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GENE：TIMP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TIMP2
FullNmae TIMP metallopeptidase inhibitor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11821
EnsembleID ENSG00000035862
Uniprot P16035

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TIMP2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TIMP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TIMP2 GO:0002020,GO:0002020,GO:0005515,GO:0005576,GO:0005615,GO:0008191,GO:0008270,GO:0009725,GO:0010951,GO:0030414,GO:0031012,GO:0034097,GO:0035580,GO:0051045,GO:0062023,GO:0140678,GO:1904724,GO:1904813,GO:1905049

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 TIMP2 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TIMP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TIMP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TIMP2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TIMP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TIMP2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TIMP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 TIMP2 8810321 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TIMP2 17332917 trascriptional regulation,stimulation inferred by curator TFlink
JUN TIMP2 8810321 trascriptional regulation,stimulation inferred by curator TFlink
NR4A1 TIMP2 22551568 trascriptional regulation,stimulation inferred by curator TFlink
PTTG1 TIMP2 19351864 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TIMP2 10764764 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TIMP2 10764764 trascriptional regulation,stimulation inferred by curator TFlink
SP3 TIMP2 10764764 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TIMP2 8810321 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000037D7E5 TIMP2 22262409 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000298BA3 TIMP2 22262409 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000298BA3 TIMP2 22262409 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000037D7E5 TIMP2 22262409 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 TIMP2 22685266 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000039E1E1 TIMP2 24440352 24444603 24704830 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000055BBE5 TIMP2 24866238 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000042E1F TIMP2 24704830 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001C11BC TIMP2 25416803 26464662 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TIMP2 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP2 25361965 interaction type N/A PTMCode2
TIMP2 MMP9 25361965 interaction type N/A PTMCode2
MMP9 TIMP2 25361965 interaction type N/A PTMCode2
MMP2 TIMP2 25361965 interaction type N/A PTMCode2
TIMP2 MMP2 25361965 interaction type N/A PTMCode2
MMP8 TIMP2 25361965 interaction type N/A PTMCode2
TIMP2 MMP8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 TIMP2 25348397 N/A physical interaction ComPPI
RAB3A TIMP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MMP3 TIMP2 25348397 N/A surface plasmon resonance ComPPI
MMP14 TIMP2 12475252 14525934 19010413 24112707 24234451 25348397 27898060 9422789 9724659 physical association anti bait coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
ITGA3 TIMP2 25348397 N/A in vivo ComPPI
ITGB1 TIMP2 25348397 N/A in vivo ComPPI
PSMA6 TIMP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HNRNPL TIMP2 25348397 N/A physical interaction ComPPI
MMP15 TIMP2 25348397 N/A protease assay ComPPI
MMP16 TIMP2 25348397 N/A protease assay ComPPI
FECH TIMP2 25348397 N/A physical interaction ComPPI
RANBP1 TIMP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBQLN2 TIMP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TIMP3 TIMP2 25348397 N/A physical interaction ComPPI
TIMP2 MMP8 10353844 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TIMP2 MMP2 10991943 12032297 12374789 14525934 24234451 25348397 9933646 N/A two hybrid,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
TIMP2 MMP1 25348397 N/A surface plasmon resonance ComPPI
TIMP2 MMP9 25348397 N/A protease assay ComPPI
TIMP2 SNCG 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMP2 PSMA7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMP2 ZMYM6 25348397 N/A physical interaction ComPPI
TIMP2 TRIM25 25348397 N/A physical interaction ComPPI
TIMP2 PGRMC1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 PSAT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 NUDC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 NPEPPS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 APC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 PSME3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 PCMT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 HSPA4L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 GANAB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 PAICS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 RPL29 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GNRHR TIMP2 17201186 27898060 stimulant N/A OmniPath

Visualization










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