GENE：ALPL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ALPL |
| FullNmae | alkaline phosphatase, biomineralization associated |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:438 |
| EnsembleID | ENSG00000162551 |
| Uniprot | P05186 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ALPL | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ALPL | GO:0001501,GO:0001649,GO:0001958,GO:0003006,GO:0004035,GO:0004035,GO:0004427,GO:0005509,GO:0005515,GO:0005576,GO:0005758,GO:0005886,GO:0005886,GO:0005886,GO:0016020,GO:0016311,GO:0016462,GO:0016887,GO:0019725,GO:0030282,GO:0031012,GO:0031966,GO:0032496,GO:0032868,GO:0033280,GO:0033883,GO:0034516,GO:0036005,GO:0042822,GO:0043262,GO:0046677,GO:0050187,GO:0051384,GO:0052732,GO:0055062,GO:0055074,GO:0070062,GO:0071407,GO:0071529,GO:0098552,GO:0120162,GO:0140651,GO:0140928,GO:1904383 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ALPL | hsa:249 | path:hsa00730 | Thiamine metabolism - Homo sapiens (human) |
| ALPL | hsa:249 | path:hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| ALPL | hsa:249 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ALPL | hsa:249 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAP3K14 | ALPL | 15208311 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TRAF2 | ALPL | 15208311 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TRAF3 | ALPL | 15208311 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ALPL | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | ALPL | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ALPL | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ALPL | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SP3 | ALPL | 11073119 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ALPL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TRAF3 | ALPL | 14525934 15208311 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| EEF1A1 | ALPL | 16014383 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TRAF2 | ALPL | 14525934 15208311 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| ALOX5 | ALPL | 25348397 | N/A | physical interaction | ComPPI |
| MAP3K14 | ALPL | 14525934 15208311 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,biochemical,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| SRPK2 | ALPL | 25348397 | N/A | physical interaction | ComPPI |
| EIF4A2 | ALPL | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ALPL | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| ALPL | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
| ALPL | SPCS2 | 25348397 | N/A | physical interaction | ComPPI |
| ALPL | SEC11C | 25348397 | N/A | physical interaction | ComPPI |
| L1TD1 | ALPL | 24234451 25702638 | association | anti bait coimmunoprecipitation | IntAct |
| TRAF2 | ALPL | 15208311 27898060 | N/A | N/A | OmniPath |
| MAP3K14 | ALPL | 15208311 27898060 | N/A | N/A | OmniPath |
| ALPL | BAD | 22820751 27898060 | N/A | N/A | OmniPath |
| ALPL | TRAF3 | 15208311 27898060 | N/A | N/A | OmniPath |
| TRAF3 | ALPL | 15208311 27898060 | N/A | N/A | OmniPath |
| RUNX2 | ALPL | 11331591 27898060 | stimulant | N/A | OmniPath |
| BMP2 | ALPL | 11811553 27898060 | stimulant | N/A | OmniPath |
| ALPL | H2AC11 | 27898060 6167574 | N/A | N/A | OmniPath |