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GENE：VAV3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VAV3
FullNmae vav guanine nucleotide exchange factor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12659
EnsembleID ENSG00000134215
Uniprot Q9UKW4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VAV3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VAV3 GO:0001525,GO:0001772,GO:0005085,GO:0005085,GO:0005085,GO:0005096,GO:0005154,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006906,GO:0006974,GO:0007229,GO:0007264,GO:0008361,GO:0009410,GO:0016477,GO:0030032,GO:0030168,GO:0030593,GO:0030890,GO:0038095,GO:0038096,GO:0043087,GO:0043087,GO:0045785,GO:0046872,GO:0050853,GO:0051056

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VAV3 hsa:10451 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04510 Focal adhesion - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
VAV3 hsa:10451 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
VAV3 hsa:10451 path:hsa05135 Yersinia infection - Homo sapiens (human)
VAV3 hsa:10451 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
VAV3 hsa:10451 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD247 VAV3 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 26192618 7600293 8478617 8642247 9625766 9738502 interaction type N/A ACSN
ZAP70 VAV3 10562324 10925299 11353765 11438547 11875494 12415267 12731048 12811837 15735648 16713974 17371980 20435894 20814939 21059766 23414611 23508573 23620508 23886063 24378531 26192618 7600293 8478617 8642247 9625766 9738502 interaction type N/A ACSN
ITK VAV3 12186560 23109003 chemical activation reaction N/A SignaLink
LAT VAV3 12186560 23109003 chemical activation reaction N/A SignaLink
SH3BP2 VAV3 14757747 23109003 chemical activation reaction N/A SignaLink
VAV3 PRKCQ 11956228 15802604 23109003 chemical activation reaction N/A SignaLink
VAV3 PRKCB 11956228 15802604 23109003 chemical activation reaction N/A SignaLink
VAV3 PRKCD 11956228 15802604 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR VAV3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 VAV3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 VAV3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 VAV3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 VAV3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 VAV3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 VAV3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 VAV3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 VAV3 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 VAV3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000122ED0 VAV3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C770D VAV3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F VAV3 20371350 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000018E6CD VAV3 20371350 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA VAV3 20371350 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001CE046 VAV3 19536157 20371350 23592263 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001799A3 VAV3 19536157 20371350 23592263 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002367FA VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001F373E VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027F5F3 VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000045ED38 VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004929F1 VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002373FD VAV3 20371350 22012620 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004E78D3 VAV3 20371350 22012620 23592263 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A052 VAV3 21572407 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000512C88 VAV3 21572407 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E VAV3 21572407 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E VAV3 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D VAV3 21572407 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 VAV3 21572407 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 VAV3 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B7450 VAV3 20371350 23706177 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000017CCCB VAV3 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000004BACE VAV3 20371350 23706177 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000047944F VAV3 20371350 23706177 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000018D2BE VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000010BD8D VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001925C1 VAV3 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB35 VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003BD367 VAV3 20371350 23706177 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A281 VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 VAV3 20371350 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000058BB84 VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS000075D1FC VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00000BD6DC VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00002DD349 VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS0000183BED VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00001CC864 VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS0000315338 VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS0000079D48 VAV3 20371350 21572407 23446348 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS000043C1C3 VAV3 20371350 21572407 23446348 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00002F0130 VAV3 20371350 21572407 23446348 23706177 23824327 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00004C6C6F VAV3 20371350 21572407 23446348 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00002971AB VAV3 20371350 22012620 23706177 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004DEA91 VAV3 20371350 21572407 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 VAV3 20371350 21572407 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS000040780F VAV3 20371350 21572407 23706177 24906430 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00003AA845 VAV3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB VAV3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 VAV3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B VAV3 20371350 21572407 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS000048BA36 VAV3 20371350 21572407 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS0000044FD7 VAV3 20371350 21572407 23706177 24906430 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029D9F1 VAV3 20371350 21572407 23706177 24906430 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 VAV3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 VAV3 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DE669 VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000005CF5F VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000065D58 VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000170D8B VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000029EBD VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000277201 VAV3 20371350 21572407 23706177 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000365675 VAV3 21572407 22927820 23313552 23706177 23824327 24906430 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 VAV3 21572407 22927820 23313552 23706177 23824327 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00003758F0 VAV3 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00001F5B39 VAV3 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00002C7B2B VAV3 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00000EED18 VAV3 23706177 24906430 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS00004CCA62 VAV3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B VAV3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 VAV3 25416803 26972445 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC VAV3 22135298 phosphorylation N/A PhosphoSite
LCP2 VAV3 25361965 interaction type N/A PTMCode2
VAV3 LCP2 25361965 interaction type N/A PTMCode2
RAC1 VAV3 25361965 interaction type N/A PTMCode2
VAV3 RAC1 25361965 interaction type N/A PTMCode2
EGFR VAV3 25361965 interaction type N/A PTMCode2
VAV3 EGFR 25361965 interaction type N/A PTMCode2
GRB2 VAV3 25361965 interaction type N/A PTMCode2
VAV3 GRB2 25361965 interaction type N/A PTMCode2
VAV3 ALK 25361965 interaction type N/A PTMCode2
ALK VAV3 25361965 interaction type N/A PTMCode2
PIK3R1 VAV3 25361965 interaction type N/A PTMCode2
VAV3 PIK3R1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 VAV3 14525934 14757747 15708849 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TRAF6 VAV3 25348397 N/A physical interaction ComPPI
RAC1 VAV3 10523675 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RINT1 VAV3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERBB2 VAV3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
RHOG VAV3 10523675 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ZYX VAV3 14525934 25348397 8622875 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SH3BP2 VAV3 14525934 14757747 15345594 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CBLB VAV3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLNK VAV3 25348397 N/A physical interaction ComPPI
KIT VAV3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R1 VAV3 11094073 14525934 16982329 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
ROS1 VAV3 11094073 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
VAV3 GRB2 11094073 12577067 14525934 18654987 20936779 21706016 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
VAV3 SHC1 11094073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAV3 EGFR 11094073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAV3 INSR 11094073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAV3 PDGFRB 25348397 N/A physical interaction ComPPI
VAV3 ESR1 18518979 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
VAV3 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
VAV3 TNFRSF11A 25348397 N/A physical interaction ComPPI
VAV3 TRAF1 25348397 N/A physical interaction ComPPI
VAV3 TRAF3 25348397 N/A physical interaction ComPPI
VAV3 GTF2F2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
VAV3 ALK 17998938 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
VAV3 AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
VAV3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
VAV3 ZRANB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RHOA VAV3 10523675 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GAB1 VAV3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
IGF1R VAV3 11094073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VAV3 PLCG1 11094073 14525934 N/A experimental interaction detection HPRD
SRC VAV3 11917103 15708849 17998938 27898060 stimulant N/A OmniPath

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