GENE：XDH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | XDH |
| FullNmae | xanthine dehydrogenase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12805 |
| EnsembleID | ENSG00000158125 |
| Uniprot | P47989 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| XDH | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| XDH | GO:0000255,GO:0001933,GO:0001937,GO:0004854,GO:0004854,GO:0004855,GO:0005506,GO:0005515,GO:0005615,GO:0005615,GO:0005777,GO:0005829,GO:0005829,GO:0006147,GO:0006148,GO:0006149,GO:0006154,GO:0006157,GO:0006161,GO:0006196,GO:0006204,GO:0006919,GO:0007595,GO:0009114,GO:0009115,GO:0009115,GO:0010629,GO:0016226,GO:0016529,GO:0042803,GO:0043546,GO:0043605,GO:0045602,GO:0046038,GO:0046055,GO:0046059,GO:0050660,GO:0051537,GO:0051898,GO:0070674,GO:0070675,GO:0071949,GO:1900745,GO:1900747,GO:2000379,GO:2001213 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| XDH | hsa:7498 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| XDH | hsa:7498 | path:hsa00232 | Caffeine metabolism - Homo sapiens (human) |
| XDH | hsa:7498 | path:hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| XDH | hsa:7498 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| XDH | hsa:7498 | path:hsa01232 | Nucleotide metabolism - Homo sapiens (human) |
| XDH | hsa:7498 | path:hsa04146 | Peroxisome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | XDH | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | XDH | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | XDH | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | XDH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | XDH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDK5 | XDH | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | XDH | 21150319 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| XDH | BTN1A1 | 12456835 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| XDH | CCDC110 | 25348397 | N/A | physical interaction | ComPPI |
| CDK5 | XDH | 25831123 27898060 | N/A | N/A | OmniPath |