEPTIN7 25348397 N/A physical interaction ComPPI
VTN SRSF11 25348397 N/A physical interaction ComPPI
VTN BUD31 25348397 N/A physical interaction ComPPI
VTN SAFB 25348397 N/A physical interaction ComPPI
VTN LUC7L3 25348397 N/A physical interaction ComPPI
VTN S100A9 25348397 N/A physical interaction ComPPI
VTN HNRNPR 25348397 N/A physical interaction ComPPI
VTN SNU13 25348397 N/A physical interaction ComPPI
VTN PRPF19 25348397 N/A physical interaction ComPPI
VTN SMU1 25348397 N/A physical interaction ComPPI
VTN HNRNPM 25348397 N/A physical interaction ComPPI
VTN PHGDH 25348397 N/A physical interaction ComPPI
VTN SF3B6 25348397 N/A physical interaction ComPPI
VTN PPP1CA 25348397 N/A physical interaction ComPPI
VTN DDX5 25348397 N/A physical interaction ComPPI
VTN PRPF8 25348397 N/A physical interaction ComPPI
VTN ILF3 25348397 N/A physical interaction ComPPI
VTN WDR18 25348397 N/A physical interaction ComPPI
VTN NFIA 25348397 N/A physical interaction ComPPI
VTN SF3B1 25348397 N/A physical interaction ComPPI
VTN SF3B3 25348397 N/A physical interaction ComPPI
VTN HNRNPU 25348397 N/A physical interaction ComPPI
VTN RBM25 25348397 N/A physical interaction ComPPI
VTN SMARCB1 25348397 N/A physical interaction ComPPI
VTN USP39 25348397 N/A physical interaction ComPPI
VTN SF3A1 25348397 N/A physical interaction ComPPI
VTN DSP 25348397 N/A physical interaction ComPPI
VTN DHX9 25348397 N/A physical interaction ComPPI
VTN RBM39 25348397 N/A physical interaction ComPPI
VTN SFPQ 25348397 N/A physical interaction ComPPI
VTN DDB1 25348397 N/A physical interaction ComPPI
VTN DEK 25348397 N/A physical interaction ComPPI
VTN RPS11 25348397 N/A physical interaction ComPPI
VTN HP1BP3 25348397 N/A physical interaction ComPPI
VTN ADTRP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN CKS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN CD247 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN ADH5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN GLUD1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VTN CRADD 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN PRDX4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VTN CBX1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN RPL13A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VTN ETV7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN RHOXF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VTN GOPC 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VTN CUL7 25348397 N/A physical interaction ComPPI
VTN EED 25348397 N/A physical interaction ComPPI
VTN UACA 25348397 N/A physical interaction ComPPI
VTN TRIOBP 25348397 N/A physical interaction ComPPI
VTN GLI4 25348397 N/A physical interaction ComPPI
VTN RAI14 25348397 N/A physical interaction ComPPI
VTN OTUD4 25348397 N/A physical interaction ComPPI
VTN CFAP410 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
VTN ZNF483 25348397 N/A physical interaction ComPPI
VTN GPRIN1 25348397 N/A physical interaction ComPPI
VTN ZNF696 25348397 N/A physical interaction ComPPI
VTN MPRIP 25348397 N/A physical interaction ComPPI
VTN RNF14 25348397 N/A physical interaction ComPPI
VTN LPCAT3 25348397 N/A physical interaction ComPPI
VTN RPP40 25348397 N/A physical interaction ComPPI
VTN ZNF777 25348397 N/A physical interaction ComPPI
VTN PTCD2 25348397 N/A physical interaction ComPPI
VTN FBXO33 25348397 N/A physical interaction ComPPI
VTN POP4 25348397 N/A physical interaction ComPPI
VTN WDR33 25348397 N/A physical interaction ComPPI
VTN RTN2 25348397 N/A physical interaction ComPPI
VTN RRP1 25348397 N/A physical interaction ComPPI
VTN MRS2 25348397 N/A physical interaction ComPPI
VTN TTLL4 25348397 N/A physical interaction ComPPI
VTN ISOC1 25348397 N/A physical interaction ComPPI
VTN KTN1 25348397 N/A physical interaction ComPPI
VTN HACD2 25348397 N/A physical interaction ComPPI
VTN NAP1L1 25348397 N/A physical interaction ComPPI
VTN ARMCX3 25348397 N/A physical interaction ComPPI
VTN NEK1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
VTN RBM5 25348397 N/A physical interaction ComPPI
VTN POP1 25348397 N/A physical interaction ComPPI
VTN ARHGAP11A 25348397 N/A physical interaction ComPPI
VTN LEMD2 25348397 N/A physical interaction ComPPI
VTN TRMT11 25348397 N/A physical interaction ComPPI
VTN CDK4 25348397 N/A physical interaction ComPPI
VTN DCAF1 25348397 N/A physical interaction ComPPI
VTN C1QBP 24234451 25348397 27898060 8900153 association,physical association pull down,physical interaction,enzyme linked immunosorbent assay ComPPI,IntAct,OmniPath
VTN ST6GALNAC4 25348397 N/A physical interaction ComPPI
VTN CFTR 25348397 N/A physical interaction ComPPI
VTN ITGAV 1694173 24234451 25348397 physical association solid phase assay ComPPI,IntAct
VTN WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VTN GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VTN PASK 21418524 24234451 25348397 phosphorylation reaction peptide array ComPPI,IntAct
VTN NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
VTN JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
VTN GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
VTN MTA1 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
VTN UBQLN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VTN DLG3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VTN SNTG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VTN DLG2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VTN FAM20C 22582013 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
ILF2 VTN 25348397 N/A physical interaction ComPPI
SIX1 VTN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LNX2 VTN 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IK VTN 25348397 N/A physical interaction ComPPI
VTN VTN 20600001 24234451 N/A molecular sieving IntAct
PRKCA VTN 11034322 11795878 2448300 27898060 9030777 N/A N/A OmniPath
VTN ITGB1 27898060 7716514 stimulant N/A OmniPath
ATM VTN 27898060 9733784 N/A N/A OmniPath
CSNK2A1 VTN 1696913 27898060 9733784 N/A N/A OmniPath
FGG VTN 11744726 2243140 27898060 inhibition N/A OmniPath
VTN ITGAV 23154389 27898060 stimulant N/A OmniPath

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