GENE：ARC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ARC |
| FullNmae | activity regulated cytoskeleton associated protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:648 |
| EnsembleID | ENSG00000198576 |
| Uniprot | Q7LC44 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ARC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ARC | GO:0001669,GO:0003729,GO:0005515,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005938,GO:0006897,GO:0007010,GO:0007010,GO:0007492,GO:0007612,GO:0007616,GO:0007616,GO:0009952,GO:0015629,GO:0016477,GO:0022604,GO:0031901,GO:0043025,GO:0043197,GO:0045121,GO:0048168,GO:0050804,GO:0051028,GO:0051260,GO:0060291,GO:0060997,GO:0061001,GO:0071598,GO:0098839,GO:0098845,GO:0098978,GO:0099149,GO:0110077,GO:1900271,GO:1900271,GO:1900452,GO:1903561,GO:2000969 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ARC | hsa:23237 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ARC | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | ARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ARC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000451A1 | ARC | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002367FA | ARC | 24763054 25416803 | mrna cleavage,inhibition | western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000004DB7E | ARC | 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F72ED | ARC | 22012620 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | ARC | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | ARC | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000195F5B | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045B99E | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000001C659 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | ARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | ARC | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D5391 | ARC | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | ARC | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| S100P | ARC | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| DLG4 | ARC | 23424281 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SUMO1 | ARC | 25348397 | N/A | physical interaction | ComPPI |
| FER | ARC | 25348397 | N/A | physical interaction | ComPPI |
| NDE1 | ARC | 25348397 | N/A | physical interaction | ComPPI |
| SUMO2 | ARC | 25348397 | N/A | physical interaction | ComPPI |
| SUMO3 | ARC | 25348397 | N/A | physical interaction | ComPPI |
| RNF216 | ARC | 25348397 | N/A | physical interaction | ComPPI |
| CSRP2 | ARC | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRT15 | ARC | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ARC | UBE3A | 25348397 | N/A | physical interaction | ComPPI |
| ARC | SH2D4A | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ARC | CORO1B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |